O-phospho-l-serine: a modulator of bone healing in calcium-phosphate cements
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Ronald Mai
Abstract
Bone substitution materials are seen as an alternative to autogenous bone transplants in the reconstruction of human bone structures. The aim of the present animal study was to evaluate the clinical handling and the conditions of bone healing after the application of a phosphoserine and collagen-I-modified calcium-phosphate cement (Biozement D). The application of phosphoserine is supposed to influence the texture of the extracellular matrix. Standardised bone defects were created in the lower jaw of 10 adult minipigs. These defects were reconstructed with a pasty calcium-phosphate cement mixture. After a healing time of 4 months, the animals were sacrificed. The mandibles of all animals were resected and non-decalcified histological sections of the areas of interest were prepared. The experiment was evaluated by means of qualitative histology and histomorphometry. The hydroxyapatite cement entirely hardened intraoperatively. Modelling and handling of the cement was facile and the margin fit to the host bone was excellent. Histology showed that resorption started in the periphery and proceeded exceptionally fast. The bony substitution, especially in phosphoserine-endowed cements, was very promising. After a healing period of 4 months, phosphoserine cements showed a bone regeneration of nearly two-thirds of the defect sizes. In the applied animal experiment, the newly developed hydroxyapatite collagen-I cement is well suited for bone substitution due to its easy handling, its excellent integration and good resorption characteristics. The addition of phosphoserine is very promising in terms of influencing resorption features and bone regeneration.
©2008 by Walter de Gruyter Berlin New York
Articles in the same Issue
- Guest editorial
- Biomechanics and biomaterials in oral rehabilitation and dental treatment
- Mini review
- Bone quality, quantity and metabolism in terms of dental implantation
- Research articles
- Finite element representation of bone substitute remodelling in the jaw bone
- The biomaterial influences the ossification after sinus floor elevation using tissue-engineered bone grafts
- O-phospho-l-serine: a modulator of bone healing in calcium-phosphate cements
- A new design for post and core restorations implementing positive locking
- Mechanical loading of orthodontic miniscrews – significance and problems: an experimental study
- Effect of load angulation and crown shape on forces acting on post and core restored teeth: an in vitro study
- Failure analysis of a new post-and-core restoration system using the finite element method
- The influence of the root cross-section on the stress distribution in teeth restored with a positive-locking post and core design: a finite element study
- Reproducibility of electronic tooth colour measurements
Articles in the same Issue
- Guest editorial
- Biomechanics and biomaterials in oral rehabilitation and dental treatment
- Mini review
- Bone quality, quantity and metabolism in terms of dental implantation
- Research articles
- Finite element representation of bone substitute remodelling in the jaw bone
- The biomaterial influences the ossification after sinus floor elevation using tissue-engineered bone grafts
- O-phospho-l-serine: a modulator of bone healing in calcium-phosphate cements
- A new design for post and core restorations implementing positive locking
- Mechanical loading of orthodontic miniscrews – significance and problems: an experimental study
- Effect of load angulation and crown shape on forces acting on post and core restored teeth: an in vitro study
- Failure analysis of a new post-and-core restoration system using the finite element method
- The influence of the root cross-section on the stress distribution in teeth restored with a positive-locking post and core design: a finite element study
- Reproducibility of electronic tooth colour measurements
