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Autonomic cardiac control in animal models of cardiovascular diseases. I. Methods of variability analysis

  • Niels Wessel , Robert Bauernschmitt , Dirk Wernicke , Jürgen Kurths and Hagen Malberg
Published/Copyright: February 22, 2007
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Biomedical Engineering / Biomedizinische Technik
From the journal Volume 52 Issue 1

Abstract

Analysis of heart rate variability (HRV) and blood pressure variability (BPV) and baroreceptor sensitivity (BRS) has become a proven tool in clinical cardiovascular diagnostics and risk stratification. In the present work, traditional and new methodological approaches for analysis of HRV, BPV, and BRS data are summarized. HRV, BPV, and BRS parameters were obtained from animal studies designed to study pathogenetic mechanisms of distinct cardiovascular diseases. Different non-linear approaches for HRV and BPV analysis are presented here, in particular measures of complexity based on symbolic dynamics. The dual sequence method (DSM) was employed for BRS analysis. In comparison to the classical measure of BRS using the average slope [ms/mm Hg], DSM offers additional information about the time-variant coupling between BPV and HRV. Since cardiovascular regulation shares common features among different species, data on HRV and BPV, as well as BRS, in animal models might be useful for understanding the pathogenetic mechanisms of cardiovascular diseases in humans and in the development of new diagnostic approaches.


Corresponding author: Niels Wessel, University of Potsdam, Am Neuen Palais 10, 144415 Potsdam, Germany Phone: +49-331-9771639 or +49-30-94172450 Fax: +49-331-9771142

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Published Online: 2007-02-22
Published in Print: 2007-02-01

©2007 by Walter de Gruyter Berlin New York

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