Asef is a Cdc42-specific guanine nucleotide exchange factor

References

Bellanger, J.M., Astier, C., Sardet, C., Ohta, Y., Stossel, T.P., and Debant, A. (2000). The Rac1-and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin. Nat. Cell Biol.2, 888–892.10.1038/35046533Suche in Google Scholar

Cherfils, J. and Chardin, P. (1999). GEFs: structural basis for their activation of small GTP-binding proteins. Trends Biochem. Sci.24, 306–311.10.1016/S0968-0004(99)01429-2Suche in Google Scholar

Derewenda, U., Oleksy, A., Stevenson, A.S., Korczynska, J., Dauter, Z., Somlyo, A.P., Otlewski, J., Somlyo, A.V., and Derewenda, Z.S. (2004). The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca²⁺ sensitization pathway in smooth muscle. Structure12, 1955–1965.10.1016/j.str.2004.09.003Suche in Google Scholar

Dvorsky, R. and Ahmadian, M.R. (2004). Always look on the bright site of Rho: structural implications for a conserved intermolecular interface. EMBO Rep.5, 1130–1136.10.1038/sj.embor.7400293Suche in Google Scholar

Erickson, J.W. and Cerione, R.A. (2004). Structural elements, mechanism, and evolutionary convergence of Rho protein-guanine nucleotide exchange factor complexes. Biochemistry43, 837–842.10.1021/bi036026vSuche in Google Scholar

Etienne-Manneville, S. and Hall, A. (2002). Rho GTPases in cell biology. Nature420, 629–635.10.1038/nature01148Suche in Google Scholar

Fiegen, D., Haeusler, L.C., Blumenstein, L., Herbrand, U., Dvorsky, R., Vetter, I.R., and Ahmadian, M.R. (2004). Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase. J. Biol. Chem.279, 4743–4749.10.1074/jbc.M310281200Suche in Google Scholar

Fukuhara, S., Murga, C., Zohar, M., Igishi, T., and Gutkind, J.S. (1999). A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. J. Biol. Chem.274, 5868–5879.10.1074/jbc.274.9.5868Suche in Google Scholar

Fukuhara, S., Chikumi, H., and Gutkind, J.S. (2000). Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G₁₂ family to Rho. FEBS Lett.485, 183–188.10.1016/S0014-5793(00)02224-9Suche in Google Scholar

Guo, Z., Ahmadian, M.R., and Goody, R.S. (2005). Guanine nucleotide exchange factors operate by a simple allosteric competitive mechanism. Biochemistry44, 15423–15429.10.1021/bi0518601Suche in Google Scholar PubMed

Haeusler, L.C., Blumenstein, L., Stege, P., Dvorsky, R., and Ahmadian, M.R. (2003). Comparative functional analysis of the Rac GTPases. FEBS Lett.555, 556–560.10.1016/S0014-5793(03)01351-6Suche in Google Scholar

Hart, M.J., Sharma, S., el Masry, N., Qiu, R.G., McCabe, P., Polakis, P., and Bollag, G. (1996). Identification of a novel guanine nucleotide exchange factor for the Rho GTPase. J. Biol. Chem.271, 25452–25458.10.1074/jbc.271.41.25452Suche in Google Scholar

Hemsath, L. and Ahmadian, M.R. (2005). Fluorescence approaches for monitoring interactions of RhoGTPases with nucleotides, regulators and effectors. Methods37, 173–182.Suche in Google Scholar

Hoffman, G.R. and Cerione, R.A. (2002). Signaling to the Rho GTPases: networking with the DH domain. FEBS Lett.513, 85–91.10.1016/S0014-5793(01)03310-5Suche in Google Scholar

Karnoub, A.E., Worthylake, D.K., Rossman, K.L., Pruitt, W.M., Campbell, S.L., Sondek, J., and Der, C.J. (2001). Molecular basis for Rac1 recognition by guanine nucleotide exchange factors. Nat. Struct. Biol.8, 1037–1041.10.1038/nsb719Suche in Google Scholar PubMed

Karnoub, A.E., Symons, M., Campbell, S.L., and Der, C.J. (2004). Molecular basis for Rho GTPase signaling specificity. Breast Cancer Res. Treat.84, 61–71.10.1023/B:BREA.0000018427.84929.5cSuche in Google Scholar

Kawasaki, Y., Senda, T., Ishidate, T., Koyama, R., Morishita, T., Iwayama, Y., Higuchi, O., and Akiyama, T. (2000). Asef, a link between the tumor suppressor APC and G-protein signaling. Science289, 1194–1197.10.1126/science.289.5482.1194Suche in Google Scholar PubMed

Kawasaki, Y., Sato, R., and Akiyama, T. (2003). Mutated APC and Asef are involved in the migration of colorectal tumour cells. Nat. Cell Biol.5, 211–215.10.1038/ncb937Suche in Google Scholar PubMed

Kozasa, T., Jiang, X., Hart, M.J., Sternweis, P.M., Singer, W.D., Gilman, A.G., Bollag, G., and Sternweis, P.C. (1998). p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13. Science280, 2109–2111.10.1126/science.280.5372.2109Suche in Google Scholar PubMed

Kristelly, R., Gao, G., and Tesmer, J.J.G. (2004). Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. J. Biol. Chem.279, 47352–47362.10.1074/jbc.M406056200Suche in Google Scholar PubMed

Movilla, N. and Bustelo, X.R. (1999). Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. Mol. Cell. Biol.19, 7870–7885.10.1128/MCB.19.11.7870Suche in Google Scholar PubMed PubMed Central

Noritake, J., Watanabe, T., Sato, K., Wang, S., and Kaibuchi, K. (2005). IQGAP1: A key regulator of adhesion and migration. J. Cell Sci.118, 2085–2092.10.1242/jcs.02379Suche in Google Scholar PubMed

Raftopoulou, M. and Hall, A. (2004). Cell migration: Rho GTPases lead the way. Dev. Biol.265, 23–32.10.1016/j.ydbio.2003.06.003Suche in Google Scholar PubMed

Reid, T., Bathoorn, A., Ahmadian, M.R., and Collard, J.G. (1999). Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42. J. Biol. Chem.274, 33587–33593.10.1074/jbc.274.47.33587Suche in Google Scholar PubMed

Rossman, K.L. and Sondek, J. (2005). Larger than DbI: new structural insights into RhoA activation. Trends Biochem. Sci.30, 163–165.10.1016/j.tibs.2005.02.002Suche in Google Scholar PubMed

Rossman, K.L., Worthylake, D.K., Snyder, J.T., Cheng, L., Whitehead, I.P., and Sondek, J. (2002a). Functional analysis of Cdc42 residues required for guanine nucleotide exchange. J. Biol. Chem.277, 50893–50898.10.1074/jbc.M208580200Suche in Google Scholar PubMed

Rossman, K.L., Worthylake, D.K., Snyder, J.T., Siderovski, D.P., Campbell, S.L., and Sondek, J. (2002b). A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. EMBO J.21, 1315–1326.10.1093/emboj/21.6.1315Suche in Google Scholar PubMed PubMed Central

Rossman, K.L., Cheng, L., Mahon, G.M., Rojas, R.J., Snyder, J.T., Whitehead, I.P., and Sondek, J. (2003). Multifunctional roles for the PH domain of Dbs in regulating rho GTPase activation. J. Biol. Chem.278, 18393–18400.10.1074/jbc.M300127200Suche in Google Scholar PubMed

Rossman, K.L., Der, C.J., and Sondek, J. (2005). GEF means go: Turning on Rho GTPases with guanine nucleotide-exchange factors. Nat. Rev. Mol. Cell Biol.6, 167–180.10.1038/nrm1587Suche in Google Scholar PubMed

Schiller, M.R. (2006). Coupling receptor tyrosine kinases to Rho GTPases–GEFs what's the link. Cell. Signal.18, 1834–1843.10.1016/j.cellsig.2006.01.022Suche in Google Scholar PubMed

Schmidt, A. and Hall, A. (2002). Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev.16, 1587–1609.10.1101/gad.1003302Suche in Google Scholar PubMed

Snyder, J.T., Worthylake, D.K., Rossman, K.L., Betts, L., Pruitt, W.M., Siderovski, D.P., Der, C.J., and Sondek, J. (2002). Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat. Struct. Biol.9, 468–475.10.1038/nsb796Suche in Google Scholar

Stam, J.C. and Collard, J.G. (1999). The DH protein family, exchange factors for Rho-like GTPases. Prog. Mol. Subcell. Biol.22, 51–83.10.1007/978-3-642-58591-3_4Suche in Google Scholar

van Horck, F.P.G., Ahmadian, M.R., Haeusler, L.C., Moolenaar, W.H., and Kranenburg, O. (2001). Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules. J. Biol. Chem.276, 4948–4956.10.1074/jbc.M003839200Suche in Google Scholar

Vetter, I.R. and Wittinghofer, A. (2001). Signal transduction-the guanine nucleotide-binding switch in three dimensions. Science294, 1299–1304.10.1126/science.1062023Suche in Google Scholar

Whitehead, I.P., Campbell, S., Rossman, K.L., and Der, C.J. (1997). Dbl family proteins. Biochim. Biophys. Acta1332, F1–F23.10.1016/S0304-419X(96)00040-6Suche in Google Scholar

Whitehead, L.P., Lambert, Q.T., Glaven, J.A., Abe, K., Rossman, K.L., Mahon, G.M., Trzaskos, J.M., Kay, R., Campbell, S.L., and Der, C.J. (1999). Dependence of Dbl and Dbs transformation on MEK and NF-κB activation. Mol. Cell. Biol.19, 7759–7770.10.1128/MCB.19.11.7759Suche in Google Scholar

Zheng, Y. (2001). Dbl family guanine nucleotide exchange factors. Trends Biochem. Sci.26, 724–732.10.1016/S0968-0004(01)01973-9Suche in Google Scholar