Self-organization versus Watchmaker: stochastic dynamics of cellular organization
Abstract
The cell, as a molecular system, is often interpreted in terms of complex clockworks, and the design charts of mechanical and electrical engineering are assumed to provide adequate approximations for the description of cellular organization. However, a growing body of experimental evidence obtained through the observation and analysis of real-time dynamics of fluorescently labeled molecules inside living cells is increasingly inconsistent with the classico-mechanistic perception of the cell. An overview of recent studies favors an emerging alternative image of the cell as a dynamic integrated system of interconnected and interdependent metastable molecular organizations realized through stochasticity and self-organization.
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Articles in the same Issue
- Signaling in Biochemical Pharmacology and Toxicology
- Oncogenic Ras in tumour progression and metastasis
- Phosphoinositide 3-kinase signaling in the cellular response to oxidative stress
- Doxorubicin induces EGF receptor-dependent downregulation of gap junctional intercellular communication in rat liver epithelial cells
- TGFβ-induced focal complex formation in epithelial cells is mediated by activated ERK and JNK MAP kinases and is independent of Smad4
- On the mechanism of alkylphosphocholine (APC)-induced apoptosis in tumour cells
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- Varicella-zoster virus IE63 protein represses the basal transcription machinery by disorganizing the pre-initiation complex
- Trehalose and 6-aminohexanoic acid stabilize and renature glucose-6-phosphate dehydrogenase inactivated by glycation and by guanidinium hydrochloride
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- Enzymatic profiling of human kallikrein 14 using phage-display substrate technology
- A new selective substrate for cathepsin E based on the cleavage site sequence of α2-macroglobulin