Singlet Molecular Oxygen Triggers the soxRS Regulon of Escherichia coli
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Lucymara F. Agnez-Lima
Abstract
The electronically excited molecular oxygen (singlet oxygen, [1]O[2]) can be detrimental to cells in several ways, although recent reports indicate that it may play a role as an intercellular signal in eukaryotes. Here we present evidence that [1]O[2], generated by thermodissociation of disodium 3,3(1,4-naphthylidene) diproprionate endoperoxide, activates transcription of genes of the soxRS regulon, and that this induction is paralleled by induction of a soxS::lacZ operon fusion. The inductions were dependent on a functional soxR gene. These data imply that protective responses, such as induction of the soxRS regulon, may be triggered by diverse environmental oxidative stresses, and that [1]O[2] may also function as a signal molecule in prokaryotes.
Copyright © 2001 by Walter de Gruyter GmbH & Co. KG
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- Functional Genomics in HIV-1 Virus Replication: Protein-Protein Interactions as a Basis for Recruiting the Host Cell Machinery for Viral Propagation
- On the Characterization of the Putative S20-Thx Operon of Thermus thermophilus
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