Chapters in this book

1. Frontmatter 1
2. Table of contents 5
3. Preface 7
4. 1 The lock-and-key analogy and its influence on 20^th century biochemistry 9
5. 2 The lock-and-key analogy in Emil Fischer’s program on sugar fermentation, 1890-1907 39
6. 3 The making of the lock-and-key model of the antibody-antigen relationship, 1886-1930 77
7. 4 Lock-and-key foundations for molecular biology: Linus Pauling and the Caltech group, 1930-1960 133
8. 5 Lock-and-key-based modeling and its influence on the development of biochemical research programs 173
9. 6 Concluding remarks on the construction of analogy-based research programs 199
10. Literature 205