Single and Double Strand Breaks in the Cellular DNA

Kapitel in diesem Buch

1. Frontmatter 1
2. Contents 5
3. Introduction 7
4. Fundamentals of DNA repair
5. Single and Double Strand Breaks in the Cellular DNA 15
6. Some Aspects of Unscheduled DNA synthesis in Irradiated Cells 27
7. Comparative Evaluation of the DNA Repair Contribution to the Recovery of the Viability of Bacteria and the Eukaryotic Cells after Irradiation 33
8. The Biological Specificity of DNA Synthesis 53
9. DNA repair after U V-irradiation and alkylating agents
10. Rejoining of Incision Breaks in the DNA of Ultraviolet- Irradiated Proteus Mirabilis Wildtype and UV-sensitive Mutants 67
11. UV-light Sensitivity and Split-dose Effects in two Strains of Murine Leukaemic L5178Y Cells 73
12. DNA Repair in Barley after the Action of Methyl Nitrosourea and Sulphonic Acid Esters 85
13. Modification of DNA repair by exogenous factors
14. Studies on Alterations of DNA Repair Processes 95
15. Photodynamically Induced DNA Damage, their Repair and the Influence of Different Chemicals on the Repair Process 111
16. An Influence of Freezing the Cells on the Formation of Single-Strand Breaks in DNA after Irradiation 117
17. Diseases associated with defective DNA repair
18. Xeroderma Pigmentosum — Report of Three Cases and Ultrastructural Investigation of Sun-unexposed Tumour-free Skin 125
19. Effects of UV-Light on DNA Synthesis in Photodermatoses 151
20. Defective Repair of y-Irradiated DNA in a Case of Xeroderma Pigmentosum 157
21. Clinical aspects of DNA repair
22. The Importance of Frame-Shift Mutations in Carcinogenesis 175
23. Clinical Aspects of DNA Repair 181
24. List of Authors 197
25. Index 199