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Machine learning approaches to improve electrospun nanofibers’ performance and properties for medical applications

  • D.M. Gokul Varshan , Savita Verma ORCID logo , Swati Mutha , P. Balaji and M. Anand
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Abstract

Nanofibers, known as electrospun, have brightened various sections of biomedical applications, especially the areas of drug delivery and tissue regenerationtissue regeneration. This chapter also analyzed advanced applications and progress in electrospun nanofibers; this elucidates the additive impact the nanofibers make to the characteristics and performance improvements through various techniques. Advances in electrospinning, such as coaxial and multineedle systems, have made it possible to produce nanofibers with customized properties for particular medicinal uses. Their applicability has been further increased by functionalization techniques such as chemical, physical, and biological alterations, which have made it easier to create nanofibers with improved bioactivity and performance. Key applications that are being addressed are tissue engineering, where nanofiber scaffolds assist stem cell differentiation and tissue regeneration, and targeted drug delivery systems for cancer therapy, where nanofibers offer controlled release and lower systemic toxicity. The application of biodegradable nanofibers in wound healing is also covered in this chapter, with an emphasis on how to reduce scarring and encourage recovery without scars. Future directions to improve the functionality and design of nanofibernanofibers include the incorporation of machine learning techniques. This thorough analysis highlights the potential of electrospun nanofibers to transform healthcare by offering insightful information on their present and possible future uses in medicine.

Abstract

Nanofibers, known as electrospun, have brightened various sections of biomedical applications, especially the areas of drug delivery and tissue regenerationtissue regeneration. This chapter also analyzed advanced applications and progress in electrospun nanofibers; this elucidates the additive impact the nanofibers make to the characteristics and performance improvements through various techniques. Advances in electrospinning, such as coaxial and multineedle systems, have made it possible to produce nanofibers with customized properties for particular medicinal uses. Their applicability has been further increased by functionalization techniques such as chemical, physical, and biological alterations, which have made it easier to create nanofibers with improved bioactivity and performance. Key applications that are being addressed are tissue engineering, where nanofiber scaffolds assist stem cell differentiation and tissue regeneration, and targeted drug delivery systems for cancer therapy, where nanofibers offer controlled release and lower systemic toxicity. The application of biodegradable nanofibers in wound healing is also covered in this chapter, with an emphasis on how to reduce scarring and encourage recovery without scars. Future directions to improve the functionality and design of nanofibernanofibers include the incorporation of machine learning techniques. This thorough analysis highlights the potential of electrospun nanofibers to transform healthcare by offering insightful information on their present and possible future uses in medicine.

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