A Contribution to the Pathologic Anatomy of the Cerebral Microcirculation

Chapters in this book

1. Frontmatter 1
2. Introduction 5
3. Contents 9
4. I. Development and Structure of Microvasculature of the CNS
5. Ontogenesis of the Terminal Vascular Bed in CNS 15
6. Damaging of the Cerebral Vessels or Disturbances in their Development as seen in Rat and Mouse Embryos under the Influence of Teratogenic Substances 20
7. The Vascular Pattern in Areas of Rhombencephalon Equipped with Narrow or Wide Meshed Capillary Network 24
8. Anastomoses in the Vascular Bed of the Human Cerebrum 26
9. Fine Structure of the Cerebral Arteries with Special Reference to their Functional Role 39
10. Comparative Studies on Spinal Cord Microvasculature 45
11. Pericapillary Spaces in the Human Spinal Cord 59
12. X-Ray Microscopy: a New Neurological Approach 67
13. II. Hemodynamics and Regulation of Cerebral Circulation
14. Ion Transport across the Choroidal Epithelium 85
15. Ionic Concentrations and Membrane Potential in Cerebral and Extracerebral Arteries 96
16. The Influence of Electrical Stimulation and Vasoactive Substances on H+-Activity of the Surfaces of Pial Vessels 121
17. Effects of Indomethacine and D 600 on the Smooth Muscles of Pial Vessels 130
18. Cortical Surface Arterial Microvascular Pressures in the Anesthetized Primate during CO₂ Inhalation 137
19. Simulation of Flow and Pressure Distributions in the Circle of Willis 140
20. The Lack of Precise Regulation of Blood Flow in Cerebral White Matter 153
21. Microcirculation Measured under Normal Conditions and with Experimentally Changed Parameters in the Gray Matter of Anesthetized Cats 159
22. Hypertension and Regional Cerebral Blood Flow 164
23. The Neural Control of Cerebral Blood Vessels - a Brief Review and a New Hypothesis 174
24. Amine Mechanisms in Brain Vessels, with Particular Regard to Autonomic Innervation and Blood-Brain Barrier 184
25. III. Pathology of Cerebral Microvasculature
26. Fine Structural Alterations of Small Vessels in the Nervous System 203
27. Transport of Protein Tracers across Cerebral Arterioles under Normal Conditions 218
28. The Permeability of Cerebral Capillaries to a Tracer Molecule, Alcian Blue, with a Molecular Weight of 1390 228
29. The Significance of Pericapillary Astroglia for Cerebral Cortical Blood Flow and EEG Activity 235
30. Pathophysiology of Cerebral Blood Flow Dynamics in Cardiac Arrest 244
31. A Model of Focal Brain Ischemia Obtained by Intracarotid ADP Infusion in Rabbits 251
32. Microcirculatory Disturbances in the Canine Spinal Cord Produced by Contrast Media in Aortography 256
33. Scanning find Transmission Electron Microscopic Study of Endothelial Lesions Following Ischemia with Special Attention to Ischemic and "Normal" Branch Points 267
34. Lesions of Microvasculature in Brain Edema 274
35. Changes in Perineuronal Capillaries Accompanying Chromatolysis of Motoneurons 282
36. Microvascular Pathology of the Brain in Cats Following Transient Increases in Intracranial Pressure 289
37. Peripheral Heart in Brain 294
38. IV. Anoxia, Ischemia and Related Conditions
39. Neuropathology of Total Oxygen Lack (Anoxia) in Rhesus Monkey 299
40. Electron Microscopic Study of Ischemic and Histotoxic Cerebral Hypoxia. Correlation of Ultrastructural Changes and Cerebral Blood Flow 307
41. Patterns of Ischemia after Acute Middle Cerebral Occlusion in the Monkey 315
42. Cerebral Protein Synthesis and Polysome Profiles after Prolonged Periods of Complete Ischemia 327
43. Intraluminal, Regulatory and Permeability Changes in the Cerebral Vasculature Caused by Ischemia 333
44. Observations on Experimental Cerebral Ischemia in Mongolian Gerbils 338
45. Changes in Intracranial Blood Flow Distribution Following Circumscribed Hemispheric Lesions as Studied by the "Single Dye Passage" Technique 342
46. Factors Influencing the Recovery of the Monkey Brain after Prolonged Cerebral Ischemia 354
47. The Effect of Ischemia on the Brain Uptake of ¹⁴C Glucose Analogues and ¹⁴C/Sucrose 361
48. Study on the Mechanism and Kinetics of Brain Edema Induced by Ischemia and Hypoxia 367
49. Morphometric Analysis of Capillaries in the Cortex of the Cat under Hypovolemic Conditions 372
50. The Influence of 5-Hydroxytryptamine on Brain Edema and Microcirculation 380
51. The Effect of Hypovolemic Oligemia on the Cerebral Microcirculation and EEG in the Cat (Wigger's Model) 386
52. V. Human Pathology and Clinical Approach
53. Ischemic Brain Damage in Arterial Boundary Zones in Man 397
54. Histological Correlates of Microvascular Pattern within the Ischemic Lesions of the Brain in Circulatory Arrest 405
55. Experimental and Clinical Studies of Cerebral Blood Flow after Carotid Ligation 414
56. Comparative Study of Neuropathological Findings and Coagulation Parameters in Disseminated Intravascular Coagulation 419
57. Refining the Indication for Microvascular Brain Surgery by Measurement of Regional Cerebral Blood Flow 425
58. The Studies of Cerebral Arterioles and Capillaries in Normal and Pathologic States in Man 431
59. A Contribution to the Pathologic Anatomy of the Cerebral Microcirculation 442
60. Intercapillary Bridges and the Development of Brain Capillaries 448
61. Alterations of Microvasculature in Progressive Subcortical Encephalopathy (Binswanger) 454
62. Injuries of Blood Vessels of the Cerebral Surface and their Consequences 462
63. Ultrastructure of Small Blood Vessels in Brain Tuberculomas 469
64. Effect of Chronic Compression on the Microcirculation and Function of Peripheral Nerves 483
65. Modifications of Vascular Reticulin Network in Multiple Sclerosis Plaques 492
66. List of Contributors 499
67. Subject Index 513