World Medical Association Declaration of Helsinki

Kapitel in diesem Buch

1. Frontmatter I
2. Editors V
3. List of first-mentioned contributors V
4. Preface IX
5. Contents XI
6. Research methods and the discovery of insulin 1
7. The discovery of the oral treatment of diabetes mellitus with sulphonylureas 11
8. Epidemiological research methodologies for the study of the aetiology of IDDM 21
9. Epidemiological research methodologies for NIDDM 37
10. Methodological concerns in diagnosing the prediabetic state 57
11. Genetic patterns of IDDM related to environmental factors 73
12. Immune mechanisms of beta cell destruction in the prediabetic phase of IDDM patients: research methodologies identifying susceptible individuals 89
13. Interventions attempting at preventing or ameliorating the development of type 1 diabetes 105
14. Assays for measuring proinsulin, insulin, and related peptides 119
15. Assessment of insulin production and secretion dynamics in health and disease, including diabetes 133
16. Methodologies in characterization and classification of prediabetic states to non-insulin-dependent diabetes mellitus (NIDDM) 147
17. Research methodologies in hypoglycaemia: counterregulation phenomena and nerve/brain dysfunction 171
18. Methods in evaluating lipoprotein and triglyceride metabolism in diabetes 191
19. Research methodologies in the evaluation of intestinal glucose absorption and the concept of glycaemic index 205
20. Evaluation of cardiac autonomic neuropathy by heart rate variability 219
21. Methodologies in sodium-lithium countertransport as related to other cation transport systems in diabetes 241
22. Methods in the assessment of transcapillary escape rate of plasma proteins 255
23. Measurement of advanced glycosylation endproducts 273
24. Research methodologies in the evaluation of home glucose monitoring 287
25. Measurements of glycated haemoglobin and other circulating glycated proteins 299
26. Research methodologies in evaluating patient education in diabetes — to reflect on the goals of patient education 319
27. Research methodologies in diabetic retinopathy 333
28. Methodologies to assess renal function in diabetes mellitus 359
29. Conducting clinical trials in diabetic eye disease 387
30. Economic analysis in diabetes 405
31. Research methodologies in connective tissue changes and diabetic skin disease 417
32. Measurement of extracellular fixed anionically charged molecules 433
33. Methods in measuring glucose transporters and insulin receptors in target cells from humans 449
34. World Medical Association Declaration of Helsinki 463
35. Subject index 467