Impaired conversion of thyroxine to triiodothyronine causing elevated concentrations of thyroxine and TSH in an euthyroid patient

Kapitel in diesem Buch

1. Frontmatter I
2. Preface V
3. Contents VII
4. I. Regulation of TSH-secretion
5. Biosynthesis of Thyrotropin releasing hormone 3
6. Hormonal regulation of Thyrotropin gene expression 7
7. Regulation of Thyrotropin secretion and its derangements 15
8. TSH-Release and TSH-synthesis: two different effects of TRH 49
9. Feedback regulation and thyroid status evaluated by an ultrasensitive TSH-IRMA in euthyroidism and borderline hyperthyroidism 55
10. The effect of Metoclopramide on the TSH and PRL response to TRH in patients treated for depression 61
11. Secondary hyperthyroidism associated with pituitary chromophobe adenoma: Study of TSH chemistry and release 71
12. Hyperthyroidism and thyroid hormone resistance 77
13. Comparison of TSH secretory response and plasma TRH levels after intravenous and nasal TRH administration 89
14. Thyrotropin serum concentration as a function of peripheral concentrations of thyroxine, triiodothyronine, reverse triiodothyronine, and thyroliberin 97
15. II. Sensitive methods for the measurements of TSH
16. Sensitive immunoassays for the determination of thyrotropin levels in serum 105
17. Studies on different hypersensitive TSH tests 121
18. Clinical comparison of 5 kits for sensitive TSH determination in hyperthyroidism and in non thyroidal illness 139
19. Comparison by receiver operating characteristics (ROC) analysis of three thyrotropin assays in the diagnosis of hyperthyroidism 145
20. Comparative evaluation of high sensitivity TSH kits 151
21. Trends in performance of clinical TSH assays as assessed by the United Kingdom EQAS for thyroid related hormones 165
22. III. TSH in non-thyroidal illness
23. Thyroidal and extrathyroidal influences on TSH before and after TRH stimulation 173
24. Parameters of thyroid function in patients on hemodialysis 185
25. TSH-Immunoradiometric assay (IRMA) in geriatric patients 189
26. Low T₃ syndrome and pituitary thyrotrophin function in diabetes mellitus in relation to type of diabetes and metabolic control — a review 193
27. TRH test and diagnostic of undefined secondary amenorrhea 199
28. Value of an immunoradiometric assay for thyrotropin in non-thyroidal illness 203
29. IV. TSH in clinical diagnostics
30. Thyrotropin — clinical relevance of sensitive TSH-assays 207
31. TSH response to TRH as a function of basal serum TSH — new aspects in pituitary-thyroid regulation 219
32. Clinical value of blunted TSH-response 227
33. Sensitive TSH test in clinical routine: possibility of prediction of response to TRH from baseline TSH concentrations 239
34. TSH measured with sensitive RIA method in euthyroid goiter patients 245
35. Application of a sensitive immunoradiometric assay (IRMA) for TSH in the diagnosis and follow-up thyroid disorders 251
36. Significance of TRH test in strumectomized patients for life-long thyroid hormone treatment 259
37. Diagnostic significance of basal TSH-concentrations (TSH-IRMA) 265
38. Impaired conversion of thyroxine to triiodothyronine causing elevated concentrations of thyroxine and TSH in an euthyroid patient 271
39. TSH-levels after operation of autonomously functioning thyroid tissue-enucleation versus resection of solitary nodules 277
40. Serum TSH determination by IRMA-mat-TSH assay in patients with functioning thyroid nodules 285
41. High sensitivity TSH in assessing thyroid function of patients 289
42. V. The thyroid TSH receptor and TSH receptor antibodies
43. V The thyroid TSH receptor and TSH receptor antibodies 297
44. TSH-receptor antibodies 307
45. TSH-binding analysis and TSH-receptor distribution pattern in thyroid disease 315
46. Clinical significance of antibodies to the TSH-receptor (stimulating and blocking thyroid function) 323
47. Autoantibodies reacting with thyroid plasma membranes in Graves' disease: importance of multiple plasma membrane antigens 337
48. Thyroid growth stimulating immunoglobulins: Clinical significance in euthyroid goitre and relationship to thyrotropin-binding inhibiting antibodies 345
49. Detection of antibodies directed against bovine TSH in patients with and without endocrine ophthalmopathy 355
50. List of contributors 357
51. Authors' index 359
52. Subject index 361
53. Backmatter 362