ROLE OF THE C-TERMINUS OF THE FIBRINOGEN y-CHAIN IN FIBRINOGEN Ca²⁺ BINDING AND IN FIBRIN POLYMERIZATION

Kapitel in diesem Buch

1. Frontmatter I
2. PREFACE V
3. CONTENTS VII
4. I. PHYSICOCHEMICAL ASPECTS
5. PARACRYSTALLINE STRUCTURE OF NATIVE HUMAN FIBRINOGEN 3
6. DETERMINATION OF FIBRIN STRUCTURES BY LIGHT SCATTERING 11
7. PARTICULARITIES OF FIBRINOGEN, ROD-LIKE AND BRANCHED FIBRINS 29
8. TEMPERATURE EFFECTS ON FIBRIN(OGEN)-FIBRIN SOLUTIONS (Preliminary results) 43
9. HYDRODYNAMIC CHARACTERIZATION OF PLASMIN DEGRADATION PRODUCTS PROM HUMAN FIBRINOGEN 47
10. THE KINETICS OF FIBRIN FORMATION 59
11. II. BIOCHEMICAL ASPECTS
12. STRUCTURE - FUNCTION - EVOLUTION RELATIONSHIP IN FIBRINOGEN 67
13. ARTIFACTUAL HETEROGENEITY OF HUMAN FIBRINOGEN POLYPEPTIDE CHAINS CAUSED BY CARBOXYMETHYLATION 83
14. INFLUENCE OF SIALIC ACID ON THE ADULT AND FETAL FIBRINOGEN-FIBRIN TRANSITION 91
15. FIBRIN FORMATION IN THE PRESENCE OF TRYPSIN 101
16. CHARACTERISATION OF RAT FIBRINOGEN 109
17. CHARACTERISATION OF PIG FIBRINOGEN 115
18. III. ABNORMAL FIBRINOGENS
19. ON DYSFIBRINOGENEMIA 123
20. DETECTION OF FIBRINOGEN ABNORMALITY IN DYSFIBRINOGENEMIA SPECIAL REPORT ON FIBRINOGEN METZ CHARACTERIZED BY AN AMINO ACID SUBSTITUTION LOCATED AT THE PEPTIDE BOND CLEAVED BY THROMBIN. 129
21. BINDING OF CITRATE TO NORMAL FIBRINOGEN AND TO METZ FIBRINOGEN 145
22. THE SEARCH FOR MOLECULAR DEFECTS IN ABNORMAL FIBRINOGENS 153
23. FIBRINOGEN BERN I: A HEREDITARY FIBRINOGEN VARIANT WITH DEFECTIVE CONFORMATIONAL STABILIZATION BY CALCIUM IONS 167
24. CARBOHYDRATE IN ABNORMAL FIBRINOGENS 183
25. OBSERVATION ON A NEW VARIANT OF HEREDITARY DYSFIBRINOGENEMIA (HDMBURG I) WITH DELAYED FIBRIN POLYMERIZATION AND WITHOUT CLINICAL ABNORMALITY 193
26. IV. FIBRINOPEPTIDE DETERMINATION
27. FPA-RELEASE IN NORMAL AND ABNORMAL FIBRINOGEN 201
28. SIMULTANEOUS CLINICAL EVALUATION OF RADIOIMMUNOASSAYS FOR FIBRINOPEPTIDES AND g-THROMBOGLOBULIN 207
29. ANALYSIS OF HUMAN FIBRINOPEPTIDES BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY : QUANTITATIVE DETERMINATION AND KINETICS OF RELEASE 217
30. V. FIBRINOGEN - FIBRIN COMPLEXES
31. SOLUBLE FIBRINOGEN-FIBRIN COMPLEXES IN PLASMA AT 37°C 229
32. SOLUBLE DES-AA FIBRIN CLEARANCE IN HEALTHY HUMAN SUBJECTS 231
33. COMPLEX FORMATION OF SOLUBLE FIBRIN POLYMERS WITH AGAROSECOUPLED FIBRINOGEN AND FIBRIN WITH REGARD TO THEIR MOLECULAR WEIGHT 233
34. TEMPERATURE-DEPENDENT REVERSIBLE ASSOCIATION AND DISSOCIATION OF SOLUBLE FIBRIN IN PLASMA 237
35. NO COMPLEX FORMATION OF DES-AB FIBRIN WITH FIBRINOGEN INVESTIGATED BY THE HUMMEL AND DREYER PROCEDURE 249
36. VI. FIBRIN(OGEN) DEGRADATION AND CROSSLINKED FIBRIN DERIVATIVES
37. ON THE STRUCTURE OF D-FRAGMENTS OF HUMAN FIBRINOGEN AND FIBRIN 255
38. ROLE OF THE C-TERMINUS OF THE FIBRINOGEN y-CHAIN IN FIBRINOGEN Ca²⁺ BINDING AND IN FIBRIN POLYMERIZATION 265
39. FIBRINOGEN DEGRADATION BY GRANULOCYTE ELASTÄSE AND CATHEPSIN G - GENERATION OF FIBRINOGEN DEGRADATION PRODUCTS WITH ANTICOAGULANT PROPERTIES 271
40. A SIMPLE METHOD FOR QUANTIFICATION OF FIBRINOGEN-CHAINS AND EARLY SPLIT-PRODUCTS IN SDS-DISC-ELECTROPHORESIS 285
41. HOMOLOGUES OF FIBRIN X OLIGOMERS 291
42. FIBRIN FRAGMENTATION BY PLASMIN: MOLECULAR CONSIDERATIONS AND THEIR RELEVANCE TO DIC AND THROMBOSIS 307
43. FIBRINOGEN IN LIVER CIRRHOSIS. FIBRIN MONOMER COMPLEXES AND DYSFIBRINOGENAEMIA WITH HIGH SIALIC ACID CONTENT 329
44. INFLUENCE OF VARIOUS THROMBIN FORMATION RATES ON THE FIBRIN STABILIZATION PROCESS 339
45. SOME OBSERVATION ON CONCENTRATION AND COAGULABILITY OF FIBRINOGEN IN PATIENTS WITH CANCER, WITH AND WITH3UT METASTASIS 347
46. VII. BIOLOGICAL EFFECTS OF LOW MOLECULAR WEIGHT PEPTIDES AND INTERACTION WITH OTHER PROTEINS
47. EFFECTS OF PEPTIDES DERIVED FROM FIBRINOGEN PROTEOLYSIS ON IMMUNEREACTIONS AND TUMOR GROWTH 355
48. PLASMIN AND ELASTASE INDUCED FIBRIN DEGRADATION PRODUCTS AND THEIR ACTION ON VASCULAR PERMEABILITY: AN EXPERIMENTAL STUDY 361
49. THE EFFECT OF REPEATED INJECTIONS OF FIBRINOPEPTIDES A AND B ON EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN RATS AND GUINEA PIGS 365
50. INTERACTION OF FIBRINOGEN WITH ITS PLATELET RECEPTOR REQUIRES THE NATIVE STRUCTURE OF THE MOLECULE AND DIVALENT IONS 369
51. STUDIES ON THE BINDING OF TISSUE PLASMINOGEN ACTIVATOR TO FIBRINOGEN AND FIBRIN 377
52. FIBRIN BINDING AND TRANSAMIDATION REACTIVE DOMAINS OF FIBRONECTIN 389
53. AUTHOR INDEX 397
54. SUBJECT INDEX 399
55. Backmatter 401