ENHANCEMENT OF THE GENOMIC ACTION OF 1,25-DIHYDROXYCHOLECALCIFEROL BY TRIIODOTHYRONINE IS A REGULATORY FACTOR OF INTESTINAL CALCIUM AND PHOSPHATE TRANSPORT

Chapters in this book

1. I-IV I
2. Foreword V
3. OFFICIAL SPONSORS SEVENTH WORKSHOP ON VITAMIN D IX
4. Contents XI
5. TRIBUTE TO Ο. NEAL MILLER XXXIX
6. Chemistry of Vitamin D Seco-Steroids
7. DEVELOPMENT OF SYNTHETIC METHODS FOR FLUORINATED VITAMIN D ANALOGS 3
8. VITAMIN D ANALOGUES: POTENTIAL INHIBITORS OF VITAMIN D METABOLISM 12
9. SYNTHESIS OF 26,27-HEXADEUTERO AND EPIMERIC 26-TRIDEUTERO 1,25-DIHVDROXYCHOLECALCIFEROLS 22
10. CHEMICAL SYNTHESIS OF VITAMIN D ANALOGS WITH SELECTIVE BIOLOGICAL ACTIVITIES 25
11. CHEMISTRY OF VITAMIN D, ITS METABOLITES AND ANALOGS 34
12. A PRACTICAL SYNTHESIS OF 1-ALPHA-OH VITAMIN D3 ANALOGS 43
13. SYNTHESIS OF BIOLOGICALLY ACTIVE CYCLOPROPANE ANALOGUES OF 1α,25-DIHYDROXY- AND 1α-HYDROXY-VITAMIN D3 51
14. ASYMMETRIC SYNTHESIS OF 1α,25-DIHYDROXYVITAMIN D3 AND ANALOGS. 53
15. CHEMICAL SYNTHESIS AND STUDIES OF 9(11)-DEHYDROVITAMIN D AND ITS 11-SUBSTITUTED ANALOGUES 54
16. A- AND C-RING MODIFIED VITAMIN D ANALOGUES: A MECHANISTIC STUDY OF THE PREVITAMIN OF THE [1,7]-SIGMATROPIC HYDROGEN SHIFT D-VITAMIN D EQUILIBRIUM 58
17. SYNTHESIS AND BIOLOGIC EVALUATION OF A SECOND GENERATION PHOTOAFFINITY ANALOG OF 1,25-DIHYDROXYVITAMIN D3. 60
18. SYNTHESIS OF THE UNNATURAL (7Z)-VITAMIN D TRIENE SYSTEM 62
19. NOVEL AND STEREOSELECTIVE SYNTHESES OF 1α-HYDROXYLATED VITAMIN D METABOLITES 64
20. ON OXIDATION OF THE VITAMIN D TRIENE SYSTEM - A SIMPLE AND CONVENIENT ENTRY INTO THE 19-NOR-10-OXO-DERIVATIVES OF VITAMIN D 66
21. SYNTHESIS OF 25-HYDROXYDIHYDROTACHYSTEROL2 68
22. STEREOCHEMISTRY AT C(23) OF 23,25-DIHYDROXY-24-OXOVITAMIN D3 70
23. SYNTHESIS AND BIOLOGICAL ACTIVITY OF HIGHLY ACTIVE VITAMIN D ANALOGS: GENERAL APPROACHES TO THE SYNTHESIS OF BIOLOGICALLY POTENT VITAMIN D STEROLS 72
24. SYNTHESES OF LABELED SIDE CHAINS OF VITAMIN D METABOLITES AND ANALOGS 74
25. SYNTHESIS OF 22-OXA-, AND 20-OXA-ANALOGUES OF VITAMIN D3 76
26. COMPUTER CALCULATIONS OF THE ACTIVE CONFORMATION OF 1,25-DIHYDROXY VITAMIN D3 78
27. Vitamin D Metabolism and Catabolism
28. PRECHOLECALCIFEROL FORMATION BY AN INVERTEBRATE, PSAMMECHINUS MILIARIS 83
29. SPECIES VARIATION OF VITAMIN D METABOLISM AND ACTION: LESSONS TO BE LEARNED FROM FARM ANIMALS. 93
30. METABOLISM OF VITAMIN D IN PHAGOCYTIC CELLS 102
31. EXTRARENAL PRODUCTION OF CALCITRIOL IN CHRONIC RENAL FAILURE 112
32. Metabolism of 1,25(OH)2D3 in Perfused Duodena from Normal Chicks 114
33. Intestinal Metabolism of 25-Hydroxyvitamin D3: Effect of the X-Linked Hyp Mutation and 1,25-Dihydroxyvitamin D3 Treatment 116
34. Biosynthesis of Water-Soluble Metabolites of 1,25-Dihydroxyvitamin D3 by Osteosarcoma UMR-106. 118
35. CONVERSION OF 25-HYDROXYVITAMIN D3 TO 19-NOR-10-OXO-25-HYDROXYVITAMIN D3 BY SOLUBILIZED CHICK KIDNEY MITOCHONDRIA AND BOVINE SERUM ALBUMIN. 120
36. 24-OXIDATION OF 1,25-(ΟΗ)2D3 BY A HUMAN OSTEOSARCOMA CELL LINE, U-20S. 122
37. THE VITAMIN D DEPLETION OF CHRONIC CHOLESTASIS IS INDEPENDENT OF THE HEPATIC METABOLISM OF VITAMIN D3. 124
38. METABOLIC CLEARANCE RATE AND PRODUCTION RATE OF CALCITRIOL IN UREMIA. EFFECTS OF 25(OH)D THERAPY 126
39. MEASUREMENT OF PRODUCTION RATE AND METABOLIC CLEARANCE RATE OF 1,25-DIHYDROXYVITAMIN D3 IN CONSCIOUS RATS USING A SIMPLIFIED PRIMED-INFUSION TECHNIQUE. 128
40. METABOLISM OF 1,25(OH)2D3 AFTER CONSECUTIVE DOSE OF 1αOHD3 AND 1,25(OH)2D3 IN RATS. 130
41. 25-Hydroxyvitamin D3 Sulphate in Human Plasma: Observations Using High Performance-Liquid Chromatography and Gas Chromatography-Mass Spectrometry 132
42. THE EFFECT OF VITAMIN D STATUS OF VITAMIN D METABOLISM IN CHICKS. 135
43. IDENTIFICATION OF A SUBSET OF DAIRY COWS THAT FAIL TO PRODUCE 1,25-DIHYDROXYVITAMIN D (1,25-(OH)2D) AT THE ONSET OF THE HYPOCALCEMIA ASSOCIATED WITH PARTURIENT PARESIS. 137
44. THE INTACT HEPATOCYTE HYPOTHESIS APPLIES TO THE C-25 HYDROXYLATION OF VITAMIN D3 IN ALCOHOLIC CIRRHOSIS 139
45. MECHANISM OF ACTION OF 26,27-HEXAFLUORO-1,25(OH)2D3 141
46. 1α,25(OH)2D3-26,23-LACTONE IS A MAJOR METABOLITE OF 1α,25(OH)2D3 UNDER PHYSIOLOGICAL CONDITIONS. 143
47. 25-HYDROXY-24-OXOVITAMIN D3 IS A NATURAL METABOLITE UNDER PHYSIOLOGICAL CONDITIONS. 145
48. METABOLISM OF 1,25(OH)2D3 AFTER SINGLE INTRAVENOUS OR ORAL DOSE OF 1αOHD3 AND 1,25(OH)2D3 IN RATS. 147
49. ADMINISTRATION OF PHARMACOLOGICAL AMOUNTS OF 25(S),26-DIHYDROXYVITAMIN D3 REDUCES 1,25-DIHYDROXYVITAMIN D3 SYNTHESIS. 149
50. THE EFFECT OF GROWTH HORMONE ON THE PHOSPHATE AND CALCITRIOL RESPONSES TO DIETARY PHOSPHORUS RESTRICTION IN MAN. 151
51. THE EFFECT OF GLUTETHIMIDE ON RAPIDLY REDUCING THE CIRCULATING CONCENTRATIONS OF 1,25-DIHYDROXY VITAMIN D IN HYPERVITAMINOSE D 153
52. Biochemistry and Regulation of Hydroxylases
53. CURRENT MODELS FOR THE STUDY OF THE REGULATION OF 25(OH)D3 METABOLISM 157
54. SOLUBILIZATION AND RECONSTITUTION OF MAMMALIAN 25-OH-VITAMIN D3-24 AND 1α-HYDROXYLASE ACTIVITIES FROM PIG MITOCHONDRIA 166
55. MOLECULAR CHARACTERIZATION OF THE IRON-SULFUR PROTEIN FROM THE PORCINE KIDNEY MITOCHONDRIAL HYDROXYLASE SYSTEM. 168
56. NORMAL REGULATION OF CALCITRIOL PRODUCTION IN GY-MICE: EVIDENCE FOR BIOCHEMICAL HETEROGENEITY IN THE X-LINKED HYPOPHOSPHATEMIC DISEASES. 170
57. REGULATION OF 25-HYDROXYVITAMIN D3 METABOLISM IN MITOCHONDRIA ISOLATED FROM PRIMARY CULTURES OF CHICK KIDNEY CELLS: EFFECTS OF PARATHYROID HORMONE AND FORSKOLIN. 172
58. THE STIMULATION OF 25-HYDROXYVITAMIN D-1-HYDROXYLASE BY DIETARY PHOSPHORUS RESTRICTION REQUIRES INSULIN-LIKE GROWTH FACTOR-I (IGF-I). 174
59. PHORBOLIC ESTER EFFECT ON RAT RENAL 25-OHD3 1-HYDROXYLASE ACTIVITY: POSSIBLE ROLE OF Ca, PHOSPHOLIPID-DEPENDENT PROTEINKINASE. 177
60. IN VITRO MEASUREMENT OF 25-HYDROXYVITAMIN D-1-HYDROXYLASE (1-OKASE) ACTIVITY IN LACTATING MICE USING A NEW, COMMERCIALLY AVAILABLE ASSAY. 179
61. INHIBITION OF RENAL MITOCHONDRIAL 25(OH)D-1-HYDROXYLASE ACTIVITY BY PHOSPHORYLATION OF FERREDOXIN. 181
62. PROTOCOL FOR PARTIAL PURIFICATION OF THE CYTOCHROME P-450-1α. 183
63. PURIFICATION OF A CYTOCHROME P-450 FROM RABBIT LIVER MITOCHONDRIA CATALYZING 25-HYDROXYLATION OF VITAMIN D3 185
64. ACUTE CHANGES IN PERFUSATE CALCIUM AND PHOSPHORUS DO NOT AFFECT 1-α-HYDROXYLASE ACTIVITY IN THE ISOLATED PERFUSED RAT KIDNEY. 187
65. DOES THE ADMINISTRATION OF PHOSPHATE INCREASE THE SERUM 1,25(0H)2D CONCENTRATION IN X-LINKED HYPOPHOSPHATEMIC RICKETS? 189
66. ASCORBIC ACID EFFECTS ON 1-OHase AND 24-OHase ACTIVITY IN KIDNEY AND 1,25(OH)2D3 RECEPTOR BINDING IN INTESTINAL MUCOSA OF GUINEA-PIGS. 191
67. METABOLISM IN VITRO OF 25-HYDROXYVITAMIN D3 BY CULTURED PORCINE ALVEOLAR MACROPHAGES. 194
68. EVIDENCE THAT RAT KIDNEY 25-HYDROXYVIΤΑΜIN D-24-HYDROXYLASE CAN EXIST IN AN INACTIVE STATE. 196
69. 25 HYDROXYVITAMIN D, 1-HYDROXYLASE (1-OH-LASE) ACTIVITY IN RHESUS MONKEYS. 198
70. 2 5-HYDROXYLATION OF VITAMIN D3 BY A CYTOCHROME P-450 FROM PIG KIDNEY MICROSOMES 200
71. Receptors for 1,25(OH)2D3 (Biochemistry and Molecular Biology)
72. VITAMIN D3 RECEPTORS: MOLECULAR STRUCTURE OF THE PROTEIN AND ITS CHROMOSOMAL GENE 215
73. DEFINITION OF THE FUNCTIONAL DOMAINS OF THE VITAMIN D3 RECEPTOR 225
74. HYPERTHYROIDISM INCREASES NUCLEAR 1,25-DIHYDROXYVITAMIN D3 BINDING IN FEMALE RAT LIVER. 227
75. CHANGES IN INTESTINAL 1,25-DIHYDROXYVITAMIN D RECEPTOR DURING AGING, GESTATION AND PREGNANCY IN RATS. 229
76. POSITIVE COOPERATIVITY OF THE RAT INTESTINAL 1,25 DIHYDROXYVITAMIN D RECEPTOR 231
77. KETOCONAZOLE POTENTIATES 1,25-(OH)2D3-DIRECTED UPREGULATION OF 1,25-(OH)2D3-RECEPTORS IN RAT INTESTINE AND BONE. 233
78. 1α,25-DIHYDROXYVITAMIN D3 RECEPTOR DEFECTS IN LYMPHOCYTE CELL LINES FROM VITAMIN D-DEPENDENT RICKETS TYPE II 235
79. VITAMIN Κ ROLE IN THE INTERACTION OP 1,25(OH)2D3 RECEPTORS WITH DNA. 237
80. ADMINISTRATION OF 1,25-DIHYDROXYVITAMIN D3 (1,25-(OH)2D3) UPREGULATES NUMBER OF RECEPTORS FOR 1,25-(OH)2D IN COLON MUCOSA OF DAIRY COWS. 240
81. CHARACTERIZATION OF THE CHROMOSOMAL GENE OF THE MOUSE VITAMIN D RECEPTOR 242
82. REGULATION OF VITAMIN D ACTION IN RAT OSTEOGENIC SARCOMA CELLS (UMR-106). 244
83. DUODENUM AND COLON 1,25-DIHYDROXYVITAMIN D (1,25-(OH)2D) RECEPTOR CONCENTRATION IS INCREASED DURING LACTATION IN THE RAT. 246
84. THE 1,25-DIHYDROXYCHOLECALCIFEROL LEVEL IN PLASMA DOES NOT INFLUENCE THE PROPERTIES OF ITS INTESTINAL RECEPTOR IN PIGLETS. 248
85. THE NUMBER OF 1,25-DIHYDROXYVITAMIN D RECEPTORS IN RAT INTESTINAL MUCOSA HAVE BEEN MARKEDLY UNDERESTIMATED. 250
86. DNA BINDING PROPERTY OF VITAMIN D3 RECEPTORS ASSOCIATED WITH 26,26,26,27, 27,27-HEXAFLUORO-1,25(OH)2D3. 256
87. VITAMIN D3 BINDING PROTEIN OF PHASEOLUS VULGARIS ROOTS. BIOCHEMICAL AND FUNCTIONAL CHARACTERIZATION. 258
88. Cell Differentiation Hematopoiesis Immunology
89. INTERACTION BETWEEN THE HEMATOPOIETIC SYSTEM AND THE VITAMIN D ENDOCRINE SYSTEM 263
90. 1,25-(OH)2D3 AND GENE EXPRESSION DURING HL-60 DIFFERENTIATION. 267
91. Vitamin D: Α Steroid Hormone of the Immune System, by the Immune System, for the Immune System. 276
92. IMMUNOREGULATORY PROPERTIES OF 1,25(CH)2D3: CELLULAR REQUIREMENTS AND MECHANISMS 282
93. 1,25-DIHYDROXYVITAMIN D3 AND THE REGULATION OF CANCER CELL REPLICATION. 291
94. MC 903 - A NOVEL VITAMIN D ANALOGUE WITH POTENT EFFECTS ON CELL PROLIFERATION AND CELL DIFFERENTIATION. 300
95. 1α,25-DIHYDROXY-22-OXAVITAMIN D3: A NEW SYNTHETIC ANALOGUE OF VITAMIN D3 HAVING POTENT DIFFERENTIATION-INDUCING ACTIVITY WITHOUT INDUCING HYPERCALCEMIA IN VIVO AND IN VITRO. 310
96. MECHANISMS OF CELL FUSION INDUCED BY 1α,25-DIHYDROXYVITAMIN D3 320
97. 1,25(OH)2D3 PROMOTES DIFFERENTIATION OF RESTING CHONDROCYTES TO HYPERTROPHIC CELLS IN VITRO: A MODEL SYSTEM FOR EVALUATING THE POTENCY OF VITAMIN D ANALOGS 330
98. 1α,25-DIHYDROXY VITAMIN D3 SYNTHESIS BY SYNOVIAL FLUID MACROPHAGES IN ARTHRITIC DISEASE 332
99. 1,25-DIHYDROXYVIΤΑΜIN-D3 PROLONGS RAT CARDIAC ALLOGRAFT SURVIVAL 334
100. 1,25-DIHYDROXYVITAMIN D3 AS A SYNERGISTIC AGENT OF IN VITRO CYCLOSPORIN A-INDUCED SUPPRESSIVE ACTIVITY IN RHEUMATOID ARTHRITIS. 336
101. CHANGES IN PHOSPHOINOSITIDE METABOLISM DURING 1,25(OH)2D3 INDUCED CELL DIFFERENTIATION 338
102. INCREASE IN [Ca2+]i IN CULTURED HUMAN KERATINOCYTES BY 1,25(OH)2D3 IS CALCIUM DEPENDENT AND COINCIDES WITH AN INCREASE IN PHOSPHATIDYLINOSITOL METABOLISM. 340
103. THE EFFECTS OF 1α,25(OH)2D3, DILTIAZEM (D-CIS, L-CIS) ON INDUCTION OF DIFFERENTIATION OF HL-60 CELLS. 342
104. 1α-HYDROXYLATED VITAMIN D METABOLITES PROMOTE DIFFERENTIATION AND 24,25-DIHYDROXY VITAMIN D SYNTHESIS IN HUMAN LEUKAEMIA (HL60) CELLS. 344
105. 1,25 DIHYDROXYVITAMIN-D3 PROLONGS SKIN GRAFT SURVIVAL IN MICE 346
106. EFFECTS OF 1,25(OH)2D3 ON MYELOPOIESIS AND Β LYMPHOPOIESIS IN LONGTERM MARROW CULTURES. 348
107. VITAMIN D-DEFICIENCY DISTURBS THE DIFFERENTIATION PROCESS IN THE DENTAL PAPILLA : AN ULTRASTRUCTURAL STUDY. 350
108. 1,25-DIHYDROXYVIΤΑΜIN D3 INHIBITS DELAYED-TYPE HYPERSENSITIVITY MEDIATED BY T-CELL CLONES INDUCING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS 352
109. 1,25-DIHYDROXYVITAMIN D3 ACTS DIRECTLY ON HUMAN LYMPHOCYTES AND INTERFERES WITH THE CELLULAR RESPONSE TO INTERLEUKIN-2. 354
110. 1α,25-DIHYDROXYVITAMIN D3 SYNTHESIS BY NORMAL AND MYELOFIBROTIC HUMAN SPLEEN CELLS. 356
111. PRETREATMENT OF Τ CELL OR MONOCYTIC CELL LINES WITH 1,25(OH)2D3 MARKEDLY INCREASES IL2 or IL1 mRNA LEVELS FOLLOWING CELL ACTIVATION 358
112. PHORBOL ESTER STIMULATION OF 250H-VITAMIN D 1-HYDROXYLASE ACTIVITY IN THE MONOBLASTIC CELL LINE U937 360
113. AN EVALUATION OF ANALOGS OF 1,25-DIHYDROXYVITAMIN D3 ON THE INHIBITION OF PROLIFERATION AND INDUCTION OF TERMINAL DIFFERENTIATION IN CULTURED HUMAN NORMAL KERATINOCYTES. 362
114. 1,25-DIHYDROXYVITAMIN D3 POTENTIATES THE IMMUNOMODULATORY ACTION OF PROSTAGLANDIN E2 AND HISTAMINE BY INTERACTING WITH cAMP-DEPENDENT PATHWAYS. 364
115. EFFECTS OF 1,25-DIHYDROXYVITAMIN D3 AND OTHER STEROID HORMONES ON PROTEIN SYNTHESES IN PRIMARY CULTURES OF ADULT RAT HEPATOCYTES 366
116. THE SEPARATION OF KERATINOCYTE POPULATIONS USING A GRAVITY SEDIMENTATION CHAMBER : A POTENTIAL TOOL FOR THE STUDY OF 1,25(OH)2D3 ACTION ON CELLS AT DIFFERENT STAGES OF DIFFERENTIATION. 368
117. EVIDENCE THAT OSTEOINDUCTION BY IMPLANTS OF DEMINERALIZED ALLOGENIC BONE MATRIX IS DIMINISHED IN VITAMIN D-DEFICIENT NORMOCALCEMIC RATS. 370
118. 1,25-(OH)2D3 BINDS SPECIFICALLY TO RAT VASCULAR SMOOTH MUSCLE CELLS AND STIMULATES THEIR PROLIFERATION IN VITRO. 372
119. INVOLVEMENT OF INTRACELLULAR FREE CALCIUM AND pH IN THE EFFECT OF 1.25(OH)2D3 ON LEUKEMIC CELLS. 374
120. Gene Regulation by 1,25(OH)2D3
121. MDDIFICATIONS IN THE INTERACTIONS OF REGULATORY PROTEINS WTIH THE PROMOTER OF A CELL GROWTH REGULATED GENE INDUCED TO DIFFERENTIATE BY 1,25 (OH)2D3 379
122. INHIBITION OF 1,25-DIHYDROXYVITAMIN D3 STIMULATED BGP mRNA SYNTHESIS IN ROS 17/2 CELLS AFTER PROLONGED TREATMENT WITH 1,25- DIHYDROXYVITAMIN D3 381
123. 1,25(OH)2D REGULATES ONCOGENE EXPRESSION IN U937 CELLS. 383
124. REGULATION OF CALBINDIN-D9K (CaBP9K) GENE EXPRESSION BY 1,25-DIHYDROXY-CHOLECALCIFEROL AND CALCIUM IN ORGAN CULTURES OF FETAL RAT DUODENUM. 385
125. ENHANCEMENT OF THE GENOMIC ACTION OF 1,25-DIHYDROXYCHOLECALCIFEROL BY TRIIODOTHYRONINE IS A REGULATORY FACTOR OF INTESTINAL CALCIUM AND PHOSPHATE TRANSPORT 387
126. INFLUENCE OF VITAMIN D3 UPON THE EXPRESSION OF PEP-19, A PUTATIVE NEURON-SPECIFIC CALCIUM-BINDING PROTEIN. 389
127. INDUCTION OF OSTEOCALCIN SYNTHESIS IN HUMAN OSTEOSARCOMA CELLS BY 1,25-DIHYDROXYVITAMIN D AND 24,24-DIFLUORO-l,25-DIHYDROXYVITAMIN D 391
128. Biological Actions of Vitamin D Metabolites
129. THE ROLE OF 24,25 DIHYDROXY VITAMIN D3 DURING DEVELOPMENT OF SKELETAL AND NON-SKELETAL TISSUES 395
130. THE REGULATION OF INTRACELLULAR IONIZED CALCIUM BY CALCITRIOL 405
131. RAPID ACTION OF 1,25(OH)2D3 IN LIVER CELLS. 416
132. 1,25(OH)2D3 DIRECTLY MODULATES HUMAN MELANOCYTE FUNCTION 419
133. STIMULATION OF SYNTHESIS OF MYOBLAST MEMBRANE PROTEINS BY 25-HYDROXY-VITAMIN D3 421
134. STIMULATION OF RAT DUODENAL BRUSH BORDER ALKALINE PHOSPHATASE ACTIVITY WITHIN 10 MINUTES OF IN VIVO CALCITRIOL ADMINISTRATION. 423
135. 1,25-DIHYDROXY-VITAMIN D3 INCREASES 3H-THYMIDINE-UPTAKE AND POTENTIATES THE EFFECT OF EPIDERMAL GROWTH FACTOR IN FRTL-5 CELLS 425
136. 1,25-DIHYDROXYVITAMIN D3 STIMULATES 45Ca2+ UPTAKE BY CULTURED VASCULAR SMOOTH MUSCLE CELLS DERIVED FROM RAT AORTA 427
137. 1,25(OH)2D3 ACTIVATES PROTEIN KINASE C IN RAT COLONIC CRYPTS. 429
138. FREE 1,25-DIHYDROXYVITAMIN D3 LEVELS IN NORMAL AND RACHITIC PIGLETS. 431
139. 1,25(OH)2VITAMIN D3 ANALOGS: COMPARISON OF 1,25(OH)2D3 RECEPTOR LIGAND SPECIFICITY AND BIOLOGICAL ACTIVITY IN THE CHICK AND HUMAN PROMYELOCYTE (HL-60) CELLS. 433
140. 24,25-DIHYDROXY-VITAMIN D3 BINDING IN BOVINE THYROID 435
141. EFFECTS OF 1,25-DIHYDROXY-VITAMIN D3 ON PHOSPHOLIPID METABOLISM IN CULTURED MYOBLASTS. 437
142. VITAMIN D STATUS AND INTESTINAL ABSORPTION OF ALUMINUM IN RATS WITH NORMAL OR REDUCED RENAL FUNCTION. 439
143. DIRECT EFFECT OF VITAMIN D METABOLITES ON MATRIX VESICLE ALKALINE PHOSPHATASE 441
144. PROLIFERATIVE EFFECTS OF 1,25-DIHYDROCHOLECALCIFEROL (1,25-DHCC), 24,25- DIHYDROXYCHOLECALCIFEROL (24,25-DHCC), 25-HYDROXYCHOLECALCIFEROL (25-HCC) AND K-HYDROXYCHOLECALCIFEROL (U-HCC) 443
145. THE EFFECT OF PERTUSSIS TOXIN ON PTH- AND 1α,25(OH)2 D3 - INDUCED DESENSITIZATION IN RAT OSTEOBLASTS OF THE cAMP RESPONSE TO PTH. 445
146. SYNERGISTIC EFFECTS OF VITAMIN D3 METABOLITES. 448
147. 25(OH)D3, BUT NOT 1,25(OH)2D3 CURES OSTEOMALACIA IN MARMOSET MONKEYS. 450
148. ACUTE RELEASE OF BIOACTIVE PTH BY INTRAVENOUS 1,25 DIHIDROCHOLECALCIFEROL IN CHRONIC RENAL FAILURE. 452
149. 1,25-DIHYDROXY-VITAMIN D3 INCREASES CALMODULIN BINDING TO SKELETAL MUSCLE MEMBRANE PROTEINS. 454
150. HYPOPARATHYROIDISM IN HEREDITARY RESISTANCE TO 1,25(OH)2D DURING LONG-TERM TREATMENT WITH EXCESSIVE DOSES OF VITAMIN D3. 456
151. EFFECTS OF 1-alpha-OHD3 ON INTESTINAL RADIOCALCIUM ABSORPTION AND SERUM BONE GLA PROTEIN IN NORMAL SUBJECTS AND OSTEOPOROTIC WOMEN. 458
152. RAPID EFFECTS OF 1,25(OH)2-VITAMIN D3 ON CALCIUM UPTAKE BY CARDIAC MUSCLE 460
153. 1α, 25-DIHYDROXYVITAMIN D3 IN RAT SKIN: IDENTIFICATION, QUANTIFICATION AND BIOLOGICAL FUNCTION. 462
154. 1,25-DIHYDROXYVITAMIN D3 STIMULATES Ca-ATPase AND REGULATES CELLULAR CALCIUM IN VASCULAR SMOOTH MUSCLE CELLS 464
155. Calbindins (Biochemistry, Molecular Biology, Biological Actions)
156. CALBINDIN-D9K (CaBP9K) GENE : EXPRESSION, REGULATION, STRUCTURE AND EVOLUTION. 469
157. 1,25-DIHYDROXYVITAMIN D3, ITS RECEPTOR AND THE EUKARYOTIC GENOME 479
158. STRUCTURE AND EVOLUTION OF THE CHICK CALBINDIN GENE 489
159. REGULATION OF RAT CALBINDIN-D28k GENE EXPRESSION 499
160. MOLECULAR CLONING AND SEQUENCING OF CALBINDIN-D9K CDNA FROM MOUSE PLACENTA. 507
161. HIGH CONSERVATION OF CALBINDIN D28 IN EVOLUTION; IMPLICATIONS FOR ITS FUNCTION. 509
162. FUNCTIONAL ANALYSIS OF THE PROMOTER REGION OF THE GENE ENCODING CHICKEN CALBINDIN-D28K 512
163. CELLULAR LOCALIZATION OF BRAIN CALBINDIN-D28k 514
164. VITAMIN D DEPENDENCE OF CALBINDIN D 9K AND CALBINDIN D 28K SYNTHESIS IN VARIOUS RAT TISSUES. 516
165. IMMUNOHISTOCHEMICAL DEMONSTRATION OF VITAMIN D-DEPENDENT CALCIUM-BINDING PROTEIN, CALBINDIN-D 28K (CaBP28K) IN THE SPINAL CORD MOTONEURONS OF TELEOST FISH. 518
166. IN SITU HYBRIDIZATION OF THE RAT CALBINDIN D-28 520
167. SPECTROSCOPIC STUDIES ON CHICK INTESTINAL CALBINDIN-D28K SUGGEST THE EXISTENCE OF 4-6 FUNCTIONAL CA2+ BINDING SITES 523
168. EVOLUTION OF THE "EF-HAND" CaBP FAMILY : ΕΧΟΝ SHUFFLING AND INTRON INSERTION. 525
169. EFFECTS OF ALTERED THYROID STATES AND UNDERNUTRITION ON CALBINDIN-D28K (CALCIUM-BINDING PROTEIN) IN THE HIPPOCAMPAL FORMATION OF THE DEVELOPING RAT. 527
170. EXPRESSION OF CALBINDIN D DECREASES WITH AGE IN INTESTINE AND KIDNEY. 529
171. EVIDENCE FOR TISSUE-SPECIFIC REGULATION OF CALBINDIN 28K GENE EXPRESSION IN THE CHICK BY 1,25-DIHYDROXYVITAMIN D3. 531
172. EVIDENCE FOR THE PRESENCE OF TWO "VITAMIN D-DEPENDENT" CALCIUM BINDING PROTEINS IN BRAIN 533
173. THE HUMAN CALBINDIN D28 GENE. 535
174. EFFECT OF VITAMIN D DEFICIENCY AND 1,25-DIHYDROXYCHOIECALCIFEROL TREATMENT ON EPIDERMAL CALCIUM BINDING PROTEIN (ECaBP) RNA ACTIVITY. 537
175. COMPLETE AMINO ACID SEQUENCES OF MOUSE CALBINDIN-D9K ISOFORMS DETERMINED BY TANDEM MASS SPECTROMETRY: PROTEIN MODIFICATION BY INTERNAL INSERTION OF A SINGLE AMINO ACID. 539
176. DEVELOPMENTAL PATTERN AND VITAMIN D-DEPENDENCY OF THE CALBINDINS CaBP 9KDa AND CaBP 28KDa IN THE AMELOBLASTS OF RODENT TEETH : AN IMMUNOCYTOCHEMICAL STUDY. 541
177. CALBINDIN (CaBP28kDa) LOCALIZATION IN THE PERIPHERAL VESTIBULAR SYSTEM OF VARIOUS VERTEBRATES AND COMPARISON WITH ITS DISTRIBUTION DURING DEVELOPMENT OF THE MOUSE AND HUMAN. 543
178. NUCLEAR MAGNETIC RESONANCE AND TERBIUM FLUORESCENCE STUDIES ON THE VITAMIN D-DEPENDENT 28-KILODALT0N CHICK INTESTINAL CALCIUM-BINDING PROTEIN: EVIDENCE FOR CALCIUM-DEPENDENT CONFORMATIONAL CHANGE 545
179. Intestinal and Renal Ca and Ρ Transport
180. TRANSCALTACHIA, VESICULAR CALCIUM TRANSPORT, AND MICROTUBULE-ASSOCIATED CALBINDIN-D28K 549
181. VITAMIN D: EFFECTS ON INTESTINAL CALCIUM ABSORPTION AND PERIPHERAL NERVE FUNCTION. 558
182. ATP-DEPENDENT Ca2+ PUMPS IN ENDOPLASMIC RETICULUM AND PLASMA MEMBRANES ARE NOT AFFECTED BY 9kDa CALBINDIN-D AND VIT.D-DEFICIENCY. 565
183. EFFECTS OF VITAMIN D-DEFICIENCY ON DIFFERENT ACTIVITIES OF THE Ca2+-PUMP IN RAT INTESTINAL BASOLATERAL MEMBRANES. 567
184. ATP-DRIVEN CA2+ PUMPS IN DUODENAL PLASMA MEMBRANES AND ENDOPLASMIC RETICULUM FROM PIGLETS WITH INHERITED RICKETS. 569
185. EFFECT OF 1,25(OH)2D3 ON PHOSPHORUS ABSORPTION IN SHEEP. 571
186. REDUCED CALCIUM ABSORPTION IN X-LINKED HYPOPHOSPHATEMIC RICKETS. 573
187. PHOSPHATE TRANSPORT IN THE INTESTINE OF THE RAT DURING EARLY DEVELOPMENT: ROLE OF VITAMIN D. 575
188. THE 105KD CALMODULIN (CAN) BINDING PROTEIN FROM INTESTINAL BRUSH BORDER MEMBRANE (BBM) IS A CALCIUM TRANSPORT PROTEIN. 577
189. Bone and Action of amin D Metabolites
190. TΗΕ ROLE OF 1,25-DIHYDROXYVITAMIN D3 IN ΊΗΕ GENERATION AND REGULATION OF OSTEOCLASTS. 581
191. VITAMIN D AND OSTEOCLASTOGENESIS 591
192. DENTIN FORMATION AND PLASMA Ca LEVELS IN PTX RATS GIVEN 1.25(OH)2D3 596
193. ELEVATED 1,25-DIHYDROXYVITAMIN D3 AND INTESTINAL CALBINDIN-D9K LEVELS IN THE OSTEOPETROTIC TOOTHLESS RAT. 598
194. INFLUENCE OF 24-FLUORINATED ANALOGUES OF 1,25(OH)2D3 ON BONE MATRIX FORMATION AND BONE RESORPTION IN VITRO 600
195. MODULATION OF THE ACTION OF 1,25(OH)2D3 ON THE OSTEOCALCIN PRODUCTION OF HUMAN OSTEOBLAST-LIKE CELLS BY AGENTS AFFECTING ADENYLATE CYCLASE ACTIVITY. 602
196. INCREASED BONE MINERALS IN VITAMIN D-REPLETE RABBIT BY THE MASSIVE ADMINISTRATION OF 24R,25(OH)2D3 604
197. STUDIES ON THE INTERACTIONS BETWEEN RETINOIC ACID AND 1,25(OH)2D3 ON HUMAN BONE-DERIVED OSTEOBLAST-LIKE CELLS. 606
198. IMMUNOSUPPRESSIVE AGENT CYCLOSPORIN A AND VARIOUS CELL GROWTH FACTORS AFFECT CLONED OSTEOBLASTIC CELL LINE MC3T3-E1 CELLS 608
199. 23(S)25(R)-1,25(OH)2D3-26,23-LACTONE STIMULATES BONE FORMATION IN VIVO. 610
200. SIDE CHAIN MODIFICATIONS INCREASE THE POTENCY OF 1,25- DIHYDROXYCHOLECALCIFEROL (CALCITRIOL) ON HUMAN BONE-DERIVED OSTEOBLAST-LIKE CELLS 612
201. ACTIVITY OF ORNITHINE DECARBOXYLASE IN HARD TISSUE OF VITAMIN D-DEFICIENT AND -REPLETE RATS: EFFECT OF 1,25(0H)2D3, UREMIA AND ALUMINUM INTOXICATION. 614
202. PRODUCTION OF BONE-RESORBING AND OSTEOCLAST-INDUCING FACTORS BY OSTEOBLASTS IN ORGAN CULTURE AND MODULATION BY 1,25(OH)2D3 AND OTHER AGONISTS. 616
203. CIRCULATING OSTEOCALCIN IN MAGNESIUM DEFICIENCY: RESPONSE TO 1,25(OH)2D 618
204. 1,25(OH)2D3 MEDIATES THE EFFECT OF PARATHYROID HORMONE ON NEW BONE FORMATION IN THE RAT 620
205. CIRCULATING OSTEOCALCIN AND 1,25-DIHYDROXYVITAMIN D CONCENTRATIONS AND URINARY γ-CARBOXYGLUTAMIC ACID IN HEALTHY SUBJECTS AND IN PATIENTS WITH METABOLIC BONE DISEASE 622
206. REGULATION OF FIBRONECTIN AND COLLAGEN SYNTHESIS BY 1,25- DIHYDROXYVI TAHIΝ D3. 624
207. 1,25-DIHYDROXYVITAMIN D3 STIMULATES IN VITRO GROWTH OF AVIAN AND MAMMALIAN CARTILAGE 626
208. Nutritional Aspects of Vitamin D
209. MINIMAL INTRAVENOUS VITAMIN D REQUIREMENT DURING PARENTERAL NUTRITION IN INFANCY 631
210. SERUM 25(OH)D3 AND 1,25 (OH)2D3 LEVELS IN WILD AND LABORATORY-BRED WOOD MICE AND BANK VOLES. 633
211. EFFECT OF ACUTE ETHANOL ADMINISTRATION ON THE CIRCULATING PARAMETERS OF BONE MINERAL METABOLISM. 635
212. PLASMA 25-OHVITAMIN D AND PTH IN THE DETECTION OF OSTEOMALACIA IN ASIAN OUTPATIENTS 637
213. THE VITAMIN D CONTENT OF FINNISH HOSPITAL DIETS 640
214. ZINC, VITAMIN D AND BONE MASS IN THE ELDERLY 642
215. THE IMPORTANCE OF VITAMIN C FOR HYDROXYLATION OF VITAMIN D3 TO 1α,25(OH)2D3 AND OF 24R,25(OH)2D3 TO A MORE ACTIVE METABOLITE 644
216. PLASMA MAGNESIUM IN PIGS WITH PSEUDO VITAMIN D DEFICIENT RICKETS; TYPE 1. 654
217. SUNLIGHT DEGRADATION OF VITAMIN D3 656
218. FATTY ACID AND CALCIUM ABSORPTION IN RATS. ROLE OF VITAMIN D 658
219. CLINICAL STUDIES ON THE MECHANISM OF ACQUIRED VITAMIN D DEFICIENCY. 660
220. HOW IS PLASMA 1,25(OH)2D3 CONCENTRATION REGULATED BY DIETARY CALCIUM? 662
221. STUDIES OF RICKETS AND ITS PREVENTION IN BEIJING, CHINA. 664
222. Vitamin D Binding Proteins
223. DBP AND AIDS: FACT OR FICTION ? 669
224. PLASMA VITAMIN D BINDING PROTEIN: PLASMA SCAVENGER FUNCTION AND ORIGIN OF CELL-SURFACE DBP. 674
225. PARTIAL STRUCTURE OF THE GENE FOR HUMAN VITAMIN D-BINDING PROTEIN 680
226. A NEW INTERACTION BETWEEN Gc (VITAMIN D-BINDING PROTEIN) AND UNSATURATED FATTY ACIDS 685
227. TWO 25-HYDROXYCHOLECALCIFEROL-BINDING PROTEINS IN CARP SERUM 692
228. HPLC ANALYSIS OF THE CYANOGEN BROMIDE DIGEST OF HUMAN SERUM VITAMIN D BINDING PROTEIN PHOTOAFFINITY LABELLED WITH A 25-HYDROXYVITAMIN D3 ANALOG. 694
229. EFFECT OF CALCIUM IONS UPON INTERACTIONS BETWEEN GC (VITAMIN D-BINDING) PROTEIN AND CIBACRON BLUE 696
230. PARTIAL PURIFICATION AND PROPERTIES OF BAT VITAMIN D BINDING PROTEIN. 698
231. Assay Methodology: Vitamin D and Metabolites
232. MEASUREMENT OF FREE VITAMIN D METABOLITE LEVELS: BIOLOGICAL AND CLINICAL SIGNIFICANCE. 703
233. THE ASSAY OF CIRCUIATING 1,25 (OH)2D USING NON-END-CAPPED C18 SILICA (C18-OH) : PERFORMANCE AND VALIDATION. 710
234. SIMPLIFIED ASSAYS FOR THE DETERMINATION OF 25-OHD, 24,25-(OH)2D AND 1,25-(OH)2D 720
235. Stable Isotope Dilution Mass Fragmentography for the Measurement of Metabolites of Vitamins D2 and D3 in Human Plasma 727
236. WELL ESTABLISHED PHYSIOLOGICAL FUNCTIONS ARE A PREQUISITE FOR INTRODUCING BIOCHEMICAL PARAMETERS 728
237. THE QUANTIFICATION OF SERUM 25-HYDROXYVITAMIN D USING A COMPETITIVE PROTEIN-BINDING ASSAY AFTER PRELIMINARY PURIFICATION 730
238. CHANGES IN PLASMA LEVELS OF VITAMIN D2, D3 AND THEIR METABOLITES AFTER ORAL ADMINISTRATION OF THE VITAMINS TO VITAMIN D-DEFICIENT RATS. 732
239. AGE-RELATED CHANGES IN IMMUNORADIOMETRIC PTH AND 25-HYDROXYVITAMIN D. 734
240. RELEVANCE OF LONG-TERM VARIATION IN VITAMIN D METABOLITE MEASUREMENTS. IMPLICATIONS FOR LONGITUDINAL STUDY DESIGN. 735
241. Other Basic Science Topics
242. PROSPECTS FOR THE MODELLING OF VITAMIN D ACTIVITY IN MAN 739
243. ISOLATED RAT PROXIMAL TUBULE CELL (PTC) CULTURES ARE CAMP RESPONSIVE TO PARATHYROID HORMONE (PTH), CALCITONIN (CT), AND PROSTAGLANDINS (PGE) BUT NOT TO VASOPRESSIN (VP). 749
244. LIPID COMPOSITION OF BASOLATERAL MEMBRANES FROM RAT ENTEROCYTES: EFFECTS OF VITAMIN D DEFICIENCY. 751
245. POSSIBLE ORIGIN OF EXTREMELY LARGE AMOUNTS OF VITAMIN D3 IN SOME KINDS OF FISH LIVER. 753
246. HEPATOTOXIC EFFECTS OF ALUMINUM: IMPLICATIONS FOR VITAMIN D METABOLISM. 755
247. STUDIES ON KINETICS OF PREVITAMIN D FORMATION REACTION, EFFECTS OF IRRADIATION INTENSITY AT 296nm ON PREVITAMIN D FORMATION 757
248. VITAMIN D DEFICIENCY AND CARDIAC FUNCTION IN ISOLATED CHICK HEARTS 760
249. VITAMIN D EFFECTS ON Ca-STIMULATED ATPase ACTIVITY AND PROTEIN COMPOSITION OF THE RAT'S SKELETAL MUSCLE MIOFIBRILLS. 762
250. THE SPONTANEOUSLY HYPERTENSIVE RAT (SHR): A MODEL OF ABNORMAL VITAMIN D METABOLISM. 763
251. VITAMIN D3 - AND STIGMASTEROL-INDUCED CALMODULIN SYNTHESIS IN PHASEOLUS VULGARIS ROOTS IS MEDIATED BY Ca+2 AND PLANT GROWTH HORMONE-LIKE MITOGENIC STIMULATION. 765
252. A VERY RAPID RECEPTOR MEDIATED ACTION OF 1,25-DIHYDROXYVITAMIN D3:INCREASE OF INTRACELLULAR CYCLIC GMP IN HUMAN SKIN FIBROBLASTS. 767
253. EFFECTS OF VITAMIN D3 METABOLITES ON CYTOSOLIC FREE CALCIUM IN CONFLUENT MOUSE OSTEOBLASTS : A POSSIBLE INVOLVEMENT OF PROTEIN KINASE C. 769
254. Renal Osteodystrophy
255. PLASMA KINETICS OF INTRAVENOUS CALCITRIOL IN NORMAL AND DIALYSED SUBJECTS AND ACUTE EFFECT ON SERUM nPTH LEVELS. 781
256. BIOAVAILABILITY OF CALCITRIOL AFTER ORAL, INTRAVENOUS AND INTRAPERITIONEAL DOSES IN DIALYSIS PATIENTS. 783
257. INTRAVENOUS ADMINISTRATION OF 1α-HYDROXYCHOLECALCIFEROL IN HAEMODIALYSED PATIENTS: DOSE-DEPENDENT INCREASE IN CIRCULATING 1,25-DIHYDROXYCHOLECALCIFEROL 785
258. TEN YEARS EXPERIENCE IN THE PREVENTION OF RENAL OSTEODYSTROPHY BY VITAMIN D-PROPHYLAXIS 787
259. SUCCESSFUL TREATMENT OF RENAL OSTEODYSTROPHY WITH KETO ACIDS (KA) AND VITAMIN D 789
260. EFFECT OF 1,25(OH)2D3 AND 24R,25(OH)2D3 ON THE ACCUMULATION OF ALUMINUM IN BONE IN RATS WITH RENAL FAILURE. 791
261. THE INFLUENCE OF VITAMINS D2 AND D3 ON INTESTINAL CALCIUM ABSORTPION IN PATIENTS WITH RENAL INSUFFICIENCY AND IN DIALYSIS PATIENTS. 793
262. 1α(OH)D3 I.V. SUPPRESSION OF ΡΤΗ SECRETION IN HEMODIALYSIS PATIENTS. 795
263. CLINICAL AND BIOCHEMICAL EFFECTS OF 1,25-DIHYDROXYVITAMIN D3 ADMINISTRATION IN NORMAL AND RENAL IMPAIRED DOGS. 797
264. HYPER- AND NORMO- CALCEMIC DOGS WITH CHRONIC RENAL FAILURE: RELATIONS OF SERUM PTH AND CALCITRIOL TO PTG CA++ SET-POINT 799
265. DIETARY INTAKE AND STATUS OF VITAMIN D AND CALCIUM IN PATIENTS WITH CHRONIC RENAL FAILURE (CRF) TREATED BY HAEMODIALYSIS (HD) AT HOME. 801
266. OSTEOCALCIN (OC) IN ADOLESCENTS WITH ADVANCED RENAL FAILURE 803
267. Osteoporosis
268. LONG-TERM CALCITRIOL TREATMENT IN POST-MENOPAUSAL OSTEOPOROSIS: FOLLOW-UP OF TWO HUNDRED PATIENTS. 807
269. OSTEOPOROSIS AND VITAMIN D METABOLISM: THE STATE OF OUR KNOWLEDGE AS OF 1988. 817
270. THE RATIONALE FOR CALCITRIOL THERAPY IN OSTEOPOROSIS 826
271. CALCITRIOL THERAPY IN THE MANAGEMENT OF OSTEOPOROSIS. 836
272. ALFACALCIDOL IN PREDNISONE TREATMENT:EFFECT ON BONE MINERAL CONTENT IN LUMBAR SPINE AND FEMUR. 838
273. DECREASE OF PLASMA 1,25-DIHYDROXYVITAMIN D3 (1,25(OH)2D3) AND LOSS OF SPINAL BONE MASS IN WOMEN DURING TREATMENT WITH GnRH AGONISTS. 840
274. EFFECT OF 26,27-HEXAFLUORO-1,25-DIHYDROXYVITAMIN D3 ( F6-1,25(OH)2D3 ) ON OSTEOPOROSIS INDUCED BY IMMOBILIZATION COMBINED WITH OVARIECTOMY IN THE RATS. 842
275. SOME BIOCHEMICAL MARKERS IN DISTAL FORE-ARM AND HIP FRACTURES 844
276. THE SHORT TERM EFFECTS OF ALFACALCIDOL IN ELDERLY OSTEOPOROTIC WOMEN. 846
277. CALCITONIN SECRETION IN OSTEOPOROSIS OF TURNER SYNDROME. 848
278. DETERMINANTS OF CALCIUM MALABSORPTION IN POSTMENOPAUSAL OSTEOPOROSIS 850
279. Sarcoidosis
280. REGULATED EXPRESSION OF THE SARCOID MACROPHAGE 25-HYDROXYVITAMIN D-1-HYDROXYLATION REACTION. 855
281. ACCENTUATED TRANSPLEURAL GRADIENT OF "TOTAL" AND "FREE" 1,25-DIHYDROXYVITAMIN D IN PATIENTS WITH TUBERCULOUS PLEURITIS. 857
282. THE EFFECTS OF KETOCONAZOLE AND METYRAPONE ON ACTIVATED ALVEOLAR MACROPHAGES 859
283. 1,25(OH)2D3 PRODUCTION BY LUNG Τ LYMPHOCYTES FROM TUBERCULOSIS PATIENTS. 861
284. Cancer and Vitamin D
285. TREATMENT OF MYELODYSPLASTIC SYNDROME AND AML WITH 1α HYDROXYVITAMIN D3 865
286. NUDE MOUSE MODEL (CAC-8) OF HUMORAL HYPERCALCEMIA OF MALIGNANCY (HHM) WITH INCREASED SERUM LEVELS OF 1,25-DIHYDROXYCHOLECALCIFEROL (1,25(OH)2D): IN VIVO AND IN VITRO STUDIES 867
287. EFFECTS OF TREATMENT WITH THE BISPHOSPHONATE APD ON 1,25-DIHYDROXYVITAMIN D IN PATIENTS WITH MALIGNANT HYPERCALCAEMIA. 869
288. EFFECT OF 1αHYDROXYVITAMIN D3 ON GROWTH OF NITROSOMETHYLUREA-INDUCED RAT MAMMARY TUMORS. 871
289. Diabetes and Vitamin D
290. INTERACTION BETWEEN VITAMIN D, INSULIN AND DIABETES MELLITUS 875
291. ENDOGENOUS DIABETES DECREASES THE NUMBER OF 1,25-DIHYDROXYVITAMIN D3 RECEPTORS IN BOTH INTESTINE AND KIDNEY. 885
292. PLASMA CONCENTRATIONS OF VITAMIN D METABOLITES IN NEWLY DIAGNOSED YOUNG INSULIN-DEPENDENT DIABETICS BEFORE AND AFTER INSULIN TREATMENT. 887
293. THE EFFECT OF HYPOCALCEMIA AND VITAMIN D-DEFICIENCY ON GLUCOSE UTILIZATION IN PIGLETS. 889
294. VITAMIN D-INDUCED INCREASE IN CALCIUM CONTENT IN SECRETORY GRANULES OF Β CELLS PLAYS A ROLE IN RECOVERY OF INSULIN SECRETION IN VITAMIN D-DEFICIENT RATS 891
295. INCREASE IN INSULIN RESPONSE TO GLUCAGON FOLLOWING UV-B IRRADIATION IN HEALTHY ADULTS. 893
296. Gerontology and Vitamin D
297. SERUM 1,25(OH)2D3 IN THE ELDERLY AND OSTEOPOROTIC SUBJECTS FROM SOUTHERN ITALY. A PRELIMINARY REPORT. 897
298. EFFECT OF AGE ON THE RAT INTESTINAL 1,25(OH)2D3 RECEPTOR 899
299. EFFECT OF AGE AND 1,25(OH)2D3 ON CALCIUM UPTAKE IN RAT DUODENUM CELLS 901
300. LOW SERUM CONCENTRATIONS OF 25-HYDROXYVITAMIN D, SELENIUM AND OSTEOCALCIN IN FINNISH ELDERLY MEN 903
301. RESPONSE OF THE SERUM LEVEL OF 1,25-(OH)2D TO RESTRICTION OF DIETARY PHOSPHORUS: EFFECT OF ADVANCED AGE. 905
302. INTESTINAL END-ORGAN RESISTANCE TO 1,25-DIHYDROXYVITAMIN D STIMULATION OF CALCIUM ABSORPTION IN THE SENESCENT RAT 907
303. Pregnancy/Neonatology
304. SERUM VITAMIN D, 25-OHD, AND 1,25(OH)2D, BONE MINERAL CONTENT (BMC) AND MINERAL HOMEOSTASIS IN PREMATURE INFANTS FED HIGH MINERAL PREMATURE FORMULA. 911
305. NORMAL PLASMA 1,25(OH)2D3 IN Α BREAST FED PREMATURE INFANT WITH EARLY HYPOPHOSPHATEMIA RICKETS. 913
306. CHANGES IN 1,25-DIHYDROXYVITAMIN D3 RECEPTOR (1,25 DR) CONTENT OF RAT MAMMARY GLAND DURING PREGNANCY AND LACTATION. 915
307. CONCENTRATIONS OF VITAMIN D METABOLITES IN AMNIOTIC FLUID AND SERUM DURING PREGNANCY 917
308. 1,25-(OH)2D3 AND OSTEOCALCIN CONCENTRATIONS IN FETUSES AND NEONATES FROM RATS FED TWO DIFFERENT CALCIUM-PHOSPHATE DIETS 919
309. INTACT PTH AND VITAMIN D METABOLITES IN EARLY NEONATAL HYPOCALCEMIA. 921
310. Other Clinical Topics
311. VITAMIN D AND THE SKIN: SITE OF SYNTHESIS, TARGET TISSUE, AND NEW THERAPEUTIC APPROACH FOR PSORIASIS. 925
312. INBORN ERRORS IN VITAMIN D METABOLISM - THEIR CONTRIBUTION TO THE UNDERSTANDING OF VITAMIN D METABOLISM. 935
313. VITAMIN D AND HUMAN ANTITUBERCULOSIS IMMUNITY. 948
314. SUCCESSFUL TREATMENT OF PSORIASIS WITH TOPICAL APPLICATION OF THE ACTIVE VITAMIN D3 ANALOG, 1α,24-DIHYDROXYCHOLECALCIFEROL (TV-02). 958
315. EVIDENCE THAT ALTERATION OF THE VITAMIN D-ENDOCRINE SYSTEM IN OBESITY RESULTS FROM VITAMIN D DEFICIENCY. 968
316. ABNORMAL 1,25(OH)2D3 RECEPTOR RELATION OF PARATHYROID GLAND IN LEAD INTOXICATION 976
317. HYPOCALCEMIA AND DECREASED 1,25(OH)2D BLOOD LEVELS IN SEPTIC PATIENTS. 977
318. SERUM VITAMIN D AND CALCIUM METABOLISM IN TUBERCULOSIS PATIENTS RESIDENT IN TWO TROPICAL ENVIRONMENTS 979
319. ABNORMAL VITAMIN D METABOLISM IN PRIMARY ALDOSTERONISM AND EXPERIMENTAL MINERALOCORTICOID EXCESS. 981
320. VITAMIN D METABOLITES AND INTACT PTH IN SPASMOPHILIA. 983
321. VITAMIN D STATUS IN PATIENTS WITH CYSTIC FIBROSIS: SEASONAL VARIATIONS AND THE IMPORTANCE OF VITAMIN D SUPPLEMENTATION: 985
322. AN EPIDEMIOLOGICAL ASSOCIATION BETWEEN VITAMIN D DEFICIENCY AND TUBERCULOSIS 987
323. CONVERSION OF 1α-OHD3 INTO 1,25(OH)2D3 IN NORMAL SUBJECTS, CIRRHOTIC PATIENTS AND POSTMENOPAUSAL OSTEOPOROTIC WOMEN 989
324. THE ROLE OF 1,25 DIHYDROXYVITAMIN D IN SALT SENSITIVE ESSENTIAL HYPERTENSION:EFFECTS OF CALCIUM CHANNEL BLOCKADE 991
325. VITAMIN D3 INDUCED GLYCOLIC ACIDURIA IN AN EXPERIMENTAL STONE MODEL 993
326. VITAMIN D METABOLISM IN BENIGN TRANSIENT HYPERPHOSPHATASAEMIA 995
327. SERUM CALCIUM CAN MODULATE THE PRODUCTION OF 1,25-DIHYDROXYVITAMIN D INDEPENDENTLY OF PTH IN MAN 997
328. AGE-DEPENDENT CHANGES OF VITAMIN D STATUS AND 1,25(OH)2D3 RECEPTOR EXPRESSION IN SPONTANEOUSLY HYPERTENSIVE (SH) RATS 999
329. BEHAVIORAL CHANGES IN CHRONICALLY D-HYPERVITAMINOTIC ANIMALS 1001
330. 1,25-DIHYDROXYVITAMIN D3 IS AN EFFECTIVE THERAPEUTIC AGENT FOR THE TREATMENT OF PSORIASIS VULGARIS AND ERYTHRODERMA PSORIASIS 1007
331. VITAMIN D, CALCIUM AND HYPERTENSION 1009
332. DIETARY VITAMIN D LEVEL AND MINERAL (P, Ca) ABSORPTION IN PIGS FED PHYTIC Ρ DIETS. 1013
333. EFFECT OF ACTIVE VITAMIN D3 ON ENTEROCYTES AND FATTY ACID BINDING SUBSTANCE IN MICROSOMAL FRACTION OF INTESTINAL MUCOSA OF RATS. 1015
334. VITAMIN D THERAPY IN RENAL FAILURE - CHALLENGES AND PROBLEMS FOR THE FUTURE 1017
335. SYNTHESIS OF 24R,25-DIHYDROXYVITAMIN D3 FROM VITAMIN D2 AND STUDY ON INCLUSION COMPLEXES OF VITAMIN D DERIVATIVES WITH β-CYCLODEXTRIN 1021
336. AUTHOR INDEX 1025
337. KEY WORD INDEX 1033
338. CELL LINE INDEX 1067
339. VITAMIN D WORKSHOP ZOO 1069
340. Summary of the Dates and Locations of the Seven Vitamin D Workshops 1071
341. Vitamin D Workshop Logo 1072
342. 1073-1076 1073