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Biotechnological applications extremophiles: the golden epoch ahead

  • Bedaprana Roy , Debapriya Maitra , Rajeshwari Podder , Jaydip Ghosh and Arup Kumar Mitra
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Extremophiles
This chapter is in the book Extremophiles

Abstract

Extreme environments act as habitats that nurture a number of magnificent organisms that are tolerant to such harsh environments. These environments include areas with extreme temperatures, pH, salinity, pressure, and heavy metal concentrations. Biological and chemical processes encounter numerous such stressed conditions, control of which makes these processes delicate, prolonged, and expensive. For example, enzymes and proteins of the biological systems that are the main tools of any biochemical reaction and remain functional only at specific conditions lose their activity when minutely violated. The maintenance of these optimum or moderate conditions, also termed as mesophilic conditions in an ongoing reaction, requires huge efforts and expenses by scientists, all over. Therefore, enzymes and other products from extremophiles can act as a perfect alternative, reducing the efforts of procedure optimization to mesophilic conditions. The sole reason is that organisms that thrive in extremes are capable of producing enzymes and other useful products required in any biotechnological process, which can survive and remain active throughout the extremities reached during the ongoing reactions. In the field of agriculture, use of extremophiles can allow sustainable agriculture under all conditions and stresses that may occur in an agricultural field. Similarly, molecular biological tools such as PCR (polymerase chain reaction) require thermostable DNA polymerases that can be obtained from extremophiles. Therapeutic enzymes such as asparaginase, used for treatment of leukemia, can also be obtained from extremophiles that would remain stable inside the body and maintain its activity. Thus, use of extremophiles in all the aforementioned fields will be the future of biotechnology.

Abstract

Extreme environments act as habitats that nurture a number of magnificent organisms that are tolerant to such harsh environments. These environments include areas with extreme temperatures, pH, salinity, pressure, and heavy metal concentrations. Biological and chemical processes encounter numerous such stressed conditions, control of which makes these processes delicate, prolonged, and expensive. For example, enzymes and proteins of the biological systems that are the main tools of any biochemical reaction and remain functional only at specific conditions lose their activity when minutely violated. The maintenance of these optimum or moderate conditions, also termed as mesophilic conditions in an ongoing reaction, requires huge efforts and expenses by scientists, all over. Therefore, enzymes and other products from extremophiles can act as a perfect alternative, reducing the efforts of procedure optimization to mesophilic conditions. The sole reason is that organisms that thrive in extremes are capable of producing enzymes and other useful products required in any biotechnological process, which can survive and remain active throughout the extremities reached during the ongoing reactions. In the field of agriculture, use of extremophiles can allow sustainable agriculture under all conditions and stresses that may occur in an agricultural field. Similarly, molecular biological tools such as PCR (polymerase chain reaction) require thermostable DNA polymerases that can be obtained from extremophiles. Therapeutic enzymes such as asparaginase, used for treatment of leukemia, can also be obtained from extremophiles that would remain stable inside the body and maintain its activity. Thus, use of extremophiles in all the aforementioned fields will be the future of biotechnology.

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