14 Experimental observations on perinatal programming in offspring of diabetic mothers

Kapitel in diesem Buch

1. Frontmatter I
2. Contents V
3. Foreword XI
4. Abbreviations XIII
5. 1 The past and future of perinatal medicine 1
6. 2 Perinatal brain programming and functional teratology 5
7. 3 Experimental models of low birth weight – insight into the developmental programming of metabolic health, aging and immune function 11
8. 4 Cardiovascular consequences of IUGR: Experimental aspects 27
9. 5 Fetal programming of endocrine function in IUGR offspring depends on the cause of low birth weight: Evidence from animal models and the human FIPS-study 41
10. 6 Intrauterine corticosteroids for lung maturation: Observations of HPA axis function and cardiac autonomic balance in the neonate 51
11. 7 Feast or Famine: In the fast lane to puberty 59
12. 8 Early life origins of diabetes and obesity: General aspects and the thin – fat baby paradigm 69
13. 9 The outcome in offspring of obese mothers: Clinical and experimental aspects 83
14. 10 Short and long term effects of gestational obesity : Clinical observations 97
15. 11 Emerging role of neuroendocrine programming in obesity 107
16. 12 Genetic influences on the long-term effects of the perinatal environment on energy homeostasis and offspring obesity 129
17. 13 Perinatal programming in offspring of diabetic mothers: Clinical data 141
18. 14 Experimental observations on perinatal programming in offspring of diabetic mothers 153
19. 15 Prenatal infections and long-term mental outcome: Modeling schizophrenia-related dysfunctions using the prenatal Polyl:C model in mice 171
20. 16 Prenatal programming of cognition and emotion in humans: From birth to age 20 199
21. 17 Perinatal programming of allergy 207
22. 18 Perinatal origin of testicular germ cell cancer: Possible involvement of developmental reprogramming 219
23. 19 Epigenetic adaptation during early life 229
24. 20 Toward a unifying concept on perinatal programming: Vegetative imprinting by environment-dependent biocybernetogenesis 243
25. Author index 283
26. Index 287