Zum Hauptinhalt springen
Kapitel
Lizenziert
Nicht lizenziert Erfordert eine Authentifizierung

Chapter 15 Phytochemicals in drug discovery

  • und
Veröffentlichen auch Sie bei De Gruyter Brill
So veröffentlichen Sie bei uns
Phytochemicals in Medicinal Plants
Ein Kapitel aus dem Buch Phytochemicals in Medicinal Plants

Abstract

Here, we summarize phytochemicals, their health benefits, pharmacokinetics and pharmacodynamic characteristics, toxicity, and their application in the development of lead compounds and related drug analogs. Natural products and their structural analogues have significant contributions to pharmacotherapy, especially for the treatment of cancer, malaria, diabetes, and infectious diseases. Drug discovery employing phytochemicals obtained from different plant sources is the basis of new drug discovery and lead compound development. The process of drug discovery involves the identification, isolation, and purification of phytochemicals from the selected plant species, biochemical characterization, and pharmacological investigation followed by preclinical and clinical trials. Drug discovery also requires bioinformatics computational tools and structure elucidation by cutting-edge analytical techniques such as high-performance liquid chromatography, gas chromatography, and mass spectrometry. The phytochemicals sometimes require modification in the native structure for the enhancement of biological activity and stability. Consequently, lead identification and new drug discovery is an important toolbox for tackling antimicrobial resistance. At present, phytochemicals are the main pillar in new drug discovery and the pharmaceutical industry revolution. Therefore, new opportunities would be expected in the new drug discovery using phytochemicals in near future.

Abstract

Here, we summarize phytochemicals, their health benefits, pharmacokinetics and pharmacodynamic characteristics, toxicity, and their application in the development of lead compounds and related drug analogs. Natural products and their structural analogues have significant contributions to pharmacotherapy, especially for the treatment of cancer, malaria, diabetes, and infectious diseases. Drug discovery employing phytochemicals obtained from different plant sources is the basis of new drug discovery and lead compound development. The process of drug discovery involves the identification, isolation, and purification of phytochemicals from the selected plant species, biochemical characterization, and pharmacological investigation followed by preclinical and clinical trials. Drug discovery also requires bioinformatics computational tools and structure elucidation by cutting-edge analytical techniques such as high-performance liquid chromatography, gas chromatography, and mass spectrometry. The phytochemicals sometimes require modification in the native structure for the enhancement of biological activity and stability. Consequently, lead identification and new drug discovery is an important toolbox for tackling antimicrobial resistance. At present, phytochemicals are the main pillar in new drug discovery and the pharmaceutical industry revolution. Therefore, new opportunities would be expected in the new drug discovery using phytochemicals in near future.

Kapitel in diesem Buch

  1. Frontmatter I
  2. Preface V
  3. Contents VII
  4. About the editors XI
  5. List of contributors XIII
  6. Chapter 1 Habitat and distribution of medicinal plants 1
  7. Chapter 2 Threats and conservation of the medicinal plants 27
  8. Chapter 3 Culture, tradition, and indigenous practices on medicinal plants 53
  9. Chapter 4 Plants alkaloids and flavonoids: biosynthesis, classification, and medicinal uses 87
  10. Chapter 5 Terpenoids, steroids, and phenolic compounds of medicinal plants 105
  11. Chapter 6 Characterization techniques used for the analysis of phytochemical constituents 131
  12. Chapter 7 Medicinal bioactivity: anti-cancerous and anti-HIV activity of medicinal plants 153
  13. Chapter 8 Anti-cancerous and anti-HIV activity of medicinal plants 185
  14. Chapter 9 Antimicrobial, anti-inflammatory, and wound-healing activities of medicinal plants 205
  15. Chapter 10 Antioxidant activity of medicinal plants 227
  16. Chapter 11 Antidiabetic activity of selected Indian medicinal plants 247
  17. Chapter 12 Anti-coronavirus and antiviral activity of medicinal plants 269
  18. Chapter 13 Nanomaterials synthesis from medicinal plant extract 291
  19. Chapter 14 Bioactivity of nanoparticles synthesized from medicinal plants 315
  20. Chapter 15 Phytochemicals in drug discovery 331
  21. Chapter 16 Extraction and production of drugs from plant 347
  22. Index 369
https://doi.org/10.1515/9783110791891-015

Kapitel in diesem Buch

  1. Frontmatter I
  2. Preface V
  3. Contents VII
  4. About the editors XI
  5. List of contributors XIII
  6. Chapter 1 Habitat and distribution of medicinal plants 1
  7. Chapter 2 Threats and conservation of the medicinal plants 27
  8. Chapter 3 Culture, tradition, and indigenous practices on medicinal plants 53
  9. Chapter 4 Plants alkaloids and flavonoids: biosynthesis, classification, and medicinal uses 87
  10. Chapter 5 Terpenoids, steroids, and phenolic compounds of medicinal plants 105
  11. Chapter 6 Characterization techniques used for the analysis of phytochemical constituents 131
  12. Chapter 7 Medicinal bioactivity: anti-cancerous and anti-HIV activity of medicinal plants 153
  13. Chapter 8 Anti-cancerous and anti-HIV activity of medicinal plants 185
  14. Chapter 9 Antimicrobial, anti-inflammatory, and wound-healing activities of medicinal plants 205
  15. Chapter 10 Antioxidant activity of medicinal plants 227
  16. Chapter 11 Antidiabetic activity of selected Indian medicinal plants 247
  17. Chapter 12 Anti-coronavirus and antiviral activity of medicinal plants 269
  18. Chapter 13 Nanomaterials synthesis from medicinal plant extract 291
  19. Chapter 14 Bioactivity of nanoparticles synthesized from medicinal plants 315
  20. Chapter 15 Phytochemicals in drug discovery 331
  21. Chapter 16 Extraction and production of drugs from plant 347
  22. Index 369
Heruntergeladen am 16.5.2026 von https://www.degruyterbrill.com/document/doi/10.1515/9783110791891-015/html?lang=de
Button zum nach oben scrollen