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Two Rare Hydroazulene-type Sesquiterpenes from the Roots of Aristolochia yunnanensis
-
Zhuo Du
,
Ji-Ping Zhang
Published/Copyright:
June 2, 2014
Two new sesquiterpenes, named aristoyunnolin I (1) and J (2), together with eight known compounds (3 - 10) were isolated from the roots of Aristolochia yunnanensis. Compounds 1 and 2 feature a rare hydroazulene-type sesquiterpene skeleton and represent the third and fourth examples of this kind found in nature. The structures were determined from spectroscopic data, and the absolute configurations of 1 - 3 were assigned by comparing experimental with simulated electronic circular dichroism (ECD) spectra. Compounds 1, 2, 6 - 10 were isolated from this plant for the first time. The cytotoxic activities of 1 - 10 were evaluated against P-388 and A-549 cell lines. Only compounds 4 and 5 showed moderate activity with IC50 values ranging from 12.0 to 18.2 μM.
Graphical Abstract
Two Rare Hydroazulene-type Sesquiterpenes from the Roots of Aristolochia yunnanensis
Keywords: Aristolochia yunnanensis; Aristoyunnolin; Hydroazulene-type Sesquiterpene; Cytotoxic Activities
Received: 2014-3-6
Published Online: 2014-6-2
Published in Print: 2014-6-1
© 1946 – 2014: Verlag der Zeitschrift für Naturforschung
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Keywords for this article
Aristolochia yunnanensis;
Aristoyunnolin;
Hydroazulene-type Sesquiterpene;
Cytotoxic Activities
Articles in the same Issue
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- Strukturen von polaren Magnesiumorganylen: Synthese und Struktur von Basen-Addukten des Bis(pentamethylcyclopentadienyl)magnesiums
- The Mixed-valent Mercury(I/II) Compounds Hg3(HAsO4)2 and Hg6As2O10
- New Intermetallic Zinc Compounds with Ordering Variants of the KHg2 and LT-SrZn5 Type
- Effects of Metal Ions and N-Donor Ligands with Different Coordination Characters on the Construction of d10 Metal-organic Complexes with Selective Photocatalytic Activities
- Synthesis and Characterization of Novel Re(BIAN)(CO)3Cl Derivatives Including the First Example of a Water-soluble Tricarbonyl Rhenium(I) Complex with Bis(imino)acenaphthene Ligands
- Hydrothermal Synthesis and Crystal Structure of a One-dimensional Cobalt (II) Coordination Polymer with Two Organic Ligands
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- Spiroalkaloids and Coumarins from the Stem Bark of Pauridiantha callicarpoides
