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Controlled release of ofloxacin from gelatin blended with cloisite 30B

  • Debasish Sahoo and Padma Lochan Nayak
Published/Copyright: May 15, 2013
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International Journal of Materials Research
From the journal International Journal of Materials Research Volume 103 Issue 11

Abstract

Gelatin–Cloisite 30B (C 30B) hybrid nano-composites were prepared by blending gelatin with cloisite 30B in aqueous solution. The nano-composites were characterized by using FTIR, SEM and XRD analysis. From the FTIR spectra the various groups present in the gelatin blend were monitored. The homogeneity, morphology and crystallinity of the blends were ascertained from SEM and XRD data, respectively. The results indicate that an intercalated or partially exfoliated nano-composite can be achieved, and the properties of the composite are significantly improved. The drug release kinetics was investigated using ofloxacin as the drug. The kinetics of the drug delivery system was systematically studied. Drug release kinetics was analyzed by plotting the cumulative release data vs. time by fitting to an exponential equation which indicates the non-Fickian type of kinetics. The drug release was investigated at different pH medium and it was found that the drug release depends upon the pH medium as well as the nature of the matrix.

Keywords: Gelatin; Cloisite 30B; Ofloxacin; Controlled drug delivery; Kinetics
∗ Correspondence address Debasish Sahoo, P. L. Nayak Research Foundation, Neelachal Bhavan, Bidyadharpur, Cuttak, Odisha 753004, India, Tel.: +91-9090463263, E-mail:

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Received: 2011-5-17
Accepted: 2012-2-14
Published Online: 2013-05-15
Published in Print: 2012-11-01

© 2012, Carl Hanser Verlag, München

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https://doi.org/10.3139/146.110766
Keywords for this article
Gelatin; Cloisite 30B; Ofloxacin; Controlled drug delivery; Kinetics

Articles in the same Issue

  1. Contents
  2. Contents
  3. Award/Preisverleihung
  4. The Werner-Köster-Preis 2011
  5. Original Contributions
  6. Ostwald ripening in Al–Li alloys: A test of theory
  7. The Mg–C phase equilibria and their thermodynamic basis
  8. Experimental and thermodynamic study of nickel (30 wt.%Cr) – based alloys containing between 2.5 and 5.0 wt.% carbon
  9. Thermodynamic description of the system Cu–Sn–P experimental and numerical investigation
  10. Severe tempering of bainite generated at low transformation temperatures
  11. A comparative study of microstructure, compressive, and fracture properties of Ti3Al-based intermetallics produced via powder metallurgy, and melting and casting processes
  12. Rod-like structure and microhardness during directional solidification of Sn-1wt.%Cu eutectic alloy
  13. Properties of Si3N4/SiC composites produced via spark plasma sintering
  14. Formation of Al67Cu23Fe10 quasicrystals by microwave heating
  15. Magnetoelectric characteristics of cobalt-iron alloy–lead zirconate titanate bilayer planar structures
  16. On the texture and grain growth in hot-deformed and annealed WE54 alloy
  17. Numerical study of equal-channel angular pressing based on the element-free Galerkin method
  18. Dynamic behavior of staggered triangular honeycomb cores under in-plane crushing loadings
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  24. Horst Vehoff 65 years
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