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Synthesis, molecular characterisation, and in vivo study of platinum(IV) coordination compounds against B16 mouse melanoma tumours

  • Iwona Łakomska EMAIL logo , Anna Kaźnica , Romana Joachimiak , Andrzej Marszałek , Jerzy Sitkowski , Lech Kozerski and Tomasz Drewa
Published/Copyright: March 16, 2011
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Abstract

A novel platinum(IV) coordination compound with 6-mercaptopurine (6-Hmp) has been synthesised and characterised by IR and NMR spectroscopy. Spectroscopic parameters indicate the presence of two chelate (S-6, N-7) monodeprotonated ligands and two chloride ions in the coordination sphere of [PtCl2(6-mp)2] · H2O (I). Two Pt(IV) coordination compounds, [PtCl2(6-mp)2] · H2O (I) and [PtCl4(dbtp)2] (II), were used in the in vivo test against B16 mouse melanoma tumours. Cytotoxic activity of compound II against the tumour cells was found to be high (LC10 = 2.6 μM, LC50 = 17.0 μM, LC90 = 58.0 μM) compared to that of cisplatin.

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Published Online: 2011-3-16
Published in Print: 2011-6-1

© 2011 Institute of Chemistry, Slovak Academy of Sciences

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