Potential in vivo generator for alpha-particle therapy with 212Bi: Presentation of a system to minimize escape of daughter nuclide after decay of 212Pb to 212Bi
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G. Henriksen
Abstract
Radiopharmaceuticals based on 212Pb (t1/2=10.6 h) are of interest for use as an in vivo generator of α-particle emitting 212Bi (t1/2=60.6 min). Sterically stabilized liposomes were evaluated as carriers of 212Pb/212Bi radionuclides in the reported study. 212Pb/212Bi-containing vesicles were prepared by ionophore mediated loading of 212Pb into preformed liposomes. The liposomal uptake of 212Pb with or without various concentrations of lead carrier was investigated. The retention of 212Pb and 212Bi in liposomes incubated in serum was studied. Conditions were found yielding a high and rapid uptake of 212Pb in liposomes. 90±2% of 212Pb was incorporated after 30 min. The retention of radionuclides was high, 95% of 212Pb and 212Bi were retained in liposomes after incubating for 20 h at 37°C in serum. The results from the present work indicate that an effective retention of 212Bi after the β--decay of 212Pb is achievable. This technology could be the basis of α-emitting radiopharmaceuticals built upon 212Pb.
© 2003 Oldenbourg Wissenschaftsverlag GmbH
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Articles in the same Issue
- Some rules to improve the energy resolution in alpha liquid scintillation with beta rejection
- Confidence intervals for experiments with background and small numbers of events
- Solubility product of Pu(VI) hydrous oxide
- Precipitation of crystalline neptunium dioxide from near-neutral aqueous solution
- Stability of U(VI) solid phases in the U(VI)-Ca2+-SiO2-OH system
- Synergistic extraction of Th(IV) by 2-hydroxy-1-naphthaldehyde thiosemicarbazone and neutral donors
- Production of 55Co via the 54Fe(d,n)-process and excitation functions of 54Fe(d,t)53Fe and 54Fe(d,α)52mMn reactions from threshold up to 13.8 MeV
- Potential in vivo generator for alpha-particle therapy with 212Bi: Presentation of a system to minimize escape of daughter nuclide after decay of 212Pb to 212Bi
- In vitro study of the interaction between neptunium ions and aposerumtransferrin by absorption spectrophotometry and ultrafiltration: the case of Np(V)
