Abstract
Success in treating patients with atypical parkinsonism remains exceedingly low. It is particularly important for both neurologists and general practicians to have a guideline in the actual possible cure options. This study reviews the limited available literature reporting treatment trials about treatment in parkinsonism. Various therapeutical approaches have been tried with rasagiline, immunoglobulin, autologous mesenchymal stem cells, davunetide, lithium, and tideglusib. Recently, the transdermal rotigotine has been proposed for the treatment of atypical parkinsonism, as well as deep brain stimulation (DBS) of the peduncolopontine nucleus alone or combined with globus pallidus internus stimulation. The outcomes reviewed here highlight the need for the development of randomized, placebo-controlled trials to validate outcomes about rotigotine, DBS, and all other new therapies directed at altering the underlying biological mechanisms involved in the disease process.
References
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©2015 by De Gruyter
Articles in the same Issue
- Frontmatter
- On the role of the extracellular space on the holistic behavior of the brain
- Temporal phases of long-term potentiation (LTP): myth or fact?
- Are there treatments for atypical parkinsonism? An update on actual options
- Clinical experimental stress studies: methods and assessment
- Genetic aspects of intervertebral disc degeneration
- Corrigendum
- Corrigendum to: Genetic associations of leukoaraiosis indicate pathophysiological mechanisms in white matter lesions etiology
Articles in the same Issue
- Frontmatter
- On the role of the extracellular space on the holistic behavior of the brain
- Temporal phases of long-term potentiation (LTP): myth or fact?
- Are there treatments for atypical parkinsonism? An update on actual options
- Clinical experimental stress studies: methods and assessment
- Genetic aspects of intervertebral disc degeneration
- Corrigendum
- Corrigendum to: Genetic associations of leukoaraiosis indicate pathophysiological mechanisms in white matter lesions etiology