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A novel method for evaluating the depletion of veterinary pharmaceuticals using radioisotopes

  • Yousef Fazaeli ORCID logo EMAIL logo , Gholamreza Shahhoseini , Alireza Neisi , James Jacob Sasanya , Parviz Ashtari and Shahzad Feizi
Published/Copyright: February 16, 2024
Radiochimica Acta
From the journal Radiochimica Acta Volume 112 Issue 4

Abstract

Antimicrobial resistance (AMR) as one of the world’s most pressing public health problems needs immediate attention, because it has the ability to affect the human healthcare, agriculture, and veterinary industries. Despite warnings about overuse and their implications, antimicrobials are overprescribed worldwide for humans and animals, which leads to the promotion of resistant microorganisms such as bacteria. Food is a medium for exposure to or transfer of residues of the drugs and can contribute to the burden of the pharmaceuticals associated with development of AMR. Studying on residues of veterinary drugs in foods is essential in the fight against AMR. Herein, we introduce a new method for visualizing the residues of a veterinary drug in animal matrices using radionuclides, called “Depletion Imaging”. Amoxicillin was chosen to be the first antimicrobial for this study. The drug was labeled with [62Zn/65Zn] ZnCl2. Radiolabelled amoxicillin and non-labeled amoxicillin were administrated to rainbow trout fish simultaneously. To enable visualization of the remaining residues of amoxicillin in fish, In-vivo positron emission tomography (PET) imaging was done at different intervals from 30 min to 21 days after administration. Evaluation of the amount of radiolabelled amoxicillin in fish was done using a high purity germanium (HPGe) nuclear detector, and enzyme linked immunosorbent assay (ELISA) technique was used for the non-labeled drug. In this study, a comprehensive method for in-house production of zinc radioisotopes was also included. The results showed that depletion imaging and biodistribution study based on gamma spectroscopy of radionuclides in tissues, is a precise method for accurate understanding of the drug’s distribution, metabolic and excretory profile.

Keywords: depletion imaging; radiolabelled amoxicillin; zinc radionuclides; PET imaging; drug residue
Corresponding author: Yousef Fazaeli, Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Moazzen Blvd., Rajaeeshahr, P.O. Box 31485-498, Karaj, Iran, E-mail:

Acknowledgment

This study was supported in part by the joint FAO/IAEA division (Centre) of Nuclear Techniques in Food & Agriculture, and Coordinated Research Project (CRP): D52043 entitled: “Depletion of Veterinary Pharmaceuticals and Radiometric Analysis of their Residues in Animal Matrices”.

  1. Research ethics: The local Institutional Review Board deemed the study exempt from review. The animal experiments were performed under guidelines on the use of living animals in scientific investigations.

  2. Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: The authors state no conflict of interest.

  4. Research funding: None declared.

  5. Data availability: The raw data can be obtained on request from the corresponding author.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/ract-2023-0249).

Received: 2023-11-10
Accepted: 2024-01-28
Published Online: 2024-02-16
Published in Print: 2024-04-25

© 2024 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/ract-2023-0249
Keywords for this article
depletion imaging; radiolabelled amoxicillin; zinc radionuclides; PET imaging; drug residue

Articles in the same Issue

  1. Frontmatter
  2. Original Papers
  3. Reverse phase liquid chromatographic method for the measurement of uranium in process stream solutions from uranium extraction facility
  4. An LSC approach for tritium determination in gaseous mixtures optimized with respect to handling, reaction parameters and miniaturization towards microfluidic analysis
  5. Application of thin boron deposit by electrophoresis as neutron detectors
  6. Development of [64Cu]Cu-BPAMD for PET imaging of bone metastases
  7. Investigation of the dose-response linearity of guar gum for gamma-ray dosimetry at radiation processing levels using Raman spectroscopy
  8. A novel method for evaluating the depletion of veterinary pharmaceuticals using radioisotopes
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  10. Obituary
  11. In Memoriam: Jens Volker Kratz (1944–2024)
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