Xanthoangelol, geranilated chalcone compound, isolation from pudau leaves (Artocarpus kemando Miq.) as antibacterial and anticancer
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Tati Suhartati
,
Novita Andriyani
Abstract
From the leaves of Artocarpus kemando Miq, locally known as pudau plant, a flavonoid has been isolated and identified. The compound was then tested as antibacterial agent against Bacillus subtillis and Escherichia coli. The first step of isolation was extraction by maceration using methanol as solvent, and then followed by fractionation using partition treatment and vacuum liquid chromatography. Finally, the compound was purified using column chromatography method. The purity of the compound was evaluated using thin layer chromatography and melting point measurement, and the compound was subsequently characterized using UV–Vis, IR, and NMR spectroscopy. A total of 66.2 mg of the compound was obtained, in the form of yellow needle crystals with a melting point of 142.8–144 °C, which is a compound of geranylated chalcone, xanthoangelol. Xanthoangelol was the first chalcone compound isolated from A. kemando. Antibacterial tests were carried out at varied doses of 0.5; 0.4; and 0.3 mg/disk, and revealed that the compound exhibits high inhibitory power against B. subtillis, but has no activity against E. coli. The anticancer activity of xanthoangelol on MCF-7 cells indicated that the compound has an IC50 value of 7.79 μg/mL, suggesting that the compound possesses an active cytotoxic activity.
Funding source: Kementerian Pendidikan dan Kebudayaan
Award Identifier / Grant number: 027/E5/PG.02.00/PT/2022 dated 16 March 2022 and 21
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Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: The author would like to thank the Ministry of Education, Culture, Research and Technology, for funding support in the form of Basic Research, fiscal year 2022 with contract number 027/E5/PG.02.00/PT/2022 dated 16 March 2022 and 2143/UN26.21/PN/2022 29 April, 2022.
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Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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Articles in the same Issue
- Frontmatter
- Reviews
- Modern analytical approach in biopolymer characterization
- Development of nanocellulose fiber reinforced starch biopolymer composites: a review
- Recent developments in sago starch thermoplastic bio-composites
- Mechanical degradation of sugar palm crystalline nanocellulose reinforced thermoplastic sugar palm starch (TPS)/poly (lactic acid) (PLA) blend bionanocomposites in aqueous environments
- Computational design of the novel building blocks for the metal-organic frameworks based on the organic ligand protected Cu4 cluster
- Highly functional nanocellulose-reinforced thermoplastic starch-based nanocomposites
- Spectral peak areas do not vary according to spectral averaging scheme used in functional MRS experiments at 3 T with interleaved visual stimulation
- Triterpenoids of antibacterial extracts from the leaves of Bersama abyssinica Fresen (Francoaceae)
- Immediate effects of atrazine application on soil organic carbon and selected macronutrients and amelioration by sawdust biochar pretreatment
- Process configuration of combined ozonolysis and anaerobic digestion for wastewater treatment
- Concentration levels and risk assessment of organochlorine and organophosphate pesticide residue in selected cereals and legumes sold in Anambra State, south-eastern Nigeria
- XRD and cytotoxicity assay of submitted nanomaterial industrial samples in the Philippines
- Comparative study of the photocatalytic degradation of tetracycline under visible light irradiation using Bi24O31Br11-anchored carbonaceous and silicates catalyst support
- Xanthoangelol, geranilated chalcone compound, isolation from pudau leaves (Artocarpus kemando Miq.) as antibacterial and anticancer
- Barley thermoplastic starch nanocomposite films reinforced with nanocellulose
- Integration of chemo- and bio-catalysis to intensify bioprocesses
- Fabrication of starch-based packaging materials
- Potato thermoplastic starch nanocomposite films reinforced with nanocellulose
- Review on sago thermoplastic starch composite films reinforced with nanocellulose
- Wheat thermoplastic starch composite films reinforced with nanocellulose
- Synergistic effect in bimetallic gold catalysts: recent trends and prospects
- Simultaneous removal of methylene blue, copper Cu(II), and cadmium Cd(II) from synthetic wastewater using fennel-based adsorbents
- The investigation of the physical properties of an electrical porcelain insulator manufactured from locally sourced materials
- Concentration evaluation and risk assessment of pesticide residues in selected vegetables sold in major markets of Port Harcourt South-South Nigeria
- Detection of iodine in aqueous extract of plants through modified Mohr’s method
- Exploration of bioactive compounds from Mangifera indica (Mango) as probable inhibitors of thymidylate synthase and nuclear factor kappa-B (NF-Κb) in colorectal cancer management
- A new sphingoid derivative from Acacia hockii De Wild (Fabaceae) with antimicrobial and insecticidal properties
- Protection of wood against bio-attack and research of new effective and environmental friendly fungicides
- Computational investigation of Arbutus serratifolia Salisb molecules as new potential SARS-CoV-2 inhibitors
- Exploring the solvation of water molecules around radioactive elements in nuclear waste water treatment
Articles in the same Issue
- Frontmatter
- Reviews
- Modern analytical approach in biopolymer characterization
- Development of nanocellulose fiber reinforced starch biopolymer composites: a review
- Recent developments in sago starch thermoplastic bio-composites
- Mechanical degradation of sugar palm crystalline nanocellulose reinforced thermoplastic sugar palm starch (TPS)/poly (lactic acid) (PLA) blend bionanocomposites in aqueous environments
- Computational design of the novel building blocks for the metal-organic frameworks based on the organic ligand protected Cu4 cluster
- Highly functional nanocellulose-reinforced thermoplastic starch-based nanocomposites
- Spectral peak areas do not vary according to spectral averaging scheme used in functional MRS experiments at 3 T with interleaved visual stimulation
- Triterpenoids of antibacterial extracts from the leaves of Bersama abyssinica Fresen (Francoaceae)
- Immediate effects of atrazine application on soil organic carbon and selected macronutrients and amelioration by sawdust biochar pretreatment
- Process configuration of combined ozonolysis and anaerobic digestion for wastewater treatment
- Concentration levels and risk assessment of organochlorine and organophosphate pesticide residue in selected cereals and legumes sold in Anambra State, south-eastern Nigeria
- XRD and cytotoxicity assay of submitted nanomaterial industrial samples in the Philippines
- Comparative study of the photocatalytic degradation of tetracycline under visible light irradiation using Bi24O31Br11-anchored carbonaceous and silicates catalyst support
- Xanthoangelol, geranilated chalcone compound, isolation from pudau leaves (Artocarpus kemando Miq.) as antibacterial and anticancer
- Barley thermoplastic starch nanocomposite films reinforced with nanocellulose
- Integration of chemo- and bio-catalysis to intensify bioprocesses
- Fabrication of starch-based packaging materials
- Potato thermoplastic starch nanocomposite films reinforced with nanocellulose
- Review on sago thermoplastic starch composite films reinforced with nanocellulose
- Wheat thermoplastic starch composite films reinforced with nanocellulose
- Synergistic effect in bimetallic gold catalysts: recent trends and prospects
- Simultaneous removal of methylene blue, copper Cu(II), and cadmium Cd(II) from synthetic wastewater using fennel-based adsorbents
- The investigation of the physical properties of an electrical porcelain insulator manufactured from locally sourced materials
- Concentration evaluation and risk assessment of pesticide residues in selected vegetables sold in major markets of Port Harcourt South-South Nigeria
- Detection of iodine in aqueous extract of plants through modified Mohr’s method
- Exploration of bioactive compounds from Mangifera indica (Mango) as probable inhibitors of thymidylate synthase and nuclear factor kappa-B (NF-Κb) in colorectal cancer management
- A new sphingoid derivative from Acacia hockii De Wild (Fabaceae) with antimicrobial and insecticidal properties
- Protection of wood against bio-attack and research of new effective and environmental friendly fungicides
- Computational investigation of Arbutus serratifolia Salisb molecules as new potential SARS-CoV-2 inhibitors
- Exploring the solvation of water molecules around radioactive elements in nuclear waste water treatment
