A novel double-layer nanofiber with gelatin–kaolin/polyvinylpyrrolidone–thrombin for rapid homeostasis
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Jin Wang
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Yuan Liu
Abstract
In this study, a novel nanofiber material with gelatin/kaolin was developed with electrostatic spinning technology for rapid hemostasis. The performance of the materials was evaluated through physicochemical characterization, cytological experiments, and assessments of hemolysis and coagulation. The coagulation time of our material was significantly reduced to 60 s by incorporating nanokaolin. Furthermore, when thrombin was introduced, superfast hemostatic materials were created, resulting in coagulation within 5 s. Moreover, the material has good biocompatibility. The current material exhibits exceptional hemostatic properties and enhances wound healing and will be an effective hemostatic excipient in the future.
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Research ethics: Not applicable.
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Informed consent: Not applicable.
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Author contributions: Jin Wang, Yuan Liu, Yanchen Gao, and Xing Zhang conceived and designed the study. Yuan Liu interpreted the data. Jin Wang, Yuan Liu, Yafang Liu, Yanchen Gao, and Xing Zhang prepared the manuscript. All the authors read and approved the final version of the manuscript for publication.
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Use of Large Language Models, AI and Machine Learning Tools: None.
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Conflict of interest: The authors declare that they have no competing financial interests.
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Research funding: This work was supported by the Youth Program of Guangdong Provincial Hospital of Chinese Medicine (YN2023QN02).
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Data availability: Data available on request from the authors.
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© 2025 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Material Properties
- N-aminophthalimide as a novel UV-stabilizer to promote physico-mechanical properties of high-density polyethylene (HDPE)
- A novel double-layer nanofiber with gelatin–kaolin/polyvinylpyrrolidone–thrombin for rapid homeostasis
- Preparation and Assembly
- Preparation of ER/NR foamed composites with adjustable shape memory and oil adsorption properties
- Emerging trends in cryogelation: key factors influencing cryotropic gelation processes
- Preparation of chitosan/nano-copper sulfide/carrageenan bilayer film and its application in strawberry preservation
- A feasible chemo preventive approach involves the use of zinc-coated curcumin with a carrageenan matrix for improved stability, solubility, and bioavailability
- Engineering and Processing
- Controlling surface morphology of spin coated epoxy composites using the Marangoni instability
Articles in the same Issue
- Frontmatter
- Material Properties
- N-aminophthalimide as a novel UV-stabilizer to promote physico-mechanical properties of high-density polyethylene (HDPE)
- A novel double-layer nanofiber with gelatin–kaolin/polyvinylpyrrolidone–thrombin for rapid homeostasis
- Preparation and Assembly
- Preparation of ER/NR foamed composites with adjustable shape memory and oil adsorption properties
- Emerging trends in cryogelation: key factors influencing cryotropic gelation processes
- Preparation of chitosan/nano-copper sulfide/carrageenan bilayer film and its application in strawberry preservation
- A feasible chemo preventive approach involves the use of zinc-coated curcumin with a carrageenan matrix for improved stability, solubility, and bioavailability
- Engineering and Processing
- Controlling surface morphology of spin coated epoxy composites using the Marangoni instability
