Study on the preparation and drug release property of soybean selenoprotein/carboxymethyl chitosan composite hydrogel
-
Yong Hu
,
Xiao Y. Wu
Abstract
Soybean selenoprotein/carboxymethyl chitosan (SSP/CMCS) composite hydrogel obtained by the crosslinking of genipin was evaluated for caffeine release. The gelation process of the hydrogel was investigated by resonance Rayleigh scattering spectra and viscosity methods. The hydrogels presented a compact network structure, which was observed by positive fluorescence microscopy (PFM). The structural properties of the hydrogel were revealed by fluorescence and FT-IR. The swelling characteristic of the hydrogel and its application in the slow release of caffeine were also studied. These results indicate that there is obvious interaction between SSP and CMCS by the addition of genipin, and the CMCS/SSP solution experiences a significant sol-gel phase transition process upon polymerization. The swelling ratio and release of caffeine slow down obviously at pH 1.2. However, larger swelling and more drug release can be observed at pH 7.4. The experimental values of the empiric diffusional exponent show that the release profiles abide by the non-Fickian diffusion process under both investigated pH conditions. The hydrogel, which is pale transparent with light yellow color at room temperature, can be formulated to be a suitable carrier for site-specific drug delivery.
Acknowledgments
This research was supported by the Characteristic Innovation Project of Colleges and Universities in Guangdong (grant no. 2015KTSCX072) and the Innovation and Strong School Project of Guangdong Pharmaceutical University (grant no. 2015cxqx156).
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©2018 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
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- Steady shear and dynamic strain thickening of halloysite nanotubes and fumed silica shear thickening composite
- Diffusivity of solvents in semi-crystalline polyethylene using the Vrentas-Duda free-volume theory
- Toughening effect and mechanism of polyamide 12 and modified montmorillonite in polybenzoxazine resin
- The effects of cross-linked/uncross-linked electrospun fibrinogen/polycaprolactone nanofibers on the proliferation of normal human epidermal keratinocytes
- Frequency independent AC electrical conductivity and dielectric properties of polyaniline-based conductive thermosetting composite
- Preparation and assembly
- Study on the preparation and drug release property of soybean selenoprotein/carboxymethyl chitosan composite hydrogel
- Engineering and processing
- Interaction of nanofillers in injection-molded graphene/carbon nanotube reinforced PA66 hybrid nanocomposites
- Prediction of the yellowing of styrene-stat-acrylonitrile and acrylonitrile-butadiene-styrene during processing in an internal mixer
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Articles in the same Issue
- Frontmatter
- Material properties
- Steady shear and dynamic strain thickening of halloysite nanotubes and fumed silica shear thickening composite
- Diffusivity of solvents in semi-crystalline polyethylene using the Vrentas-Duda free-volume theory
- Toughening effect and mechanism of polyamide 12 and modified montmorillonite in polybenzoxazine resin
- The effects of cross-linked/uncross-linked electrospun fibrinogen/polycaprolactone nanofibers on the proliferation of normal human epidermal keratinocytes
- Frequency independent AC electrical conductivity and dielectric properties of polyaniline-based conductive thermosetting composite
- Preparation and assembly
- Study on the preparation and drug release property of soybean selenoprotein/carboxymethyl chitosan composite hydrogel
- Engineering and processing
- Interaction of nanofillers in injection-molded graphene/carbon nanotube reinforced PA66 hybrid nanocomposites
- Prediction of the yellowing of styrene-stat-acrylonitrile and acrylonitrile-butadiene-styrene during processing in an internal mixer
- Milling process optimization for the best surface coat adhesion of the rigid polyurethane foam
- A numerical analysis of calendering of Oldroyd 4-constant fluid
