The value of fibrinogen combined with D-dimer and neonatal weight in predicting postpartum hemorrhage in vaginal delivery
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Yanke Zou
,
Shuai Zeng
,
Changxiao Huang
Abstract
Objectives
The purpose of this study was to explore whether fibrinogen (Fib) can be used as a predictor of postpartum hemorrhage (PPH) in parturients with vaginal delivery, and the value of combining Fib with other indexes to predict postpartum hemorrhage in vaginal delivery.
Methods
A total of 207 parturients who delivered via vagina were divided into PPH group (n=102) and non-PPH group (n=105). The PPH group was further divided into mild PPH group and severe PPH group. The differences of Fib, platelet (PLT), mean platelet volume (MPV), platelet distribution width (PDW), D-dimer (D-D), hemoglobin (HGB) and neonatal weight (Nw) between the two groups were compared to explore the significance of these indexes in predicting PPH.
Results
Fib, PLT and PDW in PPH group were significantly lower than those in non-PPH group, while D-D and Nw in PPH group were significantly higher than those in non-PPH group. In the binary logistic regression model, we found that Fib, D-D and Nw were independently related to PPH. The risk of PPH increased by 9.87 times for every 1 g/L decrease in Fib. The cut-off value of Fib is 4.395 (sensitivity 0.705, specificity 0.922). The AUC value of PPH predicted by Fib combined with D-D and Nw was significantly higher than that of PPH predicted by Fib (p<0.05, 95 % CI 0.00313–0.0587).
Conclusions
Fib, D-D and Nw have good predictive value for PPH of vaginal delivery, among which Fib is the best. The combination of three indexes of Fib, D-D and Nw can predict PPH more systematically and comprehensively, and provide a basis for clinical prevention and treatment of PPH.
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Research ethics: The research related to human use has complied with all the relevant nationaregulations, institutional policies, and in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional Review Board or equivalent committee (Ethics Committee of Army Medical Center of PLA, No. 23-01(2020)).
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Informed consent: Not applicable.
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Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: The authors state no conflict of interest.
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Research funding: None declared.
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Data availability: The raw data can be obtained on request from the corresponding author.
References
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© 2024 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Review
- Outcome of fetal congenital pulmonary malformations: a systematic review and meta-analysis
- Original Articles – Obstetrics
- Reducing decisional conflict in decisions about prenatal genetic testing: the impact of a dyadic intervention at the start of prenatal care
- The value of fibrinogen combined with D-dimer and neonatal weight in predicting postpartum hemorrhage in vaginal delivery
- Current obstetric outcomes in Jamaican women with sickle hemoglobinopathy – a balance of risks for aspirin?
- Does delayed cord clamping result in higher maternal blood loss in primary cesarean sections? A retrospective comparative study
- Trends in antenatal corticosteroid administration: did our timing improve?
- A national survey on current practice of ultrasound in labor ward
- Understanding current antenatal Hepatitis C testing and care in maternity services in England
- Exploring the clinical utility of exome sequencing/Mono, Duo, Trio in prenatal testing: a retrospective study in a tertiary care centre in South India
- Original Articles – Fetus
- Fetoscopic laser coagulation for twin-to-twin transfusion syndrome: a comparison of flexible 1.0/1.2 mm fetoscopes with curved sheaths of 2.7/3.3 mm2 vs. 2 mm fetoscopic lens technique with sheaths of 6.6/11.3 mm2
- Value of fetal echocardiographic examination in pregnancies complicated by preterm premature rupture of membranes
- Bias in the prenatal lung measurements in fetal congenital diaphragmatic hernia with intrauterine growth restriction
- Original Articles – Neonates
- Chest radiographic thoracic areas and respiratory outcomes in infants with anterior abdominal wall defects
- Temporal effects of caffeine on intrapulmonary shunt in preterm ventilated infants
- Letter to the Editor
- HDlive Silhouette features of physiological midgut herniation
Articles in the same Issue
- Frontmatter
- Review
- Outcome of fetal congenital pulmonary malformations: a systematic review and meta-analysis
- Original Articles – Obstetrics
- Reducing decisional conflict in decisions about prenatal genetic testing: the impact of a dyadic intervention at the start of prenatal care
- The value of fibrinogen combined with D-dimer and neonatal weight in predicting postpartum hemorrhage in vaginal delivery
- Current obstetric outcomes in Jamaican women with sickle hemoglobinopathy – a balance of risks for aspirin?
- Does delayed cord clamping result in higher maternal blood loss in primary cesarean sections? A retrospective comparative study
- Trends in antenatal corticosteroid administration: did our timing improve?
- A national survey on current practice of ultrasound in labor ward
- Understanding current antenatal Hepatitis C testing and care in maternity services in England
- Exploring the clinical utility of exome sequencing/Mono, Duo, Trio in prenatal testing: a retrospective study in a tertiary care centre in South India
- Original Articles – Fetus
- Fetoscopic laser coagulation for twin-to-twin transfusion syndrome: a comparison of flexible 1.0/1.2 mm fetoscopes with curved sheaths of 2.7/3.3 mm2 vs. 2 mm fetoscopic lens technique with sheaths of 6.6/11.3 mm2
- Value of fetal echocardiographic examination in pregnancies complicated by preterm premature rupture of membranes
- Bias in the prenatal lung measurements in fetal congenital diaphragmatic hernia with intrauterine growth restriction
- Original Articles – Neonates
- Chest radiographic thoracic areas and respiratory outcomes in infants with anterior abdominal wall defects
- Temporal effects of caffeine on intrapulmonary shunt in preterm ventilated infants
- Letter to the Editor
- HDlive Silhouette features of physiological midgut herniation
