The use of atosiban prolongs pregnancy in patients treated with fetoscopic endotracheal occlusion (FETO)
-
Przemyslaw Kosinski
,
Katarzyna Luterek
and
Miroslaw Wielgos
Abstract
Objective
To evaluate the impact of atosiban as a tocolytic agent in patients treated with the fetoscopic endotracheal occlusion (FETO) procedure due to congenital diaphragmatic hernia (CDH). As premature birth after fetoscopy remains a serious concern, an effort to reduce prematurity is required.
Methods
A total of 43 patients with severe CDH treated with FETO were enrolled in this study. The study group consisted of 22 patients who received atosiban during the FETO procedure and a control group of 21 patients who did not receive atosiban during the FETO procedure. Demographic data, gestational age (GA) at delivery, cervical length and GA at premature rupture of membranes (PROM) were evaluated.
Results
The GA at delivery was significantly different between the two groups studied. The median GA at delivery was 32.6 and 34.5 weeks in the no-atosiban vs. atosiban groups, respectively (P = 0.013). The median cervical length was 29.9 and 31.2 mm for the no-atosiban and atosiban groups, respectively, and was not statistically significant (P = 0.28). There were no significant correlations between groups for the occurrence of PROM, GA at the time of PROM, duration of the procedures, parity, maternal body mass index (BMI) or age. In the univariate linear regression model, the only factor independently associated with GA at delivery was the use of atosiban during FETO procedures (β = 0.375; P < 0.013).
Conclusion
In cases of severe CDH treated with FETO, the use of atosiban as a tocolytic agent during the procedure prolonged pregnancy by 2 weeks. Cervical length, duration of FETO or maternal characteristics were not associated with GA at delivery.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2019 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Corner of Academy
- Multi-center results on the clinical use of KANET
- The use of atosiban prolongs pregnancy in patients treated with fetoscopic endotracheal occlusion (FETO)
- Original Articles – Obstetrics
- Evidence that intra-amniotic infections are often the result of an ascending invasion – a molecular microbiological study
- Advanced technology in obstetric education: a high-fidelity simulator for operative vaginal delivery
- Fetal adrenal gland size in gestational diabetes mellitus
- Characteristics of obstetric admissions to intensive care unit: APACHE II, SOFA and the Glasgow Coma Scale
- An investigation of vitamin and mineral supplement recommendation among first-trimester pregnancies
- Original Articles – Fetus
- Twin fetal facial expressions at 30–33+6 weeks of gestation
- Measurement of inferior facial angle and prefrontal space ratio in first trimester fetuses with aneuploidies: a retrospective study
- Original Articles – Newborns
- Factors affecting cerebrovascular reactivity to CO2 in premature infants
- Subcutaneous fat necrosis, a rare but serious side effect of hypoxic-ischemic encephalopathy and whole-body hypothermia
- Point-of-care ultrasound for peripherally inserted central catheter monitoring: a pilot study
- Acknowledgment
Articles in the same Issue
- Frontmatter
- Corner of Academy
- Multi-center results on the clinical use of KANET
- The use of atosiban prolongs pregnancy in patients treated with fetoscopic endotracheal occlusion (FETO)
- Original Articles – Obstetrics
- Evidence that intra-amniotic infections are often the result of an ascending invasion – a molecular microbiological study
- Advanced technology in obstetric education: a high-fidelity simulator for operative vaginal delivery
- Fetal adrenal gland size in gestational diabetes mellitus
- Characteristics of obstetric admissions to intensive care unit: APACHE II, SOFA and the Glasgow Coma Scale
- An investigation of vitamin and mineral supplement recommendation among first-trimester pregnancies
- Original Articles – Fetus
- Twin fetal facial expressions at 30–33+6 weeks of gestation
- Measurement of inferior facial angle and prefrontal space ratio in first trimester fetuses with aneuploidies: a retrospective study
- Original Articles – Newborns
- Factors affecting cerebrovascular reactivity to CO2 in premature infants
- Subcutaneous fat necrosis, a rare but serious side effect of hypoxic-ischemic encephalopathy and whole-body hypothermia
- Point-of-care ultrasound for peripherally inserted central catheter monitoring: a pilot study
- Acknowledgment
