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Prevalence and MRI findings of incidentally detected pituitary non-enhancing lesion on brain MRI in children

  • Hae Won Yoo , Jeong Rye Kim ORCID logo EMAIL logo and Jee Suk Yu
Published/Copyright: April 5, 2021
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 34 Issue 5

Abstract

Objectives

To determine the prevalence and MRI findings of incidentally detected pituitary nonenhancing lesion on brain MRI in children, and to compare the detection rates of pituitary nonenhancing lesion according to magnetic field strength and acquisition technique.

Methods

Pediatric patients (≤18 years old) who underwent brain MRI with contrast-enhancement between January 2018 and September 2019 were retrospectively included (n=365). The presence, size, and signal intensity of pituitary nonenhancing lesions were assessed by two radiologists. The prevalence of pituitary nonenhancing lesions was compared between different magnetic field strengths and MRI acquisition techniques.

Results

Pituitary nonenhancing lesions were identified in 76 patients (20.8%). The anteroposterior diameter of pituitary nonenhancing lesion was the smallest diameter in most patients (93.4%; mean diameter ± SD of 2.4 ± 1.5 mm; range: 0.9–9.0 mm). Sixty-seven percent of the pituitary nonenhancing lesions were hypointense on T1-weighted imaging, 44.1% were hyperintense on T2-weighted imaging, and 12.9% showed low signal intensity on susceptibility-weighted imaging. There was no diffusion restriction in any of the nonenhancing lesions. There was no significant difference in the prevalence of pituitary nonenhancing lesions according to magnetic field strength, age, gender, slice thickness, or 2D vs. 3D contrast-enhanced T1-weighted imaging sequence.

Conclusions

Pituitary nonenhancing lesions were identified on contrast-enhanced brain MRI in 20.8% of pediatric patients, with no significant difference in the prevalence according to magnetic field strength, slice thickness, and 2D or 3D contrast-enhanced T1-weighted imaging.

Keywords: children; MRI; nonenhancing lesion; pituitary gland; prevalence

Correction note

Correction added after online publication 19 April 2021: The order of first two authors has been changed.

Corresponding author: Jeong Rye Kim, MD, PhD, Department of Radiology, Dankook University Hospital, Dankook University College of Medicine, 201, Manghyang-ro, Dongnam-gu, Cheonan-si, Chungcheongnam-do, Republic of Korea, Phone: +82 41 550 6921, E-mail:

  1. Research funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

  2. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  3. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

  4. Ethical statement: This research has obtained a DKUH IRB-approved waiver of informed consent because this research involves no greater than minimal risk to participants, and the waiver will not adversely affect the rights and welfare of the participants. We certify that DKUH IRB is in full compliance with Good Clinical Practice as defined under the Korea Food and Drug Administration (KFDA) regulations and the International Conference on Harmonisation (ICH) guidelines.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/jpem-2020-0518).

Received: 2020-09-07
Accepted: 2021-02-02
Published Online: 2021-04-05
Published in Print: 2021-05-26

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jpem-2020-0518
Keywords for this article
children; MRI; nonenhancing lesion; pituitary gland; prevalence

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Covid19 pandemic and pediatric endocrinology and metabolism—Are we through with it?
  4. Original Articles
  5. Invisible burden of COVID-19: enzyme replacement therapy disruptions
  6. Anthropometric, biochemical and hormonal profiles of the partially admixed pygmoid group in Rampasasa (Flores, Indonesia)
  7. Etiologies, profile patterns and characteristics of children with short stature in Jordan
  8. Sexual maturity assessment in Indian children—a study from western India
  9. Bone density and bone health alteration in boys with Duchenne Muscular Dystrophy: a prospective observational study
  10. Sensory, voluntary, and motor postural control in children and adolescents with mucopolysaccharidosis
  11. Prevalence and MRI findings of incidentally detected pituitary non-enhancing lesion on brain MRI in children
  12. Oral glucose tolerance response curve predicts disposition index but not other cardiometabolic risk factors in healthy adolescents
  13. Early menarche is associated with insulin-resistance and non-alcoholic fatty liver disease in adolescents with obesity
  14. Liraglutide combined with intense lifestyle modification in the management of obesity in adolescents
  15. Exploring the inter-subject variability in the relationship between glucose monitoring metrics and glycated hemoglobin for pediatric patients with type 1 diabetes
  16. Screening for asymptomatic diabetes and metabolic comorbidities in pediatric patients during therapy for acute lymphoblastic leukemia
  17. Frequency and characterization of mutations in genes in a large cohort of patients referred to MODY registry
  18. Experience with the targeted next-generation sequencing in the diagnosis of hereditary hypophosphatemic rickets
  19. Newborn screening and molecular features of patients with multiple acyl-CoA dehydrogenase deficiency in Quanzhou, China
  20. Case Reports
  21. Dual diagnosis of Ochoa syndrome and Niemann-Pick disease type B in a consanguineous family
  22. Severe hypercalcemia in an infant with unbalanced translocation of chromosomes 2 and 8: a possible contribution of 2p duplication
  23. Epileptic phenotype in late-onset hyperinsulinemic hypoglycemia successfully treated by diazoxide
  24. Precocious sexual development in a male toddler caused by unrecognized transdermal exposure to testosterone: case report and review of the literature
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