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Leptin and adiponectin levels in discordant dichorionic twins at 72 hours of age-associations with anthropometric parameters and insulin resistance

  • Svetlana J. Milenković EMAIL logo , Ljiljana B. Mirković , Miljana Z. Jovandarić , Dušan M. Milenković , Violeta V. Banković and Borisav Z. Janković
Published/Copyright: March 17, 2017
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 30 Issue 4

Abstract

Background:

Insulin resistance (IR) in adults has been associated with intrauterine growth restriction (IUGR). Leptin and adiponectin correlations with anthropometric parameters and IR at 72 h in discordant twins were tested.

Methods:

We included 24 discordant (birth weight discordance ≥20% in relation to the heavier cotwin) and 30 concordant (birth weight discordance ≤10%) twins.

Results:

A correlation between leptin (but not adiponectin) level and birth weight (BW), birth length and head circumference in IUGR twins was recorded (p<0.05). Insulin sensitivity (IS) and homeostatic model assessment (HOMA)-IR in IUGR twins were similar to appropriate-for-gestational-age cotwins and unrelated to adipokines. In IUGR twins, adiponectin and insulin associated positively. In larger concordant twins’ leptin level correlated with HOMA-IR and insulin.

Conclusions:

Leptin, but not adiponectin, levels correlate positively with anthropometric parameters in IUGR twins. IR in IUGR twins is unrelated to adipokines in the first few days of life.

Keywords: adiponectin; fetal programming; insulin sensitivity (IS); intrauterine growth restriction (IUGR); leptin; twins

Acknowledgments

We gratefully acknowledge all of the pregnant women and their twins who participated in this study.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2016-9-14
Accepted: 2017-1-30
Published Online: 2017-3-17
Published in Print: 2017-4-1

©2017 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Pediatric endocrinology is pediatrics is public health
  4. Original Articles
  5. Total body fat, abdominal fat, body fat distribution and surrogate markers for health related to adipocyte fatty acid-binding protein (FABP4) in children
  6. Vitamin D supplementation, the metabolic syndrome and oxidative stress in obese children
  7. Vitamin D status in Egyptian children with type 1 diabetes and the role of vitamin D replacement in glycemic control
  8. Cross-sectional analysis of universal vitamin D supplementation in former East Germany during the first year of life
  9. Ethnicity and incidence of congenital hypothyroidism in the capital of Macedonia
  10. Changes of thyroid hormonal status in patients receiving ketogenic diet due to intractable epilepsy
  11. Leptin and adiponectin levels in discordant dichorionic twins at 72 hours of age-associations with anthropometric parameters and insulin resistance
  12. Analysis of growth hormone receptor gene expression in tall and short stature children
  13. Clinical features of girls with short stature among inv (9), Turner (45, X) and control individuals
  14. Hereditary vitamin D-resistant rickets in Lebanese patients: the p.R391S and p.H397P variants have different phenotypes
  15. Associations between obesity, adverse behavioral patterns and cardiovascular risk factors among adolescent inhabitants of a Greek island
  16. Increase of body mass index (BMI) from 1.5 to 3 years of age augments the degree of insulin resistance corresponding to BMI at 12 years of age
  17. Case Reports
  18. The variable clinical phenotype of three patients with hepatic glycogen synthase deficiency
  19. Molecular defects identified by whole exome sequencing in a child with atypical mucopolysaccharidosis IIIB
  20. Clinical presentation and treatment response to diazoxide in two siblings with congenital hyperinsulinism as a result of a novel compound heterozygous ABCC8 missense mutation
  21. Cushing’s syndrome in infancy due to ectopic ACTH secretion by a sacro-coccygeal teratoma
  22. Letters to the Editor
  23. Growth-hormone deficiency in mitochondrial disorders
  24. Response to Growth hormone deficiency in mitochondrial disorders
https://doi.org/10.1515/jpem-2016-0352
Keywords for this article
adiponectin; fetal programming; insulin sensitivity (IS); intrauterine growth restriction (IUGR); leptin; twins

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Pediatric endocrinology is pediatrics is public health
  4. Original Articles
  5. Total body fat, abdominal fat, body fat distribution and surrogate markers for health related to adipocyte fatty acid-binding protein (FABP4) in children
  6. Vitamin D supplementation, the metabolic syndrome and oxidative stress in obese children
  7. Vitamin D status in Egyptian children with type 1 diabetes and the role of vitamin D replacement in glycemic control
  8. Cross-sectional analysis of universal vitamin D supplementation in former East Germany during the first year of life
  9. Ethnicity and incidence of congenital hypothyroidism in the capital of Macedonia
  10. Changes of thyroid hormonal status in patients receiving ketogenic diet due to intractable epilepsy
  11. Leptin and adiponectin levels in discordant dichorionic twins at 72 hours of age-associations with anthropometric parameters and insulin resistance
  12. Analysis of growth hormone receptor gene expression in tall and short stature children
  13. Clinical features of girls with short stature among inv (9), Turner (45, X) and control individuals
  14. Hereditary vitamin D-resistant rickets in Lebanese patients: the p.R391S and p.H397P variants have different phenotypes
  15. Associations between obesity, adverse behavioral patterns and cardiovascular risk factors among adolescent inhabitants of a Greek island
  16. Increase of body mass index (BMI) from 1.5 to 3 years of age augments the degree of insulin resistance corresponding to BMI at 12 years of age
  17. Case Reports
  18. The variable clinical phenotype of three patients with hepatic glycogen synthase deficiency
  19. Molecular defects identified by whole exome sequencing in a child with atypical mucopolysaccharidosis IIIB
  20. Clinical presentation and treatment response to diazoxide in two siblings with congenital hyperinsulinism as a result of a novel compound heterozygous ABCC8 missense mutation
  21. Cushing’s syndrome in infancy due to ectopic ACTH secretion by a sacro-coccygeal teratoma
  22. Letters to the Editor
  23. Growth-hormone deficiency in mitochondrial disorders
  24. Response to Growth hormone deficiency in mitochondrial disorders
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