Home Medicine “My confidence in the diagnosis is low, but I am confident in what needs to happen for the patient”: a mixed-methods study exploring diagnostic confidence and its impact on physician well-being
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“My confidence in the diagnosis is low, but I am confident in what needs to happen for the patient”: a mixed-methods study exploring diagnostic confidence and its impact on physician well-being

  • Jennifer Sloane ORCID logo EMAIL logo , Roni Matin , Umber Shahid , Ashley N.D. Meyer ORCID logo , Hardeep Singh , Laura Zwaan ORCID logo and Traber D. Giardina
Published/Copyright: January 26, 2026
Diagnosis
From the journal Diagnosis

Abstract

Objectives

Uncertainty is inherent in diagnostic decision-making. While diagnostic uncertainty research continues to grow, research on diagnostic confidence remains underexplored. Research often uses simplified tools to measure confidence, overlooking the nuanced perspectives of physicians and leaving a limited understanding of the role confidence plays in the diagnostic process. We conducted a mixed-methods study to better understand diagnostic confidence, and ways confidence (or a lack thereof) impacts physicians’ well-being.

Methods

In this mixed-methods study, 20 semi-structured virtual interviews were conducted with practicing physicians across 16 hospitals. Participants reflected on cases where they felt “really” confident and “not-so-confident” in their final diagnoses. Confidence scales were included in the interviews to obtain quantitative measures of participants’ confidence in their final diagnoses and in their diagnostic processes for both cases discussed.

Results

Physicians conceptualize and report confidence differently for their final diagnoses compared to confidence in their diagnostic approaches. We found that physicians could maintain high levels of confidence in their diagnostic approaches, even in cases with considerable uncertainty in the final diagnoses. Additionally, our results showed that confidence in the diagnostic approach reflected more positively on physician well-being.

Conclusions

While physicians often feel uncertainty about their final diagnoses, they are better able to deal with this uncertainty if they are confident in the diagnostic approaches. Studying confidence in the diagnostic approach is key not only for obtaining a more complete understanding of the cognitive processes involved in diagnostic decision-making but also for improving physician well-being.


Corresponding author: Jennifer Sloane, Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey VA Medical Center, Houston, (MEDVAMC 152), 2002 Holcombe Blvd. 770230, TX, USA; and Department of Medicine, Baylor College of Medicine, Houston, TX, USA, E-mail:
This work was presented as a poster at the Society to Improve Diagnosis in Medicine annual conference in 2023.

Funding source: Houston Veterans Administration HSR&D

Award Identifier / Grant number: CIN13-413

Funding source: ZonMw

Award Identifier / Grant number: 09150172210015

Award Identifier / Grant number: R01HS028595

Award Identifier / Grant number: R18HS029347

Award Identifier / Grant number: R18HS029356

Award Identifier / Grant number: R01HS028595

Award Identifier / Grant number: R18HS029347

  1. Research ethics: This study was approved by Baylor College of Medicine IRB ID number: H-52974. Approval date: 1/5/2023.

  2. Informed consent: Informed consent was obtained from all individuals included in this study, or their legal guardians or wards.

  3. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission. The opinions expressed are those of the authors and not necessarily those of the Department of Veterans Affairs, the U.S. Government, or Baylor College of Medicine.

  4. Use of Large Language Models, AI and Machine Learning Tools: None declared.

  5. Conflict of interest: The authors state no conflict of interest.

  6. Research funding: This work is funded in part by the Houston Veterans Administration (VA) Health Services Research and Development (HSR&D) Center for Innovations in Quality, Effectiveness and Safety (CIN13–413). Additionally, Dr. Singh is funded in part by the Agency for Healthcare Research and Quality (R01HS028595 and R18HS029347). Dr Giardina is also funded in part by the Agency for Healthcare Research and Quality (R18HS029356). Dr. Zwaan is funded by a ZonMw Vidi grant number: 09150172210015 from the Netherlands Organisation for Health Research and Development.

  7. Data availability: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/dx-2025-0092).


Received: 2025-06-26
Accepted: 2025-12-13
Published Online: 2026-01-26

© 2025 Walter de Gruyter GmbH, Berlin/Boston

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