Maternal and fetal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGF BP-3, and their relationship to fetal acidosis at delivery
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Sharon M. Cooley
Abstract
Objective: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and in fetal cord blood at delivery.
Methods: Prospective cohort study of 1650 low-risk Caucasian women in a University teaching hospital in London. Statistical analysis was performed using commercial software (SPSS for Windows, version 6.1, SPSS, Chicago, Illinois, USA), with p < 0.05 as significant. Maternal IGF 1, IGF 2 and IGF BP-3 were assessed on maternal blood at booking and in fetal blood by cord blood analysis at delivery. Cord pH was also recorded.
Results: There was no significant correlation between maternal IGF-1, IGF-2, or IGFBP-3 levels and fetal acidosis. However, a significant correlation does exist between cord IGF-1 levels and fetal acidosis.
Conclusion: Fetal cord IGF-1 has a significant correlation with fetal acidosis at delivery.
References
1 Burrin JM, JL Patterson, PS Sharp, Yeo et al.: Monoclonal and polyclonal antibodies compared for radioimmunoassay of somatomedin-C in patients with acromegaly or hypopituitarism. Clin Chem33 (1987) 1593Search in Google Scholar
2 Zapf J, M Waldvogel, ER Froesch: Binding of non-suppressible insulin like activity to human serum. Evidence for a carrier protein. Arch Biochem Biophysics168 (1975) 638Search in Google Scholar
3 Hintz RL, F Liu: Demonstration of specific plasma protein binding sites for somatomedin. J Clin Endocrinol Metab45 (1977) 988Search in Google Scholar
4 Davis SR, SC Hodgkinson, LG Moore et al.: Improved estimates of clearance of 131 I-labelled insulin-like growth factor 1 carrier protein complexes from blood plasma of sheep. J Endocrinol123 (1989) 469Search in Google Scholar
5 Francis GL, JP McMurty, RJ Johnson et al.: Plasma clearance of chicken and human insulin-like growth factor-1 and their association with circulating binding proteins in chickens. J Endocrinol124 (1990) 361Search in Google Scholar
6 Hills FA, R Crawford, S Harding et al.: The effects of labor on maternal and fetal levels of insulin-like growth factor binding protein-1. Am J Obstet Gynecol171 (1994) 1292Search in Google Scholar
7 Crawford RAF, FA Hills, A Farkas et al.: Elevated levels of insulin-like growth factor binding protein-1 in fetal distress. Br J Obstet Gynaecol102 (1995) 538Search in Google Scholar
8 Wilson DM, A Bennett, GD Adamson et al.: Somatomedins in pregnancy: a cross-sectional study of IGF-I and II and SM peptide content in normal human pregnancies. J Clin Endocrinol Metab55 (1982) 858Search in Google Scholar
9 Hall K, E Enberg, E Hellem et al.: Somatomedin levels in pregnancy: longitudinal study in healthy subjects and patients with growth hormone deficiency. J Clin Endocrinol Metab59 (1984) 587Search in Google Scholar
10 Wang HS, CL Lee, T Chard: Levels of insulin-like growth factor-1 and insulin-like growth factor-binding protein-1 in pregnancy with preterm delivery. Br J Obstet Gynaecol100 (1993) 472Search in Google Scholar
11 Hills FA, J English, T Chard: Circulating levels of IGF-1 and IGF-binding protein-1 throughout pregnancy: relation to birthweight and maternal weight. J Endocrinol148 (1996) 303Search in Google Scholar
12 Holmes R, R Montemagno, J Jones et al.: Fetal and maternal plasma insulin-like growth factors and binding proteins in pregnancies with appropriate or retarded fetal growth. Early Hum Dev49 (1997) 7Search in Google Scholar
13 Wang HS, J Lim, J English et al.: The concentration of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-1 (IGFBP-1) in human umbilical cord serum at delivery: relation to fetal weight. J Endocrinol129 (1991) 459Search in Google Scholar
14 Hills FA, R Crawford, S Harding et al.: The effects of labor on maternal and fetal levels of insulin-like growth factor binding protein-1. Am J Obstet Gynecol171 (1994) 1292Search in Google Scholar
15 Crawford RAF, FA Hills, A Farkas et al.: Elevated levels of insulin-like growth factor binding protein-1 in fetal distress. Br J Obstet Gynaecol102 (1995) 538Search in Google Scholar
16 Office of Population Census and Surveys. Standard Occupational Classification, vol 3. London, Stationery Office 1991Search in Google Scholar
17 Freeman JV, TJ Cole, S Chinn et al.: Cross-sectional stature and weight reference curves for the UK, 1990. Arch Dis Child73 (1995) 17Search in Google Scholar
18 Verhaeghe J, R Van Bree, E Van Herck et al.: C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in umbilical cord serum: Correlations with birthweight. Am J Obstet Gynecol169 (1993) 89Search in Google Scholar
19 Gluckman PD, JJ Johnson-Barrett, JH Butler et al.: Studies of the insulin-like growth factor I and II by specific radioligands in umbilical cord blood. Clin Endocrinol19 (1983) 405Search in Google Scholar
20 Lassare C, S Hardouin, F Daffos et al.: Serum insulin-like growth factors and insulin-like growth factor binding proteins in the human fetus. relationships with growth in normal subjects and in subjects with intrauterine growth retardation. Pediatr Res29 (1991) 219Search in Google Scholar
21 Delmis J, A Drazancic, M Ivanisevic et al.: Glucose, insulin, HGH and IGF-I levels in maternal serum, amniotic fluid and umbilical venous serum: a comparison between late normal pregnancy and pregnancies complicated with diabetes and fetal growth retardation. J Perinat Med20 (1992) 47Search in Google Scholar
22 Reece EA, A Wizniter, E Le et al.: The relation between human fetal growth and fetal blood levels of insulin-like growth factors I and II, their binding proteins, and receptors. Obstet Gynecol84 (1994) 88Search in Google Scholar
23 Giudice LC, F de Zegher, SE Gargosky et al.: Insulin-like growth factors and their binding proteins in the term and preterm fetus and neonate with normal and extremes of intrauterine growth. J Clin Endocrinol Metab80 (1995) 1548Search in Google Scholar
24 Bernstein I, MI Goran, KC Copeland: Maternal insulin sensitivity and cord blood peptides: relationships to neonatal size at birth. Obstet Gynecol90 (1997) 780Search in Google Scholar
25 Wizniter A, EA Reece, C Homko et al.: Insulin-like growth factors, their binding proteins, and fetal macrosomia in offspring of nondiabetic pregnant women. Am J Perinatol15 (1998) 23Search in Google Scholar
26 Wang HS, T Chard: The role of insulin-like growth factor-1 and insulin-like growth factor-binding protein-1 in the control of human fetal growth. J Endocrinol132 (1991) 1Search in Google Scholar
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Articles in the same Issue
- Fetal membrane inflammatory cytokines: a switching mechanism between the preterm premature rupture of the membranes and preterm labor pathways
- Preeclampsia – abnormal uterine artery Doppler is related to recurrence of symptoms during the next pregnancy
- Mother-to-infant vertical transmission of transfusion transmitted virus in South China
- Evaluation of second trimester maternal serum screening for Down’s Syndrome using the Spiegelhalter-Knill-Jones (S-KJ) approach
- β2-adrenergic receptor gene polymorphisms and pregnancy outcome
- Maternal and fetal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGF BP-3, and their relationship to fetal acidosis at delivery
- Comparison of intrapartum fetal heart rate tracings in patients with neonatal seizures vs. no seizures: what are the differences?
- Computerized cardiotocography parameters in pregnant women affected by pregestational diabetes mellitus
- The effect of processing and cryopreservation on nucleated umbilical cord blood cells
- Etiology of cerebral palsy
- Characterisation of the cytokine inflammatory response in LPS stimulated full-term cord blood
- Amniotic cavity cultures, blood cultures, and surface swabs in preterm infants – useful tools for the management of early-onset sepsis?
- Massive hepatic infarction in preeclampsia: successful treatment with continuous hemodiafiltration and corticosteroid therapy
- The use of recombinant factor VIIa in a primigravida with Glanzmann’s thrombasthenia during delivery
- Potential harm from puncture resistant surgical gloves