Coagulation and fibrinolysis in viable mid-trimester pregnancies of normal, intrauterine growth retardation, chromosomal anomalies and hydrops fetalis and their eventual obstetric outcome
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Stephen C. L. Koh
Abstract
A total of 71 pregnant women diagnosed by ultrasound to have viable fetus in late mid-trimester pregnancies of normal, IUGR, hydrops fetalis and chromosomal anomalies were studied for their coagulation, fibrinolytic and inhibitor levels with association on eventual obstetrics outcome. A hypercoagulable state was observed in all the pregnancies studied. However, higher hypercoagulation evidenced by significantly raised prothrombin formation and clot elasticity together with higher levels of D-dimer, uPA antigen and PAI-1 than observed in normal pregnancy suggests a hyperfibrinolytic/inhibitor state in hydrops fetalis pregnancy associated with bad obstetric outcome. In IUGR pregnancy associated with good outcome further enhanced clot elasticity was seen whilst no significant differences were observed in pregnancy with chromosomal anomalies when compared to uncomplicated normal pregnancy. Our study suggests that in hydrops fetalis pregnancy, further enhanced prothrombin formation and hyperfibrinolysis/inhibitor at late mid-trimester is associated with a poor obstetric outcome.
Copyright (c)1999 by Walter de Gruyter GmbH & Co. KG
Articles in the same Issue
- Contents
- Author Index
- Subject Index
- Birth of St. Mary (St. Anne’s parturition) in the light of messages from medical education: Three examples from Croatian sacral heritage
- Are color and pulsed Doppler sonography safe in early pregnancy?
- European Community Multi-Center Trial “Fetal ECG Analysis During Labor”: ST plus CTG analysis
- Prenatal and perinatal risk factors for autism
- Rupture of membranes before 26 weeks of gestation: Outcome of 148 consecutive cases
- Coagulation and fibrinolysis in viable mid-trimester pregnancies of normal, intrauterine growth retardation, chromosomal anomalies and hydrops fetalis and their eventual obstetric outcome
- Determinants of energy expenditure in ventilated preterm infants
- Perinatal outcome and management of single fetal death in twin pregnancy: A case series and review
- Comparison between creatine kinase brain isoenzyme (CKBB) activity and Sarnat score for prediction of adverse outcome following perinatal asphyxia
- Neonatal outcome in small for gestational age infants: Do they really better?
- Chronic lung disease and survival in 4 tertiary neonatal units
- Follow-up studies of newborn-babies with congenital ventriculomegaly
Articles in the same Issue
- Contents
- Author Index
- Subject Index
- Birth of St. Mary (St. Anne’s parturition) in the light of messages from medical education: Three examples from Croatian sacral heritage
- Are color and pulsed Doppler sonography safe in early pregnancy?
- European Community Multi-Center Trial “Fetal ECG Analysis During Labor”: ST plus CTG analysis
- Prenatal and perinatal risk factors for autism
- Rupture of membranes before 26 weeks of gestation: Outcome of 148 consecutive cases
- Coagulation and fibrinolysis in viable mid-trimester pregnancies of normal, intrauterine growth retardation, chromosomal anomalies and hydrops fetalis and their eventual obstetric outcome
- Determinants of energy expenditure in ventilated preterm infants
- Perinatal outcome and management of single fetal death in twin pregnancy: A case series and review
- Comparison between creatine kinase brain isoenzyme (CKBB) activity and Sarnat score for prediction of adverse outcome following perinatal asphyxia
- Neonatal outcome in small for gestational age infants: Do they really better?
- Chronic lung disease and survival in 4 tertiary neonatal units
- Follow-up studies of newborn-babies with congenital ventriculomegaly
