Article
Licensed
Unlicensed
Requires Authentication
Cardiovascular risk factors and γ-glutamyltransferase fractions in healthy individuals
-
Maria Franzini
Published/Copyright:
February 17, 2010
Abstract
Background: Serum γ-glutamyltransferase activity (GGT), even when within its normal reference range, catalyzes low density lipoprotein oxidation in vitro and predicts cardiovascular events. Of the four GGT fractions (b-GGT, m-GGT, s-GGT, and f-GGT) recently identified in blood, only b-GGT is found within atherosclerotic plaques. Our goal was to identify the determinants of the GGT fractions (b-, m-, s-, and f-GGT) and their association with established cardiovascular risk factors in healthy subjects.
Methods: Multiple linear regression analysis was applied to estimate the association of fractional GGT with gender, age, body mass index, arterial pressure (AP), plasma glucose, alanine aminotransferase (ALT), high and low density lipoproteins (LDL-C) cholesterol (HDL-C), triglycerides (TG) and C-reactive protein (CRP) in 200 healthy subjects.
Results: All GGT fractions were associated with ALT; b-GGT with AP, TG, and CRP; m-GGT with LDL-C, TG and CRP; s-GGT with TG and CRP, and f-GGT only with LDL-C, whereas gender was associated with s-GGT and f-GGT only.
Conclusions: In healthy individuals, cardiovascular risk factors are associated with high molecular weight GGT fractions, namely with b-GGT, the only form present within the plaque. This finding adds to the present knowledge concerning the relevance of GGT, within its reference range, for atherosclerosis-related events.
Clin Chem Lab Med 2010;48:713–7.
Keywords: γ-glutamyltransferase activity; γ-glutamyltransferase fractions; gel filtration chromatography; risk factors
Received: 2009-8-1
Accepted: 2009-12-23
Published Online: 2010-02-17
Published in Print: 2010-05-01
©2010 by Walter de Gruyter Berlin New York
You are currently not able to access this content.
You are currently not able to access this content.
Articles in the same Issue
- Editorials
- Laboratory medicine and natural disasters: are we ready for the challenge?
- Reference values: still a critical issue in laboratory medicine
- Review
- Contemporary platelet function testing
- Minireviews
- Disasters: where they find us
- Inter-laboratory variation in cerebrospinal fluid biomarkers for Alzheimer's disease: united we stand, divided we fall
- Opinion Paper
- Glycated hemoglobin (HbA1c): old dogmas, a new perspective?
- Guidelines and Recommendations
- IFCC reference procedures for measurement of the catalytic concentrations of enzymes: corrigendum, notes and useful advice
- Recommendations for the implementation of international standardization of glycated hemoglobin in Italy
- Genetics and Molecular Diagnostics
- UGT2B17 and SULT1A1 gene copy number variation (CNV) detection by LabChip microfluidic technology
- Genetic polymorphisms of CYP1A2, CYP3A4, CYP3A5, pregnane/steroid X receptor and constitutive androstane receptor in 207 healthy Spanish volunteers
- Automated genomic DNA extraction from saliva using the QIAxtractor
- General Clinical Chemistry and Laboratory Medicine
- A new statistical method for evaluating long-term analytical performance of laboratories applied to an external quality assessment scheme for flow cytometry
- Evaluation of the Becton-Dickinson rapid serum tube: does it provide a suitable alternative to lithium heparin plasma tubes?
- Immunoglobulin M antibodies to aquaporin-4 in neuromyelitis optica and related disorders
- Evaluation of the new body fluid mode on the Sysmex XE-5000 for counting leukocytes and erythrocytes in cerebrospinal fluid and other body fluids
- Extracellular haemoglobin, oxidative stress and quality of red blood cells relative to perioperative blood salvage
- Positive predictive value of serological diagnostic measures in celiac disease
- Retinol potentiates the inhibitory effect of ascorbic acid on uric acid assay
- Reference Values and Biological Variations
- Reference intervals for brain natriuretic peptide in healthy newborns and infants measured with an automated immunoassay platform
- Factors influencing serum total tryptase concentrations in a general adult population
- Leptin and adiponectin levels in pubertal children: relationship with anthropometric variables and body composition
- Cardiovascular risk factors and γ-glutamyltransferase fractions in healthy individuals
- Cancer Diagnostics
- Combined analysis of survivin autoantibody and carcinoembryonic antigen biomarkers for improved detection of colorectal cancer
- Oligoclonal bands and immunoglobulin isotype switch during monitoring of patients with multiple myeloma and autologous hematopoietic cell transplantation: a 16-year experience
- Letters to the Editor
- Methodological weakness in using correlation coefficients for assessing the interchangeability of analyte data between samples collected under different sampling conditions – the example of matrix metalloproteinase 9 determined in serum and plasma samples
- Intralipid causes falsely increased glucose concentrations with the Hemocue glucose analyzer
- Serum cholesterol: required and actual bias values
- Abstracts
- ISMD2010 Eighth International Symposium on Molecular Diagnostics
Keywords for this article
γ-glutamyltransferase activity;
γ-glutamyltransferase fractions;
gel filtration chromatography;
risk factors
Articles in the same Issue
- Editorials
- Laboratory medicine and natural disasters: are we ready for the challenge?
- Reference values: still a critical issue in laboratory medicine
- Review
- Contemporary platelet function testing
- Minireviews
- Disasters: where they find us
- Inter-laboratory variation in cerebrospinal fluid biomarkers for Alzheimer's disease: united we stand, divided we fall
- Opinion Paper
- Glycated hemoglobin (HbA1c): old dogmas, a new perspective?
- Guidelines and Recommendations
- IFCC reference procedures for measurement of the catalytic concentrations of enzymes: corrigendum, notes and useful advice
- Recommendations for the implementation of international standardization of glycated hemoglobin in Italy
- Genetics and Molecular Diagnostics
- UGT2B17 and SULT1A1 gene copy number variation (CNV) detection by LabChip microfluidic technology
- Genetic polymorphisms of CYP1A2, CYP3A4, CYP3A5, pregnane/steroid X receptor and constitutive androstane receptor in 207 healthy Spanish volunteers
- Automated genomic DNA extraction from saliva using the QIAxtractor
- General Clinical Chemistry and Laboratory Medicine
- A new statistical method for evaluating long-term analytical performance of laboratories applied to an external quality assessment scheme for flow cytometry
- Evaluation of the Becton-Dickinson rapid serum tube: does it provide a suitable alternative to lithium heparin plasma tubes?
- Immunoglobulin M antibodies to aquaporin-4 in neuromyelitis optica and related disorders
- Evaluation of the new body fluid mode on the Sysmex XE-5000 for counting leukocytes and erythrocytes in cerebrospinal fluid and other body fluids
- Extracellular haemoglobin, oxidative stress and quality of red blood cells relative to perioperative blood salvage
- Positive predictive value of serological diagnostic measures in celiac disease
- Retinol potentiates the inhibitory effect of ascorbic acid on uric acid assay
- Reference Values and Biological Variations
- Reference intervals for brain natriuretic peptide in healthy newborns and infants measured with an automated immunoassay platform
- Factors influencing serum total tryptase concentrations in a general adult population
- Leptin and adiponectin levels in pubertal children: relationship with anthropometric variables and body composition
- Cardiovascular risk factors and γ-glutamyltransferase fractions in healthy individuals
- Cancer Diagnostics
- Combined analysis of survivin autoantibody and carcinoembryonic antigen biomarkers for improved detection of colorectal cancer
- Oligoclonal bands and immunoglobulin isotype switch during monitoring of patients with multiple myeloma and autologous hematopoietic cell transplantation: a 16-year experience
- Letters to the Editor
- Methodological weakness in using correlation coefficients for assessing the interchangeability of analyte data between samples collected under different sampling conditions – the example of matrix metalloproteinase 9 determined in serum and plasma samples
- Intralipid causes falsely increased glucose concentrations with the Hemocue glucose analyzer
- Serum cholesterol: required and actual bias values
- Abstracts
- ISMD2010 Eighth International Symposium on Molecular Diagnostics
