Synthesis and antifungal activity of alkyland arylsulfanylpyridinylguanidines
-
K. Palát
,
G. Braunerová
Abstract
A series of alkyl- and arylsulfanylpyridylguanidines was synthesized and their antimicrobial activity was evaluated in vitro against eight potentially pathogenic strains of fungi. Compounds with an alkylsulfanyl substitution have antifungal activity, which improves with increasing length of the aliphatic chain.
[1] Ryuji, M., Shunsuke, S., and Masao, T., U.S. 4341769(1982). Suche in Google Scholar
[2] Bhongade, B. A. and Gadad, A. K., J. Med. Chem. 49, 475 (2006). http://dx.doi.org/10.1021/jm050149r10.1021/jm050149rSuche in Google Scholar
[3] Barber, C. G., Dickinson, R. P., and Horne, V. A., Bioorg. Med. Chem. Lett. 12, 181 (2002). http://dx.doi.org/10.1016/S0960-894X(01)00701-610.1016/S0960-894X(01)00701-6Suche in Google Scholar
[4] Barber, C. G. and Dickinson, R. P., EP 1044967 (2000). Suche in Google Scholar
[5] Braunerová, G., Buchta, V., Silva, L., Kuneš, J., and Palát, K. Jr., Farmaco 59, 443 (2004). http://dx.doi.org/10.1016/j.farmac.2004.03.00110.1016/j.farmac.2004.03.001Suche in Google Scholar PubMed
[6] McKee, R. H., Am. Chem. J. 26, 209 (1901). Suche in Google Scholar
[7] Rajsner, M., Metyšová, J., Svátek, E., MiksÍk, F., and Protiva, M., Collect. Czech. Chem. Commun. 40, 719 (1975). Suche in Google Scholar
[8] Uher, M., Antos, K., Kristian, P., and Drobnica, L., Chem. Zvesti 21 44 (1967). Suche in Google Scholar
[9] Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts. Document M27-A. National Committee for Clinical Laboratory Standards, Wayne, Pa, 1997. Suche in Google Scholar
[10] Reference Method for Broth Dilution Antifungal Susceptibility Testing of Conidium-Forming Filamentous Fungi. Document M38-P. National Committee for Clinical Laboratory Standards, Wayne, Pa, 1998. Suche in Google Scholar
© 2007 Institute of Chemistry, Slovak Academy of Sciences
Artikel in diesem Heft
- Peroxynitrite: In vivo and In vitro synthesis and oxidant degradative action on biological systems regarding biomolecular injury and inflammatory processes
- Coupling of microwave induced plasma optical emission spectrometry with HPLC separation for speciation analysis of Cr(III)/Cr(VI)
- Determination of nitrites by the formation of bisazo dye
- Determination of As(III) and total as in water by graphite furnace atomic absorption spectrometry after electrochemical preconcentration on a gold-plated porous glassy carbon electrode
- Exergoecological analysis of processing of SO2-containing gases from zinc production
- Chromaticity of poly(o-toluidine) matrix enhanced by anion-exchange mechanism
- Ethanol/water pulp enzymatic pretreatment: Chemical and FTIR-PCA analyses
- Study of controlled tetracycline release from porous calcium phosphate/polyhydroxybutyrate composites
- Spectroscopic and thermodynamic studies of complexation of some divalent metal ions with isatin-β-thiosemicarbazone
- Structural and spectroscopic analysis of dipeptide l-methionyl-glycine and its hydrochloride
- Excess molar volumes of the (cyclohexane + pentane, or hexane, or heptane, or octane, or nonane) systems at the temperature 298.15 K
- Solid-state vibrational spectra and theoretical study of alaninamide acetate
- Synthesis and antifungal activity of alkyland arylsulfanylpyridinylguanidines
- Isolation and identification of flower oil components from four Staphylea L. species
Artikel in diesem Heft
- Peroxynitrite: In vivo and In vitro synthesis and oxidant degradative action on biological systems regarding biomolecular injury and inflammatory processes
- Coupling of microwave induced plasma optical emission spectrometry with HPLC separation for speciation analysis of Cr(III)/Cr(VI)
- Determination of nitrites by the formation of bisazo dye
- Determination of As(III) and total as in water by graphite furnace atomic absorption spectrometry after electrochemical preconcentration on a gold-plated porous glassy carbon electrode
- Exergoecological analysis of processing of SO2-containing gases from zinc production
- Chromaticity of poly(o-toluidine) matrix enhanced by anion-exchange mechanism
- Ethanol/water pulp enzymatic pretreatment: Chemical and FTIR-PCA analyses
- Study of controlled tetracycline release from porous calcium phosphate/polyhydroxybutyrate composites
- Spectroscopic and thermodynamic studies of complexation of some divalent metal ions with isatin-β-thiosemicarbazone
- Structural and spectroscopic analysis of dipeptide l-methionyl-glycine and its hydrochloride
- Excess molar volumes of the (cyclohexane + pentane, or hexane, or heptane, or octane, or nonane) systems at the temperature 298.15 K
- Solid-state vibrational spectra and theoretical study of alaninamide acetate
- Synthesis and antifungal activity of alkyland arylsulfanylpyridinylguanidines
- Isolation and identification of flower oil components from four Staphylea L. species
