Study of controlled tetracycline release from porous calcium phosphate/polyhydroxybutyrate composites
-
L’ Medvecký
,
R. Štulajterová
Abstract
Porous calcium phosphate ceramics were prepared by sintering of mixtures of nanocrystalline apatitic calcium phosphate and fibrous natural cotton cellulose after pressing at temperatures of 1150 °C and 1250 °C. Micro-and macropores were present in microstructures of ceramic samples. The microstructures of porous ceramics were similar to those observed in bone tissues and fiber-like randomly oriented texture was observed in ceramics. Polyhydroxybutyrate (PHB) biopolymer layers are distributed homogeneously in the samples after evaporation of the diluent (chloroform) from the PHB vacuum impregnated porous samples. The tetracycline (TTC) release rate decreases with the content of polyhydroxybutyrate in the ceramic samples, which corresponds to the rise in amount of biopolymer displaced in the pores of ceramics. The concentration of TTC in the phosphate buffer saline solution varies almost linearly with time after the first seven hours from the start of the release of the calcium phosphate ceramic samples with 2.4 mass % of polyhydroxybutyrate. The initial burst effect was significantly depressed by the preparation method used.
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© 2007 Institute of Chemistry, Slovak Academy of Sciences
Artikel in diesem Heft
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Artikel in diesem Heft
- Peroxynitrite: In vivo and In vitro synthesis and oxidant degradative action on biological systems regarding biomolecular injury and inflammatory processes
- Coupling of microwave induced plasma optical emission spectrometry with HPLC separation for speciation analysis of Cr(III)/Cr(VI)
- Determination of nitrites by the formation of bisazo dye
- Determination of As(III) and total as in water by graphite furnace atomic absorption spectrometry after electrochemical preconcentration on a gold-plated porous glassy carbon electrode
- Exergoecological analysis of processing of SO2-containing gases from zinc production
- Chromaticity of poly(o-toluidine) matrix enhanced by anion-exchange mechanism
- Ethanol/water pulp enzymatic pretreatment: Chemical and FTIR-PCA analyses
- Study of controlled tetracycline release from porous calcium phosphate/polyhydroxybutyrate composites
- Spectroscopic and thermodynamic studies of complexation of some divalent metal ions with isatin-β-thiosemicarbazone
- Structural and spectroscopic analysis of dipeptide l-methionyl-glycine and its hydrochloride
- Excess molar volumes of the (cyclohexane + pentane, or hexane, or heptane, or octane, or nonane) systems at the temperature 298.15 K
- Solid-state vibrational spectra and theoretical study of alaninamide acetate
- Synthesis and antifungal activity of alkyland arylsulfanylpyridinylguanidines
- Isolation and identification of flower oil components from four Staphylea L. species
