Mathematical Modeling of Drug Release from Spherical Drug Particles: Analysis of the Effect of Absorption Rate on Drug Release Rate
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Norman W Loney
A closed form solution has been obtained for the release kinetics of a solute from a spherical drug matrix into a finite volume of liquid, taking into account the effect of rate of absorption. The proposed model results clearly show the effect of the absorption rate constant on the rate of drug release. The obtained results are compared with the experimental data and diffusion-only model results. There is a significant difference in the release profile when the rate of absorption of drug is slow. The most important feature of the mathematical relationship between the liquid concentration verses time is its ability to predict change in the performance of the drug by manipulating the parameters of the equation. These parameters include the initial concentration of the drug, the radius of the drug and diffusivity of the drug in the solid to name a few. Therefore, a substantial number of experiments can be eliminated when the optimal performance of a drug is sought after.
©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston
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- Article
- Editorial: Special Issue of 8th World Congress of Chemical Engineering (WCCE 8) Symposium on Process Design
- Reactive Dividing-Wall Columns - Defying Equilibrium Restrictions
- Fractal Scaling in Crude Oil Price Evolution via Time Series Analysis of Historical Data
- Effect of Sound Wave Irradiation on Methane Conversion in DC Pulse Discharge Plasma
- The Production of Polyhydroxyalkanoates Using an Oscillatory Baffled Bioreactor
- Simultaneous Coke Reduction with Improved Syngas Production during Propane Steam Reforming using Forced CO2 Cycling
- Kernel PCA Performance in Processes with Multiple Operation Modes
- A New Kinetic Model for 4-Chlorophenol Adsorption on Expanded Clay
- Uniformly Bounded Error Estimator for Bioprocess with Unstructured Cell Growth Models
- Mathematical Modeling of Drug Release from Spherical Drug Particles: Analysis of the Effect of Absorption Rate on Drug Release Rate
- Analysis on a Counter-Current Flow Hemodialyzer
- Mathematical Model of a Falling Film Reactor for Methyl Ester Sulfonation
- Oxidative Coupling of Propane with a Two-Layered Catalyst Bed Reactor
- Interval Based MINLP Superstructure Synthesis of Multi-Period Mass Exchanger Networks
- Modeling Fluid Separation Processes Using a Complementary Approach
- Compartmental Modeling of an Industrial Column
- Recrystallization of Caffeine Using Supercritical Carbon Dioxide as Antisolvent
- Flow Characteristics in an Airlift Membrane Bioreactor
- Design and Control of Integrated Styrene-Aniline Production Plant
