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Structural characterization of arbidol®
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Vladimir V. Chernyshev
Veröffentlicht/Copyright:
1. September 2011
Abstract
Crystal structures of two compounds – 1-methyl-2-phenylthiomethyl-3-carbethoxy-4-dimetylaminomethyl-5-hydroxy-6-bromoindole (1) and its hydrochloride monohydrate (2), known also as antiviral drug arbidol®, were determined from single-crystal and powder diffraction data, respectively. In 1, the hydroxyl and dimethyläamino groups are involved in a strong intramolecular O—H…N hydrogen bond [O…N 2.550(4) Å]. In 2, the protonation site is dimethylamino group but not the carbon bearing the ester group.
Keywords: Arbidol®; powder diffraction structure analysis; Single crystal structure analysis; X-ray diffraction
Published Online: 2011-09-01
Published in Print: 2011-11
© by Oldenbourg Wissenschaftsverlag, Moscow, Germany
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- Crystal structure of the ternary compound γ-Al3FeSi
- Ab initio study of the properties of CuAlSe2: A chalcopyrite compound
- Crystal structures of thiazine-indigo pigments, determined from single-crystal and powder diffraction data
- Structural characterization of arbidol®
- (2-Amidoethyl)trichlorotin(IV)complexes with amido ligands and chloride ion: supramolecular arrays from H-bonds involving the amido and chloride ions
- Crystal structures of hydrazones, 2-(1,3-benzothiazolyl)-NH—N=CH—Ar, prepared from arenealdehydes and 2-hydrazinyl-1,3-benzothiazole
- Synthesis, X-ray crystal structure and theoretical study of 4-ethyl-5-(2-thienyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione; structural comparison with its aromatic analogs
Schlagwörter für diesen Artikel
Arbidol®;
powder diffraction structure analysis;
Single crystal structure analysis;
X-ray diffraction
Artikel in diesem Heft
- Crystal structure of the ternary compound γ-Al3FeSi
- Ab initio study of the properties of CuAlSe2: A chalcopyrite compound
- Crystal structures of thiazine-indigo pigments, determined from single-crystal and powder diffraction data
- Structural characterization of arbidol®
- (2-Amidoethyl)trichlorotin(IV)complexes with amido ligands and chloride ion: supramolecular arrays from H-bonds involving the amido and chloride ions
- Crystal structures of hydrazones, 2-(1,3-benzothiazolyl)-NH—N=CH—Ar, prepared from arenealdehydes and 2-hydrazinyl-1,3-benzothiazole
- Synthesis, X-ray crystal structure and theoretical study of 4-ethyl-5-(2-thienyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione; structural comparison with its aromatic analogs
