Development of a radiothallium (III) labeld porphyrin complex as a potential imaging agent
-
Y. Fazaeli
,
S. Feizi
Abstract
Since 201Tl is widely used in SPECT and porphyrins are important biological carriers, we tried to obtain a stable complex between thallium and porphyrins. The thallium porphyrin complex was synthesized by reaction of 201Tl(III) with porphyrin at 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin (H2PFPP) for 60 min at 100°C. The complex was analysed via TLC and HPLC stability (in the final formulation and human serum) and the partition coefficient of the complex was determined. The biodistribution of the labeled compound in vital organs of wild-type rats was investigated. The complex was prepared with high radiochemical purity (> 99% ITLC, > 99% HPLC, specific activity: 13–14 GBq/mmol) (log P = 1.92). The stability of the Tl+3-complex seems to be low since the complex or free thallium is rapidly cleared through the kidneys and the liver.
© 2013 by Walter de Gruyter Berlin Boston
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Artikel in diesem Heft
- Masthead
- Masthead
- Predictions of redox potentials of Sg in acid solutions as a function of pH
- Am(III) separation from acidic solutions by diamides of dipicolinic acid
- PC-88A – impregnated polymeric beads: Preparation, characterization and application for extraction of Pu(IV) from nitric acid medium
- Studies on the transport of actinides and lanthanides through DHDECMPO based supported liquid membranes (SLM)
- Applicability of Raman spectroscopy as a tool in nuclear forensics for analysis of uranium ore concentrates
- Study on the acid–base surface property of the magnetite graphene oxide and its usage for the removal of radiostrontium from aqueous solution
- Development of a radiothallium (III) labeld porphyrin complex as a potential imaging agent
- Sources of variability in the determination by evaporation method of gross alpha activity in water samples
