Essential oil chemical composition, antimicrobial, anticancer, and antioxidant effects of Thymus convolutus Klokov in Turkey
-
Selma Celen Yuceturk
,
Sumeyye Aydogan Turkoglu
,
Feray Kockar
,
F. Zehra Kucukbay
und
A. Dilek Azaz
Abstract
In this study, the chemical composition, antimicrobial, antioxidant, and anticancer effects of Thymus convolutus Klokov oil and its main compound camphor were investigated. The oil was isolated from T. convolutus using hydrodistillation method, analyzed by gas chromatography/mass spectrometry (GC–MS), and 66 compounds were identified. The main component was determined as camphor at 16.6%. The antioxidant properties were identified with the DPPH (2,2′-diphenyl-1-picrylhydrazyl) radical-scavenging method and, 33.39 ± 0.25% DPPH was scavenging in 1000 μg/mL of essential oil. The strong antimicrobial activity was observed against Escherichia coli, Enterobacter aerogenes, Proteus vulgaris, and Pseudomonas aeruginosa with MIC values of 125 μg/mL. Aspergillus flavus was more sensitive (28%) against T. convolutus essential oil than other fungi. The cytotoxic effect of oil was analyzed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. Camphor was effective on human hepatoma cells (Hep3B) at concentrations of 1 mg/mL, 500, 250, and 125 μg/mL, while essential oil of T. convolutus was found to be effective at concentrations of 250 and 125 μg/mL. A reduction in cell proliferation was observed in colon carcinoma cells (HT-29) treated with 500 μg/mL camphor for 48 h. No statistically significant effect was found in Umbilical Vein Endothelial Cells (HUVEC) treated with essential oil and camphor.
Funding source: Balikesir University Research Fund
Award Identifier / Grant number: 2009/22
Acknowledgments
The authors want to thank Balikesir University Research Fund (Project No: 2009/22) for its financial support and also we would like to thank Prof. Dr. Bayram Yildiz for helps the field studies and identification of the Thymus species.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: This study was funded by Balikesir University Research Fund (Project No: 2009/22).
Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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© 2021 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Research Articles
- Chemical composition, antioxidant and antimicrobial activity of essential oils from tangerine (Citrus reticulata L.), grapefruit (Citrus paradisi L.), lemon (Citrus lemon L.) and cinnamon (Cinnamomum zeylanicum Blume)
- Down-regulation of SORL1 is associated with Alzheimer’s disease through activating ABC transporter pathway
- Essential oil chemical composition, antimicrobial, anticancer, and antioxidant effects of Thymus convolutus Klokov in Turkey
- Analysis and chemotaxonomic significance of pyrrolizidine alkaloids from two Boraginaceae species growing in Algeria
- Halo-phenolic metabolites and their in vitro antioxidant and cytotoxic activities from the Red Sea alga Avrainvillea amadelpha
- PEPPSI complexes as potential prodrugs: enzyme inhibition, antioxidant activity, electrochemical characterization, molecular docking analysis
- Anti-Leishmania activity of extracts from Piper cabralanum C.DC. (Piperaceae)
- Anticancer Cardenolides from the aerial parts of Calortopis procera
- Cytotoxic withanolides from Datura innoxia
- Book Review
- A. Sigel, E. Freisinger & R. K. O. Sigel (Eds.), M. E. Sosa Torres & P. M. H. Kroneck (volume Eds.): Transition Metals and Sulfur – A Strong Relationship for Life
Artikel in diesem Heft
- Frontmatter
- Research Articles
- Chemical composition, antioxidant and antimicrobial activity of essential oils from tangerine (Citrus reticulata L.), grapefruit (Citrus paradisi L.), lemon (Citrus lemon L.) and cinnamon (Cinnamomum zeylanicum Blume)
- Down-regulation of SORL1 is associated with Alzheimer’s disease through activating ABC transporter pathway
- Essential oil chemical composition, antimicrobial, anticancer, and antioxidant effects of Thymus convolutus Klokov in Turkey
- Analysis and chemotaxonomic significance of pyrrolizidine alkaloids from two Boraginaceae species growing in Algeria
- Halo-phenolic metabolites and their in vitro antioxidant and cytotoxic activities from the Red Sea alga Avrainvillea amadelpha
- PEPPSI complexes as potential prodrugs: enzyme inhibition, antioxidant activity, electrochemical characterization, molecular docking analysis
- Anti-Leishmania activity of extracts from Piper cabralanum C.DC. (Piperaceae)
- Anticancer Cardenolides from the aerial parts of Calortopis procera
- Cytotoxic withanolides from Datura innoxia
- Book Review
- A. Sigel, E. Freisinger & R. K. O. Sigel (Eds.), M. E. Sosa Torres & P. M. H. Kroneck (volume Eds.): Transition Metals and Sulfur – A Strong Relationship for Life
