Three new coumarin types from aerial parts of Ammi majus L. and their cytotoxic activity
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Eman El-Sharkawy
Abstract
Three new coumarin types were isolated from the aerial parts of the wild medicinal plant Ammi majus, which was collected from western Asia (Saudi Arabia), including pyrano coumarin, namely, 5-isobutylcoumarin-6-C-glucoside (1); furanocoumarin, namely, 6,7,9-Trimethoxy-3-(8′-methoxy-2′-oxo-2H-chromen-3-yl)-2H-furo[3,2-g]chromen-2(3H)-one (2); and pyrone coumarin, namely, 6-hydroxy-3-(2-hydroxypropyl)-7-methoxy-4 methyl coumarin (3). The structures were determined by spectroscopic methods, mainly 1D- and 2D-NMR. In vitro cytotoxicity was evaluated by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay. The results of cytotoxicity depending on their structure features showed that compound 3 had high activity on different cell lines, while compound 1 showed no activity against HCT116. Compound 2 had high activity towards HCT116 cell line.
Acknowledgment
The authors are thankful to the Bioassay-Cell Culture Laboratory, National Research Centre, El-Tahrir St., Dokki, Cairo 12622, Egypt, for conducting the analysis and determining the results of biology.
Conflict of interest statement: The authors declare no conflict of interest.
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Supplemental Material:
The online version of this article offers supplementary material (https://doi.org/10.1515/znc-2017-0068).
©2018 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Three new coumarin types from aerial parts of Ammi majus L. and their cytotoxic activity
- Sesquiterpenes from the Saudi Red Sea: Litophyton arboreum with their cytotoxic and antimicrobial activities
- Biotechnology for bioenergy dedicated trees: meeting future energy demands
- Malusides, novel glucosylceramides isolated from apple pomace (Malus domestica)
- GC-MS characterization of n-hexane soluble fraction from dandelion (Taraxacum officinale Weber ex F.H. Wigg.) aerial parts and its antioxidant and antimicrobial properties
- N-Acetylborrelidin B: a new bioactive metabolite from Streptomyces mutabilis sp. MII
- Synthesis of methyl 4-dihydrotrisporate B and methyl trisporate B, morphogenetic factors of Zygomycetes fungi
- Volatiles from Cinnamomum cassia buds
- A new method for fast extraction and determination of chlorophylls in natural water
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Artikel in diesem Heft
- Frontmatter
- Three new coumarin types from aerial parts of Ammi majus L. and their cytotoxic activity
- Sesquiterpenes from the Saudi Red Sea: Litophyton arboreum with their cytotoxic and antimicrobial activities
- Biotechnology for bioenergy dedicated trees: meeting future energy demands
- Malusides, novel glucosylceramides isolated from apple pomace (Malus domestica)
- GC-MS characterization of n-hexane soluble fraction from dandelion (Taraxacum officinale Weber ex F.H. Wigg.) aerial parts and its antioxidant and antimicrobial properties
- N-Acetylborrelidin B: a new bioactive metabolite from Streptomyces mutabilis sp. MII
- Synthesis of methyl 4-dihydrotrisporate B and methyl trisporate B, morphogenetic factors of Zygomycetes fungi
- Volatiles from Cinnamomum cassia buds
- A new method for fast extraction and determination of chlorophylls in natural water
- Synthesis and biological evaluation of acyl derivatives of hydroxyflavones as potent antiproliferative agents against drug resistance cell lines
