Development of cream to enhance the antifungal activity and reduce the side effects of fluconazole for the treatment of Candida albicans
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Navya Ajitkumar Bhaskaran
,
Ruchi Verma
Abstract
The aim of the present study was to formulate a fluconazole cream for the treatment of Candida albicans. The optimized cream formulation was prepared using stearic acid, oleic acid, beeswax and borax. The uniform distribution of the active ingredient fluconazole could be confirmed in all formulated creams. The FC-C-C formulation showed satisfactory spreadability and extrudability. FC-C-C delivered (95.07 ± 15.85)% in only 36 h, and the formulation released the drug by an anomalous diffusion mechanism. The viscosity of FC-C-C was found to be (63.20 ± 0.83) cP. The antifungal study and animal studies confirmed that the prepared formulation is non-irritant and has an enhanced antifungal activity that reduces the side effects of fluconazole. The studies confirm that the prepared formulation may be useful for the treatment of Candida albicans.
Acknowledgements
Authors are thankful to Ipca Laboratories, Mumbai, India for providing drug as a gift sample. Authors also acknowledge the support of Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India for providing infrastructural facilities.
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Author contributions: Authors contributed equally.
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Research funding: None declared.
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Conflict of interest statement: The authors declared that there is no conflict of interest in this work.
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© 2022 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Review Article
- What science knows about our daily dishwashing routine
- Detergent Ingredients
- Effect of sodium lignosulfonate on the anti-redeposition ability of cotton cloth in a SDBS-Na2C2O4-CMC formulation
- Application
- Development of cream to enhance the antifungal activity and reduce the side effects of fluconazole for the treatment of Candida albicans
- Physical Chemistry
- Sodium dodecyl benzene sulfonate (SDBS) and N,N-dimethyldodecan-1-amine oxide (DDAO) in single and mixed systems as corrosion inhibitors of zinc in hydrochloric acid
- Novel Surfactants
- Study on the synthesis and performance of sodium 2-laurylamido isobutyrate
- Surfactant Analysis
- Determination of degree of ethoxylation of fatty alcohol ethoxylates by FTIR/ATR spectroscopy and multivalibrate calibration
- Flotation
- Increased effectiveness of the flotation separation of hornblende and magnesite by adding citric acid as depressant
Artikel in diesem Heft
- Frontmatter
- Review Article
- What science knows about our daily dishwashing routine
- Detergent Ingredients
- Effect of sodium lignosulfonate on the anti-redeposition ability of cotton cloth in a SDBS-Na2C2O4-CMC formulation
- Application
- Development of cream to enhance the antifungal activity and reduce the side effects of fluconazole for the treatment of Candida albicans
- Physical Chemistry
- Sodium dodecyl benzene sulfonate (SDBS) and N,N-dimethyldodecan-1-amine oxide (DDAO) in single and mixed systems as corrosion inhibitors of zinc in hydrochloric acid
- Novel Surfactants
- Study on the synthesis and performance of sodium 2-laurylamido isobutyrate
- Surfactant Analysis
- Determination of degree of ethoxylation of fatty alcohol ethoxylates by FTIR/ATR spectroscopy and multivalibrate calibration
- Flotation
- Increased effectiveness of the flotation separation of hornblende and magnesite by adding citric acid as depressant
