5-HT1A receptor as a key player in the brain 5-HT system
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Nina K. Popova
Nina K. Popova, D.Sci., Professor, Honored Scientist of Russia, Head of the Laboratory of Behavioral Neurogenomics at the Institute of Cytology and Genetics, Siberian Branch of Russia Academy of Sciences, Novosibirsk, Russia. N.K. Popova has authored over 300 articles published in Russian and international neuroscience journals. She is a member of the Russian Physiological Society, Vavilov Society of Geneticists, and the International Behavioral and Neural Genetics Society and Serotonin Club. Her main interests are neurophysiology, neurogenomics, and behavior. Her laboratory specializes in the role of brain neurotransmitters (mainly serotonin) in genetically defined normal and pathological behavior (aggression, catalepsy, anxiety, depression) in both animals and humans.
Vladimir S. Naumenko graduated from Novosibirsk State University in 2005. He became a researcher at the Department of Behavioral Neurogenomics at the Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Novosibirsk, Russia. In 2006, he made his PhD thesis and in 2012 defended his D.Sci. thesis. Now he investigates the role of the brain neurotransmitter systems in the regulation of brain function and different kinds of behavior. V.S. Naumenko is a member of the Russian Physiological Society and International Behavioral and Neural Genetics Society. He is the author and co-author of more than 37 papers in peer-reviewed journals.
Abstract
Among an impressive variety of identified serotonin receptors, 5-HT1A attracts particular attention due to its central role in the regulation of 5-HT-ergic neurotransmission and the data on its involvement in the mechanisms of stress response, aggressive behavior, anxiety, and depression. This review concentrates on the cross-regulation between 5-HT receptors and the implication of the 5-HT1A receptor in the genetic control of 5-HT-related behavior. Specifically, it describes the (1) functional interactions between 5-HT1A, 5-HT2A, 5-HT3, and 5-HT7 receptors; (2) cross-talk between 5-HT1A receptor and genes encoding key members of the brain 5-HT system; (3) implication of the 5-HT1A receptor in natural hibernation and genetic predisposition to different kinds of defensive behavior; and (4) role of 5-HT1A autoreceptors and heteroreceptors in anxiety, depression, and suicide, and in the antidepressant effect of serotonin reuptake inhibitors. This review provides converging lines of evidence that the 5-HT1A receptor contributes to the action of other 5-HT receptors, modulating their effect on behavior, and describes new data on the unique role of the 5-HT1A receptor in the indirect regulation of gene expression and in the autoregulation of the brain 5-HT system.
About the authors
Nina K. Popova, D.Sci., Professor, Honored Scientist of Russia, Head of the Laboratory of Behavioral Neurogenomics at the Institute of Cytology and Genetics, Siberian Branch of Russia Academy of Sciences, Novosibirsk, Russia. N.K. Popova has authored over 300 articles published in Russian and international neuroscience journals. She is a member of the Russian Physiological Society, Vavilov Society of Geneticists, and the International Behavioral and Neural Genetics Society and Serotonin Club. Her main interests are neurophysiology, neurogenomics, and behavior. Her laboratory specializes in the role of brain neurotransmitters (mainly serotonin) in genetically defined normal and pathological behavior (aggression, catalepsy, anxiety, depression) in both animals and humans.
Vladimir S. Naumenko graduated from Novosibirsk State University in 2005. He became a researcher at the Department of Behavioral Neurogenomics at the Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Novosibirsk, Russia. In 2006, he made his PhD thesis and in 2012 defended his D.Sci. thesis. Now he investigates the role of the brain neurotransmitter systems in the regulation of brain function and different kinds of behavior. V.S. Naumenko is a member of the Russian Physiological Society and International Behavioral and Neural Genetics Society. He is the author and co-author of more than 37 papers in peer-reviewed journals.
©2013 by Walter de Gruyter Berlin Boston
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Artikel in diesem Heft
- Masthead
- Masthead
- The role of Ser129 phosphorylation of α-synuclein in neurodegeneration of Parkinson’s disease: a review of in vivo models
- The role of the subthalamic nucleus in cognition
- Physical exercise and Parkinson’s disease: influence on symptoms, disease course and prevention
- The role of serotonin in the antidyskinetic effects of deep brain stimulation: focus on antipsychotic-induced motor symptoms
- Imaging the structure of the human anxious brain: a review of findings from neuroscientific personality psychology
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- Red/near-infrared irradiation therapy for treatment of central nervous system injuries and disorders
- Effects of chronic stress on the auditory system and fear learning: an evolutionary approach
