Silver impregnated nanoparticles of titanium dioxide as carriers for 211At
-
Edyta Cedrowska
,
Monika Łyczko
Abstract
The 211At radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately use of 211At is limited, because astatine as the heaviest halogen forms weak bond with carbon atoms in the biomolecules which makes 211At bioconjugates unstable in physiological conditions. In our work we propose a new solution for binding of 211At which consists of using nanoparticles of titanium dioxide modified with silver atoms as carriers for 211At. Ag+ cations have been absorbed on the nanometer-sized TiO2 particles (15 and 32 nm) through ion exchange process and were reduced in Tollens' reaction. The obtained TiO2-Ag nanoparticles were labeled with 211At. It was found that labeling yields were almost quantitative under reducing conditions, while under oxidizing conditions they dropped to about 80%. The labeled nanoparticles exhibited very high stability in physiological salt, PBS buffer, solutions of peptides (0.001 M cysteine, 0.001 M glutathione) and in human blood serum. To make TiO2/Ag nanoparticles well dispersed in water and biocompatible their surface was modified with a silane coupling agent containing poly(ethyleneglycol) molecules. The developed functionalization approach will allow us to attach biomolecules to the TiO2/Ag surface.
Acknowledgement
The authors express their thanks to Professor Wiktor Zipper, Institute of Physics, University of Silesia, Doctor Jarosław Choiński, dept. techn. director of HIL and Professor Jerzy Jastrzębski, spokesperson of the 211At production project for their interest and involvement in this work. Our sincere thanks are due to the Warsaw Cyclotron technical and operating team under the supervision of Przemysław Gmaj for the numerous irradiation of Bi samples. This work was supported by National Science Center of Poland (grant 2011/01/M/ST4/06756 and grant 2013/11/B/ST4/00516). We thank Professor S. Siekierski for helpful discussions and comments.
©2015 Walter de Gruyter Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Proton induced nuclear reactions on natural antimony up to 17 MeV
- Co-extraction and co-stripping of U(VI) and Pu(IV) using tri-iso-amyl phosphate and tri-n-butyl phosphate in n-dodecane from nitric acid media under high loading conditions
- Application of response surface methodology to optimize uranium biological leaching at high pulp density
- Development of a Ga-68 labeled triptorelin analog for GnRH receptor imaging
- Preparation and performance of 99Mo/99mTc chromatographic column generator based on zirconium molybdosilicate
- Silver impregnated nanoparticles of titanium dioxide as carriers for 211At
- Modification of chemical, optical and structural properties of Bayfol CR-6-2 using gamma and neutron irradiation
- Instrumental neutron activation analysis of Marrubium vulgare L., a valuable medicinal herb
Artikel in diesem Heft
- Frontmatter
- Proton induced nuclear reactions on natural antimony up to 17 MeV
- Co-extraction and co-stripping of U(VI) and Pu(IV) using tri-iso-amyl phosphate and tri-n-butyl phosphate in n-dodecane from nitric acid media under high loading conditions
- Application of response surface methodology to optimize uranium biological leaching at high pulp density
- Development of a Ga-68 labeled triptorelin analog for GnRH receptor imaging
- Preparation and performance of 99Mo/99mTc chromatographic column generator based on zirconium molybdosilicate
- Silver impregnated nanoparticles of titanium dioxide as carriers for 211At
- Modification of chemical, optical and structural properties of Bayfol CR-6-2 using gamma and neutron irradiation
- Instrumental neutron activation analysis of Marrubium vulgare L., a valuable medicinal herb
