Startseite Antioxidant metal oxide nanozymes: role in cellular redox homeostasis and therapeutics
Artikel
Lizenziert
Nicht lizenziert Erfordert eine Authentifizierung

Antioxidant metal oxide nanozymes: role in cellular redox homeostasis and therapeutics

  • Namrata Singh ORCID logo EMAIL logo
Veröffentlicht/Copyright: 3. November 2020

Abstract

Nanomaterials with enzyme-like activity, generally referred to as ‘nanozymes’, find myriad potential in various biomedical fields. More importantly, the nanoparticles that can functionally mimic the activity of cellular antioxidant enzymes attract tremendous interest owing to their possible therapeutic candidature in oxidative stress-mediated disorders. Oxidative stress culminating due to excess reactive oxygen species (ROS) level and dysregulated cellular antioxidant machinery is implicated in the development and progression of various pathophysiological disorders such as cancer, diabetes, cardiovascular and neurodegenerative diseases. Moreover, the optimum essentiality of ROS due to its pivotal role in cell signaling evokes the requirement of novel artificial antioxidant enzymes that can circumvent the detrimental effects of enhanced ROS levels without perturbing the basal redox status of cells. In recent years, the fast emanating artificial enzymes, i.e. nanozymes with antioxidant enzyme-like activity, has made tremendous progress with their broad applications in therapeutics, diagnostic medicine, bio-sensing, and immunoassay. Among various antioxidant nanoparticles reported till-date, the metal oxide nanozymes have emerged as the most efficient and successful candidates in mimicking the activity of first-line defense antioxidant enzymes, i.e. superoxide dismutase, catalase, and glutathione peroxidase. This review intends to exclusively highlight the development of representative metal oxide-based antioxidant nanozymes capable of maintaining the cellular redox homeostasis and their potential therapeutic significance.


Article note:

A collection of peer-reviewed articles by the winners of the 2020 IUPAC-Solvay International Award for Young Chemists.



Corresponding author: Namrata Singh, Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India, e-mail:

Acknowledgment

I would like to express my sincere gratitude to Prof. G. Mugesh for his guidance and constant support during my graduate studies. I thank Prof. G. Mugesh, Dr. P. Prakash, Dr. Geethika. M and Prof. V. Venkatesh, for their critical inputs and comments in the preparation of this manuscript. N. S. thanks Pure and Applied Chemistry for the invitation to author this review. N.S. is currently a Postdoctoral fellow with Prof. Molly Stevens at Imperial College London.

References

[1] V. J. Thannickal, B. L. Fanburg. Am. J. Physiol. Lung Cell Mol. Physiol. 279, L1005 (2000).10.1152/ajplung.2000.279.6.L1005Suche in Google Scholar PubMed

[2] P. D. Ray, B. Huang, Y. Tsuji. Cell Signal. 24, 981 (2012).10.1016/j.cellsig.2012.01.008Suche in Google Scholar PubMed PubMed Central

[3] T. Finkel. J. Cell Biol. 194, 7 (2011).10.1083/jcb.201102095Suche in Google Scholar PubMed PubMed Central

[4] B. D. Autreaux, M. B. Toledano. Nat. Rev. Mol. Cell Biol. 8, 813 (2007).10.1038/nrm2256Suche in Google Scholar PubMed

[5] M. D. Brand. Exp. Gerontol. 45, 466 (2010).10.1016/j.exger.2010.01.003Suche in Google Scholar PubMed PubMed Central

[6] J. D. Lambeth. Nat. Rev. Immunol. 4, 181 (2004).10.1038/nri1312Suche in Google Scholar PubMed

[7] N. Cantu-Medellin, E. E Kelley. Redox Biol. 1, 353 (2013).10.1016/j.redox.2013.05.002Suche in Google Scholar PubMed PubMed Central

[8] A. M. Pisoschi, A. Pop. Eur. J. Med. Chem. 97, 55 (2015).10.1016/j.ejmech.2015.04.040Suche in Google Scholar PubMed

[9] J. M. Mates. Toxicology 153, 83 (2000).10.1016/S0300-483X(00)00306-1Suche in Google Scholar

[10] H. Sies. Exp. Physiol. 82, 291 (1997).10.1113/expphysiol.1997.sp004024Suche in Google Scholar PubMed

[11] C. Michiels, M. Raes, O. Toussaint, J. Remacle. Free Radic. Biol. Med. 17, 235 (1994).10.1016/0891-5849(94)90079-5Suche in Google Scholar PubMed

[12] L. He, T. He, S. Farrar, L. Ji, T. Liu, X. Ma. Cell. Physiol. Biochem. 44, 532 (2017).10.1159/000485089Suche in Google Scholar PubMed

[13] J. M. McCord, B. B. KeeleJr., I. Fridovich. Proc. Natl. Acad. Sci. U. S. A. 68, 1024 (1971).10.1073/pnas.68.5.1024Suche in Google Scholar PubMed PubMed Central

[14] J. Azadmanesh, G. E. O. Borgstahl. Antioxidants (Basel) 7, 25 (2018).10.3390/antiox7020025Suche in Google Scholar PubMed PubMed Central

[15] J. R. Arthur. Cell Mol. Life Sci. 57, 1825 (2000).10.1007/PL00000664Suche in Google Scholar PubMed PubMed Central

[16] E. E. Battin, J. L. Brumaghim. Cell Biochem. Biophys. 55, 1 (2009).10.1007/s12013-009-9054-7Suche in Google Scholar PubMed

[17] S. G. Rhee, K.-S. Yang, S. W. Kang, H. A. Woo, T.-S. Chang. Antioxid. Redox Signal. 7, 619 (2005).10.1089/ars.2005.7.619Suche in Google Scholar PubMed

[18] D. P. Jones, Y. M. Go. Curr. Opin. Chem. Biol. 15, 103 (2011).10.1016/j.cbpa.2010.12.014Suche in Google Scholar PubMed

[19] A. Holmgren. J. Biol. Chem. 264, 13963 (1989).10.1016/S0021-9258(18)71625-6Suche in Google Scholar

[20] A. Rahal, A. Kumar, V. Singh, B. Yadav, R. Tiwari, S. Chakraborty, K. Dhama. Biomed. Res. Int. 2014, 761264 (2014).10.1155/2014/761264Suche in Google Scholar PubMed PubMed Central

[21] H. Sies, C. Berndt, D. P. Jones. Annu. Rev. Biochem. 86, 715 (2017).10.1146/annurev-biochem-061516-045037Suche in Google Scholar PubMed

[22] H. Sies. Angew. Chem. Int. Ed. Engl. 25, 1058 (1986).10.1002/anie.198610581Suche in Google Scholar

[23] J. A. Imlay. Annu. Rev. Microbiol. 57, 395 (2003).10.1146/annurev.micro.57.030502.090938Suche in Google Scholar PubMed

[24] A. J. Kowaltowski, A. E. Vercesi. Free Radic. Biol. Med. 26, 463 (1999).10.1016/S0891-5849(98)00216-0Suche in Google Scholar PubMed

[25] J. A. Imlay, S. Linn. Science 240, 1302 (1988).10.1126/science.3287616Suche in Google Scholar PubMed

[26] R. A. Floyd, J. M. Carney. Ann. Neurol. 32, S22 (1992).10.1002/ana.410320706Suche in Google Scholar PubMed

[27] I. Dalle-Donne, G. Aldini, M. Carini, R. Colombo, R. Rossi, A. Milzani. J. Cell. Mol. Med. 10, 389 (2006).10.1111/j.1582-4934.2006.tb00407.xSuche in Google Scholar PubMed PubMed Central

[28] K. J. Davies. J. Biol. Chem. 262, 9895 (1987).10.1016/S0021-9258(18)48018-0Suche in Google Scholar

[29] D. Harrison, K. K. Griendling, U. Landmesser, B. Hornig, H. Drexler. Am. J. Cardiol. 91, 7 (2003).10.1016/S0002-9149(02)03144-2Suche in Google Scholar

[30] K. J. Barnham, C. L. Masters, A. I. Bush. Nat. Rev. Drug Discov. 3, 205 (2004).10.1038/nrd1330Suche in Google Scholar PubMed

[31] W. R. Markesberya. Free Radical Biol. Med. 23, 134 (1997).10.1016/S0891-5849(96)00629-6Suche in Google Scholar

[32] M. Nishikawa. Cancer Lett. 266, 53 (2008).10.1016/j.canlet.2008.02.031Suche in Google Scholar PubMed

[33] J. W. Baynes. Diabetes 40, 405 (1991).10.2337/diab.40.4.405Suche in Google Scholar PubMed

[34] A. Terman, U. T. Brunk. Antioxid. Redox Signal. 8, 197 (2006).10.1089/ars.2006.8.197Suche in Google Scholar PubMed

[35] T. Finkel, N. J. Holbrook. Nature 408, 239 (2000).10.1038/35041687Suche in Google Scholar PubMed

[36] T. Fukai, M. Ushio-Fukai. Antioxid. Redox Signal. 15, 1583 (2011).10.1089/ars.2011.3999Suche in Google Scholar PubMed PubMed Central

[37] D. L. Marcus, C. Thomas, C. Rodriguez, K. Simberkoff, J. S. Tsai, J. A. Strafaci, M. L. Freedman. Exp. Neurol. 150, 40 (1998).10.1006/exnr.1997.6750Suche in Google Scholar PubMed

[38] Y.-H. Wei, H.-C. Lee. Exp. Biol. Med. 227, 671 (2002).10.1177/153537020222700901Suche in Google Scholar PubMed

[39] J. S. Beckman, M. Carson, C. D. Smith, W. H. Koppenol. Nature 364, 584 (1993).10.1038/364584a0Suche in Google Scholar PubMed

[40] U. Kumari, W. Y. Jun, B. H. Bay, A. Lyakhovich. Oncogene 33, 165 (2014).10.1038/onc.2012.583Suche in Google Scholar PubMed

[41] R. Breslow. Acc. Chem. Res. 28, 146 (1995).10.1021/ar00051a008Suche in Google Scholar

[42] D. Desbouis, I. P. Troitsky, M. J. Belousoff, L. Spiccia, B. Graham. Coord. Chem. Rev. 256, 897 (2012).10.1016/j.ccr.2011.12.005Suche in Google Scholar

[43] G. Mugesh, H. B. Singh. Chem. Soc. Rev. 29, 347 (2000).10.1039/a908114cSuche in Google Scholar

[44] K. P. Bhabak, G. Mugesh. Acc. Chem. Res. 43, 1408 (2010).10.1021/ar100059gSuche in Google Scholar PubMed

[45] X. Huang, X. M. Liu, Q. A. Luo, J. Q. Liu, J. C. Shen. Chem. Soc. Rev. 40, 1171 (2011).10.1039/C0CS00046ASuche in Google Scholar PubMed

[46] Y. Aiba, J. Sumaoka, M. Komiyama. Chem. Soc. Rev. 40, 5657 (2011).10.1039/c1cs15039aSuche in Google Scholar PubMed

[47] Y. Murakami, J. J. Kikuchi, Y. Hisaeda, O. Hayashida. Chem. Rev. 96, 721 (1996).10.1021/cr9403704Suche in Google Scholar PubMed

[48] D. P. Riley. Chem. Rev. 99, 2573 (1999).10.1021/cr980432gSuche in Google Scholar PubMed

[49] G. Wulff. Chem. Rev. 102, 1 (2002).10.1021/cr980039aSuche in Google Scholar PubMed

[50] G. Wulff, J. Q. Liu Acc. Chem. Res. 45, 239 (2012).10.1021/ar200146mSuche in Google Scholar PubMed

[51] R. Villalonga, R. Cao, A. Fragoso. Chem. Rev. 107, 3088 (2007).10.1021/cr050253gSuche in Google Scholar PubMed

[52] Z. Dong, Q. Luoa, J. Liu. Chem. Soc. Rev. 41, 7890 (2012).10.1039/c2cs35207aSuche in Google Scholar PubMed

[53] M. C. Feiters, A. E. Rowan, R. J. M. Nolte. Chem. Soc. Rev. 29, 375 (2000).10.1039/a804252gSuche in Google Scholar

[54] P. Molenveld, J. F. J. Engbersen, D. N. Reinhoudt. Chem. Soc. Rev. 29, 75 (2000).10.1039/a804295kSuche in Google Scholar

[55] C. M. Thomas, T. R. Ward. Chem. Soc. Rev. 34, 337 (2005).10.1039/b314695mSuche in Google Scholar PubMed

[56] T. Darbre, J.-L. Reymond. Acc. Chem. Res. 39, 925 (2006).10.1021/ar050203ySuche in Google Scholar PubMed

[57] F. Gloaguen, T. B. Rauchfuss. Chem. Soc. Rev. 38, 100 (2009).10.1039/B801796BSuche in Google Scholar

[58] S. Friedle, E. Reisner, S. J. Lippard. Chem. Soc. Rev. 39, 2768 (2010).10.1039/c003079cSuche in Google Scholar PubMed PubMed Central

[59] H. Wei, E. Wang. Chem. Soc. Rev. 42, 6060 (2013) and references therein.10.1039/c3cs35486eSuche in Google Scholar PubMed

[60] Y. H. Lin, J. S. Ren, X. G. Qu, Acc. Chem. Res. 47, 1097 (2014).10.1021/ar400250zSuche in Google Scholar PubMed

[61] X. Y. Wang, W. J. Guo, Y. H. Hu, J. J. Wu, H. Wei. Nanozymes: Next Wave of Artificial Enzymes, Berlin/Heidelberg, Springer (2016).10.1007/978-3-662-53068-9Suche in Google Scholar

[62] D. Pedone, M. Moglianetti, E. De Luca, G. Bardi, P. P. Pompa. Chem. Soc. Rev. 46, 4951 (2017).10.1039/C7CS00152ESuche in Google Scholar

[63] M. Liang, X. Yan. Acc. Chem. Res. 52, 2190 (2019).10.1021/acs.accounts.9b00140Suche in Google Scholar PubMed

[64] Y. Huang, J. Ren, X. Qu. Chem. Rev. 119, 4357 (2019).10.1021/acs.chemrev.8b00672Suche in Google Scholar PubMed

[65] J. Wu, X. Wang, Q. Wang, Z. Lou, S. Li, Y. Zhu, L. Qin, H. Wei. Chem. Soc. Rev. 48, 1004 (2019) and references therein.10.1039/C8CS00457ASuche in Google Scholar PubMed

[66] H. Wang, K. Wan, X. Shi. Adv. Mater. 31, 1805368 (2019).10.1002/adma.201805368Suche in Google Scholar PubMed

[67] D. Jiang, D. Ni, Z. T. Rosenkrans, P. Huang, X. Yan, W. Cai. Chem. Soc. Rev. 48, 3683 (2019).10.1039/C8CS00718GSuche in Google Scholar

[68] X. Wang, Y. Hu, H. Wei. Inorg. Chem. Front. 3, 41 (2016).10.1039/C5QI00240KSuche in Google Scholar

[69] M. De, P. S. Ghosh, V. M. Rotello. Adv. Mater. 20, 4225 (2008).10.1002/adma.200703183Suche in Google Scholar

[70] J. Gao, H. Gu, B. Xu. Acc. Chem. Res. 42, 1097 (2009).10.1021/ar9000026Suche in Google Scholar PubMed

[71] Y. Zhou, B. Liu, R. Yang, J. Liu. Bioconjugate Chem. 28, 2903 (2017).10.1021/acs.bioconjchem.7b00673Suche in Google Scholar PubMed

[72] L. Dykmana, N. Khlebtsov. Chem. Soc. Rev. 41, 2256 (2012).10.1039/C1CS15166ESuche in Google Scholar

[73] D. Kim, K. Shin, S. G. Kwon, T. Hyeon. Adv. Mater. 30, 1802309 (2018).10.1002/adma.201802309Suche in Google Scholar PubMed

[74] C. Walkey, S. Das, S. Seal, J. Erlichman, K. Heckman, L. Ghibelli, E. Traversa, J. F. McGinnis, W. T. Self. Environ. Sci. Nano 2, 33 (2015).10.1039/C4EN00138ASuche in Google Scholar PubMed PubMed Central

[75] M. Azharuddin, G. H. Zhu, D. Das, E. Ozgur, L. Uzun, A. P. F. Turner, H. K. Patra. Chem. Commun. 55, 6964 (2019).10.1039/C9CC01741KSuche in Google Scholar

[76] X. Liu, Y. Gao, R. Chandrawati, L. Hosta-Rigau. Nanoscale 11, 21046 (2019).10.1039/C9NR06596BSuche in Google Scholar PubMed

[77] X. Zhang, R. Huang, S. Gopalakrishnan, R. Cao-Milán, V. M. Rotello. Trends Chem. 1, 90 (2019).10.1016/j.trechm.2019.02.006Suche in Google Scholar PubMed PubMed Central

[78] W. Chen, S. Li, J. Wang, K. Sun, Y. Si. Nanoscale 11, 15783 (2019).10.1039/C9NR04771ASuche in Google Scholar PubMed

[79] C. P. Liu, T. H. Wu, C. Y. Liu, K. C. Chen, Y. X. Chen, G. S. Chen, S. Y. Lin. Small 13, 1700278 (2017).10.1002/smll.201700278Suche in Google Scholar

[80] H. Su, D. D. Liu, M. Zhao, W. L. Hu, S. S. Xue, Q. Cao, X. Y. Le, L. N. Ji, Z. W. Mao. ACS Appl. Mater. Interfaces 7, 8233 (2015).10.1021/acsami.5b01271Suche in Google Scholar PubMed

[81] S. Shibuya, Y. Ozawa, K. Watanabe, N. Izuo, T. Toda, K. Yokote, T. Shimizu. PLoS ONE 9, e109288 (2014).10.1371/journal.pone.0109288Suche in Google Scholar PubMed PubMed Central

[82] C. Wang, Q. Zhang, X. Wang, H. Chang, S. Zhang, Y. Tang, J. Xu, R. Qi, Y. Cheng. Angew. Chem. Int. Ed. 56, 6767 (2017).10.1002/anie.201700968Suche in Google Scholar PubMed

[83] Y. Yoshihisa, Q. L. Zhao, M. A. Hassan, Z. L. Wei, M. Furuichi, Y. Miyamoto, T. Kondo, T. Shimizu. Free Radic. Res. 45, 326 (2011).10.3109/10715762.2010.532494Suche in Google Scholar PubMed

[84] M. Takamiya, Y. Miyamoto, T. Yamashita, K. Deguchi, Y. Ohta, K. Abe. Neuroscience 221, 47 (2012).10.1016/j.neuroscience.2012.06.060Suche in Google Scholar PubMed

[85] M. Moglianetti, E. De Luca, D. Pedone, R. Marotta, T. Catelani, B. Sartori, H. Amenitsch, S. F. Retta, P. P. Pompa, Nanoscale 8, 3739 (2016).10.1039/C5NR08358CSuche in Google Scholar PubMed

[86] K. L. Fan, J. Q. Xi, L. Fan, P. X. Wang, C. H. Zhu, Y. Tang, X. D. Xu, M. M. Liang, B. Jiang, X. Y. Yan, L. Z. Gao. Nat. Commun. 9, 1440 (2018).10.1038/s41467-018-03903-8Suche in Google Scholar PubMed PubMed Central

[87] E. L. G. Samuel, D. C. Marcano, V. Berka, B. R. Bitner, G. Wu, A. Potter, R. H. Fabian, R. G. Pautler, T. A. Kent, A.-L. Tsai, J. M. Tour. Proc. Natl. Acad. Sci. U. S. A. 112, 2343 (2015).10.1073/pnas.1417047112Suche in Google Scholar PubMed PubMed Central

[88] S. S. Ali, J. I. Hardt, K. L. Quick, J. S. Kim-Han, B. F. Erlanger, T. T. Huang, C. J. Epstein, L. L. Dugan. Free Radic. Biol. Med. 37, 1191 (2004).10.1016/j.freeradbiomed.2004.07.002Suche in Google Scholar PubMed

[89] K. L. Quick, S. S. Ali, R. Arch, C. Xiong, D. Wozniak, L. L. Dugan. Neurobiol. Aging 29, 117 (2008).10.1016/j.neurobiolaging.2006.09.014Suche in Google Scholar PubMed

[90] N. Gao, K. Dong, A. D. Zhao, H. J. Sun, Y. Wang, J. S. Ren, X. G. Qu. Nano Res. 9, 1079 (2016).10.1007/s12274-016-1000-6Suche in Google Scholar

[91] H. Sun, Y. Zhou, J. Ren, X. Qu. Angew. Chem. Int. Ed. 57, 9224 (2018).10.1002/anie.201712469Suche in Google Scholar PubMed

[92] T. M. Chen, X. M. Tian, L. Huang, J. Xiao, G. W. Yang Nanoscale 9, 15673 (2017).10.1039/C7NR05629JSuche in Google Scholar

[93] W. Zhang, S. Hu, J. J. Yin, W. He, W. Lu, M. Ma, N. Gu, Y. Zhang J. Am. Chem. Soc. 138, 5860 (2016).10.1021/jacs.5b12070Suche in Google Scholar PubMed

[94] A. B. Fisher. Antioxid. Redox Signal. 11, 1349 (2009).10.1089/ars.2008.2378Suche in Google Scholar PubMed PubMed Central

[95] I. N. Zelko, T. J. Mariani, R. J. Folz. Free Radic. Biol. Med. 33, 337 (2002).10.1016/S0891-5849(02)00905-XSuche in Google Scholar

[96] G.-F. Liu, M. Filipovic, I. Ivanovic-Burmazovic, F. Beuerle, P. Witte, A. Hirsch. Angew. Chem. Int. Ed. 47, 3991 (2008).10.1002/anie.200800008Suche in Google Scholar PubMed

[97] A. S. Jalilov, L. G. Nilewski, V. Berka, C. Zhang, A. A. Yakovenko, G. Wu, T. A. Kent, A. L. Tsai, J. M. Tour. ACS Nano 11, 2024 (2017).10.1021/acsnano.6b08211Suche in Google Scholar PubMed PubMed Central

[98] X. M. Shen, W. Q. Liu, X. J. Gao, Z. H. Lu, X. C. Wu, X. F. Gao. J. Am. Chem. Soc. 137, 15882 (2015).10.1021/jacs.5b10346Suche in Google Scholar PubMed

[99] C. Korsvik, S. Patil, S. Seal, W. T. Self. Chem. Commun. 1056 (2007).10.1039/b615134eSuche in Google Scholar PubMed

[100] E. G. Heckert, A. S. Karakoti, S. Seal, W. T. Self. Biomaterials 29, 2705 (2008).10.1016/j.biomaterials.2008.03.014Suche in Google Scholar PubMed PubMed Central

[101] I. Celardo, M. De Nicola, C. Mandoli, J. Z. Pedersen, E. Traversa, L. Ghibelli. ACS Nano 5, 4537 (2011).10.1021/nn200126aSuche in Google Scholar PubMed

[102] A. Karakoti, S. Singh, J. M. Dowding, S. Seal, W. T. Self. Chem. Soc. Rev. 39, 4422 (2010).10.1039/b919677nSuche in Google Scholar PubMed

[103] C. K. Kim, T. Kim, I. Y. Choi, M. Soh, D. Kim, Y. J. Kim, H. Jang, H. S. Yang, J. Y. Kim, H. K. Park, S. P. Park, S. Park, T. Yu, B. W. Yoon, S. H. Lee, T. Hyeon. Angew. Chem. Int. Ed. 51, 11039 (2012).10.1002/anie.201203780Suche in Google Scholar PubMed

[104] K. L. Heckman, W. DeCoteau, A. Estevez, K. J. Reed, W. Costanzo, D. Sanford, J. C. Leiter, J. Clauss, K. Knapp, C. Gomez, P. Mullen, E. Rathbun, K. Prime, J. Marini, J. Patchefsky, A. S. Patchefsky, R. K. Hailstone, J. S. Erlichman. ACS Nano 7, 10582 (2013).10.1021/nn403743bSuche in Google Scholar PubMed

[105] H. J. Kwon, M.-Y. Cha, D. Kim, D. K. Kim, M. Soh, K. Shin, T. Hyeon, I. Mook-Jung. ACS Nano 10, 2860 (2016).10.1021/acsnano.5b08045Suche in Google Scholar PubMed

[106] R. W. Tarnuzzer, J. Colon, S. Patil, S. Seal. Nano Lett. 5, 2573 (2005).10.1021/nl052024fSuche in Google Scholar PubMed

[107] S. M. Hirst, A. S. Karakoti, R. D. Tyler, N. Sriranganathan, S. Seal, C. M. Reilly. Small 5, 2848 (2009).10.1002/smll.200901048Suche in Google Scholar PubMed

[108] X. Y. Liu, W. Wei, Q. Yuan, X. Zhang, N. Li, Y. G. Du, G. H. Ma, C. H. Yan, D. Ma. Chem. Commun. 48, 3155 (2012).10.1039/C1CC15815ESuche in Google Scholar

[109] J. P. Chen, S. Patil, S. Seal, J. F. McGinnis. Nat. Nanotechnol. 1, 142 (2006).10.1038/nnano.2006.91Suche in Google Scholar PubMed

[110] F. Zeng, Y. Wu, X. Li, X. Ge, Q. Guo, X. Lou, Z. Cao, B. Hu, N. J. Long, Y. Mao, C. Li. Angew. Chem. Int. Ed. 57, 5808 (2018).10.1002/anie.201802309Suche in Google Scholar PubMed

[111] Y. J. Guan, M. Li, K. Dong, N. Gao, J. S. Ren, Y. C. Zheng, X. G. Qu. Biomaterials 98, 92 (2016).10.1016/j.biomaterials.2016.05.005Suche in Google Scholar PubMed

[112] R. Ragg, A. M. Schilmann, K. Korschelt, C. Wieseotte, M. Kluenker, M. Viel, L. Voelker, S. Preiss, J. Herzberger, H. Frey, K. Heinze, P. Bluemler, M. N. Tahir, F. Natalio, W. Tremel. J. Mater. Chem. B 4, 7423 (2016).10.1039/C6TB02078JSuche in Google Scholar PubMed

[113] J. S. Mu, X. Zhao, J. Li, E. C. Yang, X. J. Zhao. J. Mater. Chem. B 4, 5217 (2016).10.1039/C6TB01390BSuche in Google Scholar

[114] C. Guo, L. Sun, X. Chen, D. Zhang. Neural. Regen. Res. 8, 2003 (2013).10.4103/1673-5374.112844Suche in Google Scholar

[115] D. B. Zorov, M. Juhaszova, S. J. Sollott. Physiol. Rev. 94, 909 (2014).10.1152/physrev.00026.2013Suche in Google Scholar PubMed PubMed Central

[116] S. Srinivasan, N. G. Avadhani. Free Radic. Biol. Med. 53, 1252 (2012).10.1016/j.freeradbiomed.2012.07.021Suche in Google Scholar PubMed PubMed Central

[117] M. K. F. Wikstrom. Nature 266, 271 (1997).10.1038/266271a0Suche in Google Scholar PubMed

[118] F. Fontanesi, I. C. Soto, D. Horn, A. Barrientos. Am. J. Physiol. Cell Physiol. 291, C1129 (2006).10.1152/ajpcell.00233.2006Suche in Google Scholar PubMed

[119] R. E. Davis, S. Miller, C. Herrnstadt, S. S. Ghosh, E. Fahy, L. A. Shinobu, D. Galasko, L. J. Thal, M. F. Beal, N. Howell, W. D. ParkerJr. Proc. Natl. Acad. Sci. U. S. A. 94, 4526 (1997).10.1073/pnas.94.9.4526Suche in Google Scholar PubMed PubMed Central

[120] D. C. Wallace. Science 256, 628 (1992).10.1126/science.1533953Suche in Google Scholar PubMed

[121] E. M. Mutisya, A. C. Bowling, M. F. Beal. J. Neurochem. 63, 2179 (1994).10.1046/j.1471-4159.1994.63062179.xSuche in Google Scholar PubMed

[122] M. F. Beal. Ann. Neurol. 58, 495 (2005).10.1002/ana.20624Suche in Google Scholar PubMed

[123] G. Zsurka, W. S. Kunz. Lancet Neurol. 14, 956 (2015).10.1016/S1474-4422(15)00148-9Suche in Google Scholar PubMed

[124] N. Singh, G. Mugesh. Angew. Chem. Int. Ed. 58, 7797 (2019).10.1002/anie.201903427Suche in Google Scholar PubMed

[125] B. Halliwell, J. M. C. Gutteridge. Biochem J. 219, 1 (1984).10.1042/bj2190001Suche in Google Scholar PubMed PubMed Central

[126] A. Deisseroth, A. L. Dounce. Physiol. Rev. 50, 319 (1970).10.1152/physrev.1970.50.3.319Suche in Google Scholar PubMed

[127] L. Góth, P. Rass, A. Páy. CNS Drugs 8, 141 (2004).10.1007/BF03260057Suche in Google Scholar PubMed

[128] T. Pirmohamed, J. M. Dowding, S. Singh, B. Wasserman, E. Heckert, A. S. Karakoti, J. E. S. King, S. Seal, W. T. Self, Chem. Commun. 46, 2736 (2010).10.1039/b922024kSuche in Google Scholar PubMed PubMed Central

[129] M. Y. Kim, J. Kim. ACS Biomater. Sci. Eng. 3, 572 (2017).10.1021/acsbiomaterials.6b00716Suche in Google Scholar PubMed

[130] Y. Zhang, Z. Y. Wang, X. J. Li, L. Wang, M. Yin, L. H. Wang, N. Chen, C. H. Fan, H. Y. Song. Adv. Mater. 28, 1387 (2016).10.1002/adma.201503893Suche in Google Scholar PubMed

[131] R. A. Gatenby, R. J. A. Gillies. Nat. Rev. Cancer 8, 56 (2008).10.1038/nrc2255Suche in Google Scholar PubMed

[132] S. Rockwell, I. T. Dobrucki, E. Y. Kim, S. T. Marrison, V. T. Vu. Curr. Mol. Med. 9, 442 (2009).10.2174/156652409788167087Suche in Google Scholar PubMed PubMed Central

[133] M. López-Lázaro. Cancer Lett. 252, 1 (2007).10.1016/j.canlet.2006.10.029Suche in Google Scholar PubMed

[134] P. Prasad, C. R. Gordijo, A. Z. Abbasi, A. Maeda, A. Ip, A. M. Rauth, R. S. DaCosta, X. Y. Wu. ACS Nano 8, 3202 (2014).10.1021/nn405773rSuche in Google Scholar PubMed

[135] W. P. Fan, W. B. Bu, B. Shen, Q. J. He, Z. W. Cui, Y. Y. Liu, X. P. Zheng, K. L. Zhao, J. L. Shi. Adv. Mater. 27, 4155 (2015).10.1002/adma.201405141Suche in Google Scholar PubMed

[136] J. Kim, H. R. Cho, H. Jeon, D. Kim, C. Song, N. Lee, S. H. Choi, T. Hyeon. J. Am. Chem. Soc. 139, 10992 (2017).10.1021/jacs.7b05559Suche in Google Scholar PubMed

[137] W. Y. Zhen, Y. Liu, L. Lin, J. Bai, X. D. Jia, H. Y. Tian, X. Jiang. Angew. Chem. Int. Ed. 57, 10309 (2018).10.1002/anie.201804466Suche in Google Scholar PubMed

[138] J. R. Peng, M. L. Dong, B. Ran, W. T. Li, Y. Hao, Q. Yang, L. W. Tan, K. Shi, Z. Y. Qian. ACS Appl. Mater. Interfaces 9, 13875 (2017).10.1021/acsami.7b01365Suche in Google Scholar PubMed

[139] P. Zhu, Y. Chen, J. Shi. ACS Nano 12, 3780 (2018).10.1021/acsnano.8b00999Suche in Google Scholar PubMed

[140] S. Seeher, B. A. Carlson, A. C. Miniard, E. K. Wirth, Y. Mahdi, D. L. Hatfield, D. M. Driscoll, U. Schweizer. Biochem. J. 462, 67 (2014).10.1042/BJ20140423Suche in Google Scholar PubMed PubMed Central

[141] A. A. Vernekar, D. Sinha, S. Srivastava, P. U. Paramasivam, P. D’Silva, G. Mugesh. Nat. Commun. 5, 5301 (2014).10.1038/ncomms6301Suche in Google Scholar PubMed

[142] S. Ghosh, S. Prasad, G. Mugesh. Inorg. Chim. Acta 484, 283 (2019).10.1016/j.ica.2018.09.045Suche in Google Scholar

[143] S. Ghosh, P. Roy, N. Karmodak, E. D. Jemmis, G. Mugesh. Angew. Chem. Int. Ed. 57, 4510 (2018).10.1002/anie.201800681Suche in Google Scholar PubMed

[144] F. Pagliari, C. Mandoli, G. Forte, E. Magnani, S. Pagliari, G. Nardone, S. Licoccia, M. Minieri, P. Di Nardo, E. Traversa, ACS Nano 6, 3767 (2012).10.1021/nn2048069Suche in Google Scholar PubMed

[145] M. Soh, D. W. Kang, H. G. Jeong, D. Kim, D. Y. Kim, W. Yang, C. Song, S. Baik, I. Y. Choi, S. K. Ki, H. J. Kwon, T. Kim, C. K. Kim, S. H. Lee, T. Hyeon. Angew. Chem. Int. Ed. 56, 11399 (2017).10.1002/anie.201704904Suche in Google Scholar PubMed

[146] M. B. Kolli, N. D. P. K. Manne, R. Para, S. K. Nalabotu, G. Nandyala, T. Shokuhfar, K. He, A. Hamlekhan, J. Y. Ma, P. S. Wehner, L. Dornon, R. Arvapalli, K. M. Rice, E. R. Blough. Biomaterials 35, 9951 (2014).10.1016/j.biomaterials.2014.08.037Suche in Google Scholar PubMed PubMed Central

[147] L. Alili, M. Sack, C. von Montfort, S. Giri, S. Das, K. S. Carroll, K. Zanger, S. Seal, P. Brenneisen. Antioxid. Redox Signal. 19, 765 (2013).10.1089/ars.2012.4831Suche in Google Scholar PubMed PubMed Central

[148] H. J. Kwon, D. Kim, K. Seo, Y. G. kIm, S. I. Han, T. Kang, M. Soh, T. Hyeon. Angew. Chem. Int. Ed. 57, 9408 (2018).10.1002/anie.201805052Suche in Google Scholar PubMed

[149] Q. Q. Bao, P. Hu, Y. Y. Xu, T. S. Cheng, C. Y. Wei, L. M. Pan, J. L. Shi. ACS Nano 12, 6794 (2018).10.1021/acsnano.8b01994Suche in Google Scholar PubMed

[150] I. Celardo, J. Z. Pedersen, E. Traversa, L. Ghibelli. Nanoscale 3, 1411 (2011).10.1039/c0nr00875cSuche in Google Scholar PubMed

[151] Z. Wang, X. Shen, X. Gao, Y. Zhao. Nanoscale 11, 13289 (2019).10.1039/C9NR03473KSuche in Google Scholar

[152] J. L. Dong, L. N. Song, J. J. Yin, W. W. He, Y. H. Wu, N. Gu, Y. Zhang. Appl. Mater. Interfaces 6, 1959 (2014).10.1021/am405009fSuche in Google Scholar PubMed

[153] W. Li, Z. Liu, C. Liu, Y. Guan, J. Ren, X. Qu. Angew. Chem. Int. Ed. 56, 13661 (2017).10.1002/anie.201706910Suche in Google Scholar PubMed

[154] Y. Y. Huang, Z. Liu, C. Q. Liu, E. G. Ju, Y. Zhang, J. S. Ren, X. G. Qu. Angew. Chem. Int. Ed. 55, 6646 (2016).10.1002/anie.201600868Suche in Google Scholar PubMed

[155] N. Singh, M. A. Savanur, S. Srivastava, P. D’Silva, G. Mugesh. Angew. Chem. Int. Ed. 56, 14267 (2017).10.1002/anie.201708573Suche in Google Scholar PubMed

[156] N. Singh, M. Geethika, S. M. Eswarappa, G. Mugesh. Chem. Eur. J. 24, 8393 (2018).10.1002/chem.201800770Suche in Google Scholar PubMed

[157] N. Singh, M. A. Savanur, S. Srivastava, P. D’Silva, G. Mugesh. Nanoscale 11, 3855 (2019).10.1039/C8NR09397KSuche in Google Scholar

[158] S. Pfeiffer, A. Schrammel, D. Koesling, K. Schmidt, B. Mayer. Mol. Pharmacol. 53, 795 (1998).10.1124/mol.53.4.795Suche in Google Scholar PubMed

[159] M. A. Sharpe, R. Ollosson, V. C. Stewart, J. B. Clark. Biochem. J. 366, 97 (2002).10.1042/bj20020154Suche in Google Scholar

[160] J. M. Dowding, T. Dosani, A. Kumar, S. Seal, W. T. Self. Chem. Commun. 48, 4896 (2012).10.1039/c2cc30485fSuche in Google Scholar PubMed

[161] U. Forstermann, W. C. Sessa. Eur. Heart J. 33, 829 (2012).10.1093/eurheartj/ehr304Suche in Google Scholar PubMed PubMed Central

[162] R. F. Furchgott, J. V. Zawadzki. Nature 288, 373 (1980).10.1038/288373a0Suche in Google Scholar PubMed

[163] H. Li, S. Horke, U. Forstermann. Atherosclerosis 237, 208 (2014).10.1016/j.atherosclerosis.2014.09.001Suche in Google Scholar PubMed

[164] U. Forstermann, T. Munzel. Circulation 113, 1708 (2006).10.1161/CIRCULATIONAHA.105.602532Suche in Google Scholar

[165] U. Landmesser, S. Dikalov, S. R. Price, L. McCann, T. Fukai, S. M. Holland, W. E. Witch, D. G. Harrison. J. Clin. Invest. 111, 1201 (2003).10.1172/JCI200314172Suche in Google Scholar

[166] P. Pacher, J. S. Beckman, L. Liaudet. Physiol. Rev. 87, 315 (2007).10.1152/physrev.00029.2006Suche in Google Scholar PubMed PubMed Central

[167] J. S. Beckman, W. H. Koppenol. Am. J. Physiol. Cell Physiol. 271, C1424 (1996).10.1152/ajpcell.1996.271.5.C1424Suche in Google Scholar PubMed

[168] K. K. Griendling, D. Sorescu, M. Ushio-Fukai. Circ. Res. 86, 494 (2000).10.1161/01.RES.86.5.494Suche in Google Scholar

[169] J. Yao, Y. Cheng, M. Zhou, S. Zhao, S. C. Lin, X. Wang, J. J. X. Wu, S. R. Li, H. Wei. Chem. Sci. 9, 2927 (2018).10.1039/C7SC05476ASuche in Google Scholar PubMed PubMed Central

[170] M. Zhou, X. Wang, S. Lin, Y. Cheng, S. Zhao, J. Lin, Z. Fang, Z. Lou, L. Qin, H. Wei. Adv. Healthcare Mater. 9, 2000064 (2020).10.1002/adhm.202000064Suche in Google Scholar PubMed

[171] S. I. Han, S. Lee, M. G. Cho, J. M. Yoo, M. H. Oh, B. Jeong, D. Kim, O. K. Park, J. Kim, E. Namkoong, J. Jo, N. Lee, C. Lim, M. Soh, Y.‐E. Sung, J. Yoo, K. Park. T. Hyeon. Adv. Mater. 32, 2001566 (2020).10.1002/adma.202001566Suche in Google Scholar PubMed

Published Online: 2020-11-03
Published in Print: 2021-02-23

© 2020 IUPAC & De Gruyter. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. For more information, please visit: http://creativecommons.org/licenses/by-nc-nd/4.0/

Heruntergeladen am 5.11.2025 von https://www.degruyterbrill.com/document/doi/10.1515/pac-2020-0802/html
Button zum nach oben scrollen