Startseite Pharmacological and phytochemical screening of Palestinian traditional medicinal plants Erodium laciniatum and Lactuca orientalis
Artikel
Lizenziert
Nicht lizenziert Erfordert eine Authentifizierung

Pharmacological and phytochemical screening of Palestinian traditional medicinal plants Erodium laciniatum and Lactuca orientalis

  • Nidal Jaradat EMAIL logo , Motasem AlMasri , Abdel Naser Zaid und Dua’a Ghazi Othman
Veröffentlicht/Copyright: 1. September 2017

Abstract

Background: Various epidemiological studies showed that herbal remedies containing polyphenols may protect against various diseases such as cancers, vascular diseases and inflammatory pathologies. Currently, such groups of bioactive compounds have become a subject of many antimicrobials and antioxidant investigations. Accordingly, the current study aimed to conduct biological and phytochemical screening for two Palestinian traditional medicinal plants, Erodium laciniatum and Lactuca orientalis.

Methods: Current plants phytoconstituents and their antioxidant activities were evaluated by using standard phytochemical methods; meanwhile, antimicrobial activities were estimated by using several types of American Type Culture Collection and multidrug resistant clinical isolates by using agar diffusion well-variant, agar diffusion disc-variant and broth microdilution methods.

Results: Phytochemical screenings showed that L. orientalis and E. laciniatum contain mixtures of secondary and primary metabolites Moreover, total flavonoid, tannins and phenols content in E. laciniatum extract were higher than the L. orientalis extracts with almost the same antioxidant potentials. Additionally, both plants organic and aqueous extracts showed various potentials of antimicrobial activity

Conclusions: Overall, the studied species have a mixture of phytochemicals, flavonoids, phenols and tannins also have antioxidant and antimicrobial activities which approved their folk uses in treatments of infectious and Alzheimer diseases and simultaneously can be used as therapeutic agents in the pharmaceutical industries.

Acknowledgments

Authors acknowledge the kind assistance of Mohamad Arar, Fatima Hussein and Linda Esa.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

References

[1] Joshi DD. Herbal drugs and fingerprints: evidence based herbal drugs. USA: Springer, 2012.10.1007/978-81-322-0804-4Suche in Google Scholar

[2] Ford K. Exposing the dangers and true motivations of conventional medicine: a summary of the most commonly misdiagnosed illnesses of modern medicine. USA: Lulu Publishing Service, 2015.Suche in Google Scholar

[3] Patridge E, Gareiss P, Kinch MS, Hoyer D. An analysis of FDA-approved drugs: natural products and their derivatives. Drug Discov Today. 2015;21:204–7.10.1016/j.drudis.2015.01.009Suche in Google Scholar PubMed

[4] Vadhana P. Emergence of herbal antimicrobial drug resistance in clinical bacterial isolates. Pharm Anal Acta. 2015;2015:1–7.10.4172/2153-2435.1000434Suche in Google Scholar

[5] Santhosh RS, Suriyanarayanan B. Plants: a source for new antimycobacterial drugs. Planta Med. 2014;80:9–21.10.1055/s-0033-1350978Suche in Google Scholar PubMed

[6] Jaradat NA, Zaid AN, Abuzant A, Khalaf S, Abu-Hassan N. Phytochemical and biological properties of four Astragalus species commonly used in traditional Palestinian medicine. Eur J Integr Med. 2017;9:1–8.10.1016/j.eujim.2017.01.008Suche in Google Scholar

[7] Pandey KB, Rizvi SI. Markers of oxidative stress in erythrocytes and plasma during aging in humans. Oxid Med Cell Longev. 2010;3:2–12.10.4161/oxim.3.1.10476Suche in Google Scholar PubMed PubMed Central

[8] Rodgers J. Holy land, headlines from the holy land. USA: Springer, 2015:170–89.10.1057/9781137395139_9Suche in Google Scholar

[9] Djamali M, Brewer S, Breckle SW, Jackson ST. Climatic determinism in phytogeographic regionalization: a test from the Irano-Turanian region, SW and Central Asia. Flora-Morphology Distrib Funct Ecol Plants. 2012;207:237–49.10.1016/j.flora.2012.01.009Suche in Google Scholar

[10] Surmaghi MS, Amin YA, Mahmoodi Z. Survey of Iranian plants for saponins alkaloids flavonoids and tannins. IV. DARU J Pharm Sci. 1992;2:1–11.Suche in Google Scholar

[11] Oran SA. A list of flowering wild plants in Tafila Province, Jordan. Int J Biodivers Conserv. 2014;6:28–40.10.5897/IJBC2011.116Suche in Google Scholar

[12] Danin A. Distribution atlas of plants in the Flora Palaestina area. Jerusalem: Academy of Sciences, 2004.Suche in Google Scholar

[13] Ali-Shtayeh M, Jamous RM. Traditional arabic Palestinian herbal medicine, TAPHM. Palestine: BERC, 2008.Suche in Google Scholar

[14] Ediage E, Di Mavungu J, Scippo M, Schneider Y. Screening, identification and quantification of glucosinolates in black radish (Raphanus sativus L. niger) based dietary supplements using liquid chromatography coupled with a photodiode array and liquid chromatography-mass spectrometry. J Chromatogr A. 2011;1218:4395–405.10.1016/j.chroma.2011.05.012Suche in Google Scholar PubMed

[15] Jaradat NA, Shawahna R, Hussein F, Al-Lahham S. Analysis of the antioxidant potential in aerial parts of Trigonella arabica and Trigonella berythea grown widely in Palestine: a comparative study. Eur J Integr Med. 2016;8:623–30.10.1016/j.eujim.2016.04.004Suche in Google Scholar

[16] Trease G, Evans W. Pharmacognosy, 12 ed. London: Bailliere Tindall, 1983.Suche in Google Scholar

[17] Harborne A. Phytochemical methods a guide to modern techniques of plant analysis. United States: Springer Science & Business Media, 1998.Suche in Google Scholar

[18] Folin O, Denis W. A colorimetric method for the determination of phenols (and phenol derivatives) in urine. J Biol Chem. 1915;22:305–8.10.1016/S0021-9258(18)87648-7Suche in Google Scholar

[19] Cheung L, Cheung PC, Ooi VE. Antioxidant activity and total phenolics of edible mushroom extracts. Food Chem. 2003;81:249–55.10.1016/S0308-8146(02)00419-3Suche in Google Scholar

[20] Chang CC, Yang MH, Wen HM, Chern JC. Estimation of total flavonoid content in propolis by two complementary colorimetric methods. J Food Drug Anal. 2002;10:178–82.10.38212/2224-6614.2748Suche in Google Scholar

[21] Nugroho A, Kim M, Lee J, Kim J, Lee K, Choi J, et al. Polyphenol analysis and peroxynitrite scavenging effect of the extracts from eight Korean mountainous vegetable. Korean J Pharmacogn. 2011;42:38–45.Suche in Google Scholar

[22] Singh R, Sharma S, Sharma V. Comparative and quantitative analysis of antioxidant and scavenging potential of Indigofera tinctoria Linn. extracts. Eur J Integr Med. 2015;13:269–78.10.1016/S2095-4964(15)60183-2Suche in Google Scholar

[23] Kardel M, Taube F, Schulz H, Schütze W, Gierus M. Different approaches to evaluate tannin content and structure of selected plant extracts-review and new aspects. J Appl Bot Food Qual. 2013;86:16–25.Suche in Google Scholar

[24] Falahati M, Tabrizib NO, Jahaniani F. Anti dermatophyte activities of Eucalyptus camaldulensis in comparison with Griseofulvin. Iranian J Pharmacol Ther. 2005;4:80–3.Suche in Google Scholar

[25] Wikler MA. Performance standards for antimicrobial susceptibility testing: seventeenth informational supplement. USA: Clinical and Laboratory Standards Institute, 2007.Suche in Google Scholar

[26] Forbes BA, Sahm DF, Weissfeld AS. Study guide for Bailey & Scott’s diagnostic microbiology. United States: Mosby, 2007.Suche in Google Scholar

[27] Abualhasan M, Jaradata N, Abu-Hasanb N, Almasrib M. Bioactivity of viscum album extracts from olive and almond host plants in Palestine. Pharmacogn J. 2014;6:117–23.10.5530/pj.2014.2.7Suche in Google Scholar

[28] Klepser ME, Wolfe EJ, Jones RN, Nightingale CH, Pfaller MA. Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans. Antimicrob Agents Chemother. 1997;41:1392–5.10.1128/AAC.41.6.1392Suche in Google Scholar PubMed PubMed Central

[29] Velioglu Y, Mazza G, Gao L, Oomah B. Antioxidant activity and total phenolics in selected fruits, vegetables, and grain products. J Agric Food Chem. 1998;46:4113–7.10.1021/jf9801973Suche in Google Scholar

[30] Kim B, Kim J, Kim H, Heo M. Biological screening of 100 plant extracts for cosmetic use (II): anti‐oxidative activity and free radical scavenging activity. Int J Cosmet Sci. 1997;19:299–307.10.1111/j.1467-2494.1997.tb00194.xSuche in Google Scholar PubMed

[31] Vinson JA, Hao Y, Su X, Zubik L. Phenol antioxidant quantity and quality in foods: vegetables. J Agric Food Chem. 1998;46:3630–4.10.1021/jf980295oSuche in Google Scholar

[32] Gillman MW, Cupples LA, Gagnon D, Posner BM, Ellison RC, Castelli WP, et al. Protective effect of fruits and vegetables on development of stroke in men. Jama. 1995;273:1113–7.10.1001/jama.1995.03520380049034Suche in Google Scholar PubMed

[33] Ames BN, Gold LS, Willett WC. The causes and prevention of cancer. Proc Natl Acad Sci. 1995;92:5258–65.10.1073/pnas.92.12.5258Suche in Google Scholar

[34] Noguchi N, Niki E. Phenolic antioxidants:: a rationale for design and evaluation of novel antioxidant drug for atherosclerosis. Free Radic Biol Med. 2000;28:1538–46.10.1016/S0891-5849(00)00256-2Suche in Google Scholar PubMed

[35] Young I, Woodside J. Antioxidants in health and disease. J Clin Pathol. 2001;54:176–86.10.1136/jcp.54.3.176Suche in Google Scholar PubMed

[36] Halliwell B. The antioxidant paradox. The Lancet. 2000;355:1179–80.10.1016/S0140-6736(00)02075-4Suche in Google Scholar

[37] Testa A, Leonardis D, Spoto B, Sanguedolce MC, Parlongo RM, Pisano A, et al. A polymorphism in a major antioxidant gene (Kelch-like ECH-associated protein 1) predicts incident cardiovascular events in chronic kidney disease patients: an exploratory study. J Hypertens. 2016;34:928–34.10.1097/HJH.0000000000000878Suche in Google Scholar PubMed

[38] Kubben N, Zhang W, Wang L, Voss TC, Yang J, Qu J, et al. Repression of the antioxidant NRF2 pathway in premature aging. Cell. 2016;165:1361–74.10.1016/j.cell.2016.05.017Suche in Google Scholar PubMed PubMed Central

[39] Johnston PC, McCance DR, Holmes VA, Young IS, McGinty A. Placental antioxidant enzyme status and lipid peroxidation in pregnant women with type 1 diabetes: the effect of vitamin C and E supplementation. J Diabetes Complications. 2016;30:109–14.10.1016/j.jdiacomp.2015.10.001Suche in Google Scholar PubMed

[40] Limagne E, Thibaudin M, Chalons P, Végran F, Mignot G. Importance of immune system modulation in anti-inflammatory and antitumoral properties of resveratrol, a polyphenol of wine. J Int Soc Antioxid Nutr Health. 2016;3.10.18143/JISANH_v3i4_1322Suche in Google Scholar

[41] Kahn LH. One health and the politics of antimicrobial resistance. USA: JHU Press, 2016.10.1353/book.72122Suche in Google Scholar

[42] Dong K, Ju E, Gao N, Wang Z, Ren J, Qu X. Synergistic eradication of antibiotic-resistant bacteria based biofilms in vivo using a NIR-sensitive nanoplatform. Chem Commun. 2016;52:5312–5.10.1039/C6CC00774KSuche in Google Scholar PubMed

[43] Cushnie TT, Lamb AJ. Recent advances in understanding the antibacterial properties of flavonoids. Int J Antimicrob Agents. 2011;38:99–107.10.1016/j.ijantimicag.2011.02.014Suche in Google Scholar PubMed

[44] Asadi-Samani M, Kafash-Farkhad N, Azimi N, Fasihi A, Alinia-Ahandani E, Rafieian-Kopaei M. Medicinal plants with hepatoprotective activity in Iranian folk medicine. Asian Pac J Trop Biomed. 2015;5:146–57.10.1016/S2221-1691(15)30159-3Suche in Google Scholar

[45] Ahmad A, Kaleem M, Ahmed Z, Shafiq H. Therapeutic potential of flavonoids and their mechanism of action against microbial and viral infections-A review. Food Res Int. 2015;77:221–35.10.1016/j.foodres.2015.06.021Suche in Google Scholar

[46] Vidhani SI, Vyas VG, Parmar HJ, Bhalani VM, Hassan MM, Gaber A, et al. Evaluation of some chemical composition, minerals fatty acid profiles, antioxidant and antimicrobial activities of Tulsi (Ocimum sanctum) from India. Am J Food Sci Technol. 2016;4:52–7.Suche in Google Scholar

[47] Daglia M. Polyphenols as antimicrobial agents. Curr Opin Biotechnol. 2012;23:174–81.10.1016/j.copbio.2011.08.007Suche in Google Scholar PubMed

[48] Meda A, Lamien CE, Romito M, Millogo J, Nacoulma OG. Determination of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity. Food Chem. 2005;91:571–7.10.1016/j.foodchem.2004.10.006Suche in Google Scholar

[49] Tapas AR, Sakarkar D, Kakde R. Flavonoids as nutraceuticals: a review. Trop J Pharm Res. 2008;7:1089–99.10.4314/tjpr.v7i3.14693Suche in Google Scholar

[50] Marcucci MC. Propolis: chemical composition, biological properties and therapeutic activity. Apidologie. 1995;26:83–99.10.1051/apido:19950202Suche in Google Scholar

[51] Tripoli E, La Guardia M, Giammanco S, Di Majo D, Giammanco M. Citrus flavonoids: molecular structure, biological activity and nutritional properties: a review. Food Chem. 2007;104:466–79.10.1016/j.foodchem.2006.11.054Suche in Google Scholar

[52] Singh M, Kaur M, Silakari O. Flavones: an important scaffold for medicinal chemistry. Eur J Med Chem. 2014;84:206–339.10.1016/j.ejmech.2014.07.013Suche in Google Scholar PubMed

[53] Asif M. Chemistry and antioxidant activity of plants containing some phenolic compounds. Chem Int. 2015;1:35–52.Suche in Google Scholar

[54] Koirala N, Thuan NH, Ghimire GP, Van Thang D, Sohng JK. Methylation of flavonoids: chemical structures, bioactivities, progress and perspectives for biotechnological production. Enzyme Microb Technol. 2016;86:103–16.10.1016/j.enzmictec.2016.02.003Suche in Google Scholar PubMed

[55] Ismail T, Sestili P, Akhtar S. Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects. J Ethnopharmacol. 2012;143:397–405.10.1016/j.jep.2012.07.004Suche in Google Scholar PubMed

[56] Bouaziz M, Dhouib A, Loukil S, Boukhris M, Sayadi S. Polyphenols content, antioxidant and antimicrobial activities of extracts of some wild plants collected from the south of Tunisia. Afr J Biotechnol. 2009;8:7017–27.Suche in Google Scholar

Received: 2017-4-24
Accepted: 2017-6-28
Published Online: 2017-9-1

© 2018 Walter de Gruyter GmbH, Berlin/Boston

Heruntergeladen am 28.11.2025 von https://www.degruyterbrill.com/document/doi/10.1515/jcim-2017-0059/html
Button zum nach oben scrollen