Hypotensive property of Chenopodium ambrosioides in anesthetized normotensive rats
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Asmae Assaidi
Abstract
Background: The leaves of Chenopodium ambrosioides L. (Chenopodiaceae) are widely used in Moroccan traditional medicine to treat diabetes and hypertension. The goal of the present work is to investigate the hypotensive properties of different extract and fractions of the plant in anesthetized normotensive rats and to elucidate the mechanism underlying this effect.Methods: The hypotensive effect of aqueous extract (AqE) of the leaves of C. ambrosioides L., methanolic (MF), ethyl acetate (AcF), and aqueous (AqF) Soxhlet fractions, administrated intravenously, was evaluated in anesthetized rats. The recorded signals of blood pressure and heart rate were visualized and analyzed by using an acquisition card “National Instrument” and software Labview 6.1.Results: Intravenous administration of AqE of the leaves of C. ambrosioides L. induces a dose-dependent hypotension. A similar effect was obtained with MF, AcF, and AqF. Atropine (1 mg/kg), used to block cholinergic system, significantly reduced the hypotensive response to MF and AcF suggesting the presence of the cholinomimetic–muscarinic components in these fractions. However, the blood pressure lowering effect of MF and AcF in rats pretreated with L-NAME 20 mg/kg was unchanged showing that the release of NO is not implicated in the hypotensive action of this plant.Conclusions: The present study demonstrates that extracts from leaves of C. ambrosioides induce hypotensive effect that may be partially associated with its cardiac effects. These results may partly explain the traditional use of leaves of C. ambrosioides L. for the treatment of disorders such as hypertension.
Acknowledgments
We express our thanks to Mrs. Mostafa Badraoui and Karim Ramdaoui from our laboratory for the reliable care of animals breeding. This work was supported by grants from CNRST, Morocco [Project URAC-40] and from Belgium [Program 3, CUD Project].
Conflict of interest statement
Authors’ conflict of interest disclosure: The authors stated that there are no conflicts of interest regarding the publication of this article. Research funding played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the report for publication.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
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©2014 by Walter de Gruyter Berlin / Boston
Artikel in diesem Heft
- Frontmatter
- Preclinical Studies
- Hypotensive property of Chenopodium ambrosioides in anesthetized normotensive rats
- Rutin rich Emblica officinalis Geart. fruit extract ameliorates inflammation in the pancreas of rats subjected to alcohol and cerulein administration
- The effect of whole-body, repetitive, inhomogeneous static magnetic field-exposure on the symptoms of experimental autoimmune encephalomyelitis in mice
- Protective effects of aqueous and ethanol extracts of rosemary on H2O2-induced oxidative DNA damage in human lymphocytes by comet assay
- Oxidative hepatotoxicity effects of monocrotaline and its amelioration by lipoic acid, S-adenosyl methionine and vitamin E
- Saffron in metabolic syndrome: its effects on antibody titers to heat-shock proteins 27, 60, 65 and 70
- Clinical Studies
- Rapid effects of Kikyo-to on sore throat pain associated with acute upper respiratory tract infection
Artikel in diesem Heft
- Frontmatter
- Preclinical Studies
- Hypotensive property of Chenopodium ambrosioides in anesthetized normotensive rats
- Rutin rich Emblica officinalis Geart. fruit extract ameliorates inflammation in the pancreas of rats subjected to alcohol and cerulein administration
- The effect of whole-body, repetitive, inhomogeneous static magnetic field-exposure on the symptoms of experimental autoimmune encephalomyelitis in mice
- Protective effects of aqueous and ethanol extracts of rosemary on H2O2-induced oxidative DNA damage in human lymphocytes by comet assay
- Oxidative hepatotoxicity effects of monocrotaline and its amelioration by lipoic acid, S-adenosyl methionine and vitamin E
- Saffron in metabolic syndrome: its effects on antibody titers to heat-shock proteins 27, 60, 65 and 70
- Clinical Studies
- Rapid effects of Kikyo-to on sore throat pain associated with acute upper respiratory tract infection
