Brown adipose tissue, thermogenesis, angiogenesis: pathophysiological aspects

References

1. World Health Organization. Obesity and overweight fact sheet N°311. 2013 (http://www.who.int/mediacentre/factsheets/fs311/en/, accessed April 23, 2014).Suche in Google Scholar

2. Kajimura S, Seale P, Spiegelman BM. Transcriptional control of brown fat development. Cell Metab 2010;11:257–62.10.1016/j.cmet.2010.03.005Suche in Google Scholar PubMed PubMed Central

3. Ricquier D. Uncoupling protein 1 of brown adipocytes, the only uncoupler: a historical perspective. Front Endocrinol (Lausanne) 2011;2:85.10.3389/fendo.2011.00085Suche in Google Scholar PubMed PubMed Central

4. Park A, Kim WK, Bae KH. Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells. World J Stem Cells 2014;6:33–42.10.4252/wjsc.v6.i1.33Suche in Google Scholar PubMed PubMed Central

5. Umekawa T, Yoshida T, Sakane N, Saito M, Kumamoto K, Kondo M. Anti-obesity and anti-diabetic effects of CL316,243, a highly specific beta 3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats: induction of uncoupling protein and activation of glucose transporter 4 in white fat. Eur J Endocrinol 1997;136:429–37.10.1530/eje.0.1360429Suche in Google Scholar PubMed

6. Petrovic N, Walden TB, Shabalina IG, Timmons JA, Cannon B, Nedergaard J. Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J Biol Chem 2010;285:7153–64.10.1074/jbc.M109.053942Suche in Google Scholar PubMed PubMed Central

7. Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scime A, Devarakonda S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM. PRDM16 controls a brown fat/skeletal muscle switch. Nature 2008;454:961–7.10.1038/nature07182Suche in Google Scholar PubMed PubMed Central

8. Cousin B, Cinti S, Morroni M, Raimbault S, Ricquier D, Penicaud L, Casteilla L. Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J Cell Sci 1992;103:931–42.10.1242/jcs.103.4.931Suche in Google Scholar PubMed

9. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JM, Kemerink GJ, Bouvy ND, Schrauwen P, Teule GJ. Cold-activated brown adipose tissue in healthy men. N Engl J Med 2009;360:1500–8.10.1056/NEJMoa0808718Suche in Google Scholar PubMed

10. Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerback S, Nuutila P. Functional brown adipose tissue in healthy adults. N Engl J Med 2009;360:1518–25.10.1056/NEJMoa0808949Suche in Google Scholar PubMed

11. Wu J, Bostrom P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerback S, Schrauwen P. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012;150:366–76.10.1016/j.cell.2012.05.016Suche in Google Scholar PubMed PubMed Central

12. Cypess AM, White AP, Vernochet C, Schulz TJ, Xue R, Sass CA, Huang TL, Roberts-Toler C, Weiner LS, Sze C, Chacko AT, Deschamps LN, Herder LM, Truchan N, Glasgow AL, Holman AR, Gavrila A, Hasselgren PO, Mori MA, Molla M, Tseng YH. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med 2013;19:635–9.10.1038/nm.3112Suche in Google Scholar

13. Jespersen NZ, Larsen TJ, Peijs L, Daugaard S, Homoe P, Loft A, de Jong J, Mathur N, Cannon B, Nedergaard J, Pedersen BK, Moller K, Scheele C. A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. Cell Metab 2013;17:798–805.10.1016/j.cmet.2013.04.011Suche in Google Scholar

14. Lidell ME, Betz MJ, Dahlqvist Leinhard O, Heglind M, Elander L, Slawik M, Mussack T, Nilsson D, Romu T, Nuutila P, Virtanen KA, Beuschlein F, Persson A, Borga M, Enerback S. Evidence for two types of brown adipose tissue in humans. Nat Med 2013;19:631–4.10.1038/nm.3017Suche in Google Scholar

15. Kozak LP, Britton JH, Kozak UC, Wells JM. The mitochondrial uncoupling protein gene. Correlation of exon structure to transmembrane domains. J Biol Chem 1988;263:12274–7.10.1016/S0021-9258(18)37751-2Suche in Google Scholar

16. Nicholls DG, Bernson VS, Heaton GM. The identification of the component in the inner membrane of brown adipose tissue mitochondria responsible for regulating energy dissipation. Experientia Suppl 1978;32:89–93.10.1007/978-3-0348-5559-4_9Suche in Google Scholar PubMed

17. Cannon B, Jacobsson A, Rehnmark S, Nedergaard J. Signal transduction in brown adipose tissue recruitment: noradrenaline and beyond. Int J Obes Relat Metab Disord 1996;20 Suppl 3:S36–42.Suche in Google Scholar

18. Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 2004;84:277–359.10.1152/physrev.00015.2003Suche in Google Scholar PubMed

19. Cannon B, Nedergaard J. Yes, even human brown fat is on fire! J Clin Invest 2012;122:486–9.10.1172/JCI60941Suche in Google Scholar PubMed PubMed Central

20. Nubel T, Ricquier D. Respiration under control of uncoupling proteins: clinical perspective. Horm Res 2006;65:300–10.10.1159/000092847Suche in Google Scholar PubMed

21. Ricquier D. Respiration uncoupling and metabolism in the control of energy expenditure. Proc Nutr Soc 2005;64:47–52.10.1079/PNS2004408Suche in Google Scholar PubMed

22. Rousset S, Alves-Guerra MC, Mozo J, Miroux B, Cassard-Doulcier AM, Bouillaud F, Ricquier D. The biology of mitochondrial uncoupling proteins. Diabetes 2004;53 Suppl 1:S130–5.10.2337/diabetes.53.2007.S130Suche in Google Scholar PubMed

23. Tupone D, Madden CJ, Morrison SF. Autonomic regulation of brown adipose tissue thermogenesis in health and disease: potential clinical applications for altering BAT thermogenesis. Front Nurosci 2014;8:14.10.3389/fnins.2014.00014Suche in Google Scholar PubMed PubMed Central

24. Enerback S. Human brown adipose tissue. Cell Metab 2010;11:248–52.10.1016/j.cmet.2010.03.008Suche in Google Scholar PubMed

25. Xue Y, Petrovic N, Cao R, Larsson O, Lim S, Chen S, Feldmann HM, Liang Z, Zhu Z, Nedergaard J, Cannon B, Cao Y. Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. Cell Metab 2009;9:99–109.10.1016/j.cmet.2008.11.009Suche in Google Scholar PubMed

26. Cao Y. Angiogenesis modulates adipogenesis and obesity. J Clin Invest 2007;117:2362–8.10.1172/JCI32239Suche in Google Scholar PubMed PubMed Central

27. Bukowiecki L, Lupien J, Follea N, Paradis A, Richard D, LeBlanc J. Mechanism of enhanced lipolysis in adipose tissue of exercise-trained rats. Am J Physiol 1980;239:E422–9.10.1152/ajpendo.1980.239.6.E422Suche in Google Scholar PubMed

28. Lim S, Honek J, Xue Y, Seki T, Cao Z, Andersson P, Yang X, Hosaka K, Cao Y. Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice. Nat Protoc 2012;7: 606–15.10.1038/nprot.2012.013Suche in Google Scholar PubMed

29. Elias I, Franckhauser S, Ferre T, Vila L, Tafuro S, Munoz S, Yang X, Hosaka K, Cao Y. Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance. Diabetes 2012;61:1801–13.10.2337/db11-0832Suche in Google Scholar PubMed PubMed Central

30. Ichimiya H, Arakawa S, Sato T, Shimada T, Chiba M, Soma Y, Mizoguchi M, Tomonari K, Iwasaka H, Hatano Y, Okamoto O, Fujiwara S. Involvement of brown adipose tissue in subcutaneous fat necrosis of the newborn. Dermatology 2011;223: 207–10.10.1159/000331810Suche in Google Scholar PubMed

31. Vijgen GH, Bouvy ND, Teule GJ, Brans B, Hoeks J, Schrauwen P, van Marken Lichtenbelt WD. Increase in brown adipose tissue activity after weight loss in morbidly obese subjects. J Clin Endocrin Metab 2012;97:E1229–33.10.1210/jc.2012-1289Suche in Google Scholar PubMed

32. Virtanen KA, van Marken Lichtenbelt WD, Nuutila P. Brown adipose tissue functions in humans. Biochim Biophys Acta 2013;1831:1004–8.10.1016/j.bbalip.2012.12.011Suche in Google Scholar PubMed

33. Bredella MA, Gill CM, Rosen CJ, Klibanski A, Torriani M. Positive effects of brown adipose tissue on femoral bone structure. Bone 2014;58:55–8.10.1016/j.bone.2013.10.007Suche in Google Scholar PubMed PubMed Central

34. Cypess AM, Chen YC, Sze C, Wang K, English J, Chan O, Holman AR, Tal I, Palmer MR, Kolodny GM, Kahn CR. Cold but not sympathomimetics activates human brown adipose tissue in vivo. Proc Natl Acad Sci USA 2012;109:10001–5.10.1073/pnas.1207911109Suche in Google Scholar PubMed PubMed Central

35. van der Lans AA, Hoeks J, Brans B, Vijgen GH, Visser MG, Vosselman MJ, Hansen J, Jorgensen JA, Wu J, Mottaghy FM, Schrauwen P, van Marken Lichtenbelt WD. Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J Clin Invest 2013;123:3395–403.10.1172/JCI68993Suche in Google Scholar PubMed PubMed Central

36. Yoneshiro T, Aita S, Matsushita M, Kayahara T, Kameya T, Kawai Y, Iwanaga T, Saito M. Recruited brown adipose tissue as an antiobesity agent in humans. J Clin Invest 2013;123:3404–8.10.1172/JCI67803Suche in Google Scholar PubMed PubMed Central

37. Dong M, Yang X, Lim S, Cao Z, Honek J, Lu H, Zhang C, Seki T, Hosaka K, Wahlberg E, Yang J, Zhang L, Lanne T, Sun B, Li X, Liu Y, Zhang Y, Cao Y. Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent lipolysis. Cell Metab 2013;18:118–29.10.1016/j.cmet.2013.06.003Suche in Google Scholar PubMed PubMed Central

38. Brent GA. The molecular basis of thyroid hormone action. N Engl J Med 1994;331:847–53.10.1056/NEJM199409293311306Suche in Google Scholar PubMed

39. Lee JY, Takahashi N, Yasubuchi M, Kim YI, Hashizaki H, Kim MJ, Sakamoto T, Goto T, Kawada T. Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes. Am J Physiol Cell Physiol 2012;302:C463–72.10.1152/ajpcell.00010.2011Suche in Google Scholar PubMed

40. Klieverik LP, Coomans CP, Endert E, Sauerwein HP, Havekes LM, Voshol PJ, Rensen PC, Romijn JA, Kalsbeek A, Fliers E. Thyroid hormone effects on whole-body energy homeostasis and tissue-specific fatty acid uptake in vivo. Endocrinology 2009;150:5639–48.10.1210/en.2009-0297Suche in Google Scholar PubMed

41. Ribeiro MO, Bianco SD, Kaneshige M, Schultz JJ, Cheng SY, Bianco AC, Brent GA. Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis. Endocrinology 2010;151:432–40.10.1210/en.2009-0667Suche in Google Scholar PubMed PubMed Central

42. Dulloo AG. Translational issues in targeting brown adipose tissue thermogenesis for human obesity management. Ann N Y Acad Sci 2013;1302:1–10.10.1111/nyas.12304Suche in Google Scholar PubMed PubMed Central

43. Harms M, Seale P. Brown and beige fat: development, function and therapeutic potential. Nat Med 2013;19:1252–63.10.1038/nm.3361Suche in Google Scholar PubMed

44. Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Bostrom EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Hojlund K, Gygi SP, Spiegelman BM. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012;481:463–8.10.1038/nature10777Suche in Google Scholar PubMed PubMed Central

45. Arch JR. The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from beta3-adrenoceptor agonists. Naunyn Schmiedebergs Arch Pharmacol 2008;378:225–40.10.1007/s00210-008-0271-1Suche in Google Scholar PubMed

46. Larsen TM, Toubro S, van Baak MA, Gottesdiener KM, Larson P, Saris WH, Astrup A. Effect of a 28-d treatment with L-796568, a novel beta(3)-adrenergic receptor agonist, on energy expenditure and body composition in obese men. Am J Clin Nutr 2002;76:780–8.10.1093/ajcn/76.4.780Suche in Google Scholar PubMed

47. Buemann B, Toubro S, Astrup A. Effects of the two beta3-agonists, ZD7114 and ZD2079 on 24 hour energy expenditure and respiratory quotient in obese subjects. Int J Obes Relat Disord 2000;24:1553–60.10.1038/sj.ijo.0801452Suche in Google Scholar PubMed

48. Dulloo AG. The search for compounds that stimulate thermogenesis in obesity management: from pharmaceuticals to functional food ingredients. Obes Rev 2011;12:866–83.10.1111/j.1467-789X.2011.00909.xSuche in Google Scholar PubMed

49. Rothwell NJ, Stock MJ. A role for brown adipose tissue in diet-induced thermogenesis. Nature 1979;281:31–5.10.1038/281031a0Suche in Google Scholar PubMed

50. Yoneshiro T, Aita S, Kawai Y, Iwanaga T, Saito M. Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am J Clin Nutr 2012;95:845–50.10.3945/ajcn.111.018606Suche in Google Scholar PubMed

51. Saito M, Yoneshiro T. Capsinoids and related food ingredients activating brown fat thermogenesis and reducing body fat in humans. Curr Opin Lipidol 2013;24:71–7.10.1097/MOL.0b013e32835a4f40Suche in Google Scholar PubMed

52. Sugita J, Yoneshiro T, Hatano T, Aita S, Ikemoto T, Uchiwa H, Iwanaga T, Kameya T, Kawai Y, Saito M. Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men. Br J Nutr 2013;110:733–8.10.1017/S0007114512005715Suche in Google Scholar PubMed

53. Anunciado-Koza R, Ukropec J, Koza RA, Kozak LP. Inactivation of UCP1 and the glycerol phosphate cycle synergistically increases energy expenditure to resist diet-induced obesity. J Biol Chem 2008;283:27688–97.10.1074/jbc.M804268200Suche in Google Scholar

54. Kozak LP. Brown fat and the myth of diet-induced thermogenesis. Cell Metab 2010;11:263–7.10.1016/j.cmet.2010.03.009Suche in Google Scholar

55. Golozoubova V, Cannon B, Nedergaard J. UCP1 is essential for adaptive adrenergic nonshivering thermogenesis. Am J Physiol Endocrinol Metab 2006;291:E350–7.10.1152/ajpendo.00387.2005Suche in Google Scholar

56. Golozoubova V, Hohtola E, Matthias A, Jacobsson A, Cannon B, Nedergaard J. Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold. FASEB J 2001;15:2048–50.10.1096/fj.00-0536fjeSuche in Google Scholar

57. Tonello C, Giordano A, Cozzi V, Cinti S, Stock MJ, Carruba MO, Nisoli E. Role of sympathetic activity in controlling the expression of vascular endothelial growth factor in brown fat cells of lean and genetically obese rats. FEBS Lett 1999;442:167–72.10.1016/S0014-5793(98)01627-5Suche in Google Scholar

58. Cao Y. Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases. Nat Rev Drug Disc 2010;9:107–15.10.1038/nrd3055Suche in Google Scholar PubMed