First trimester pregnancy-associated plasma protein A and human chorionic gonadotropin-beta in early and late pre-eclampsia
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Azra Karahasanovic
und
Lisbeth Nilas
Abstract
Background: The aim of this study was to compare pregnancy-associated plasma protein A (PAPP-A) and the β-subunit of human chorionic gonadotropin (hCGβ) measured in maternal plasma at the first trimester screening, in women who later developed early or late pre-eclampsia (PE) to women with normal pregnancies.
Methods: In the study were included 161 cases with PE and 88 controls with uncomplicated pregnancies. Plasma PAPP-A and hCGβ were measured between gestational age (GA) 8+2 and 14+0, and cases with early and late onset PE were compared with controls.
Results: Median of hCGβ (MoM) was lower in women with early (p<0.05) and late PE (p<0.05) compared to healthy pregnant women. Median (range) of hCGβ (MoM) for women with early onset PE, late onset PE, and women with healthy pregnancies, were 0.75 (0.30–1.21), 0.93 (0.26–3.18), and 0.97 (0.33–4.12), respectively. No significant difference in the median of PAPP-A (MoM) was found between the groups.
Conclusions: hCGβ was significantly lower in pregnancies that subsequently developed PE and might be of use in the effort of trying to find ways to predict PE. No significant difference was found for PAPP-A in our study.
Conflict of interest statement
Authors’ conflict of interest disclosure: The authors stated that there are no conflicts of interest regarding the publication of this article.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
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Artikel in diesem Heft
- Masthead
- Masthead
- Editorials
- Inflammatory bowel diseases: where we are and where we should go
- Thrombophilia testing. Useful or hype?
- Reviews
- Inflammatory bowel diseases: from pathogenesis to laboratory testing
- Crohn’s disease specific pancreatic antibodies: clinical and pathophysiological challenges
- Point/Counterpoint
- The utility of thrombophilia testing
- The futility of thrombophilia testing
- Genetics and Molecular Diagnostics
- Identification of an 18 bp deletion in the TWIST1 gene by CO-amplification at lower denaturation temperature-PCR (COLD-PCR) for non-invasive prenatal diagnosis of craniosynostosis: first case report
- General Clinical Chemistry and Laboratory Medicine
- Agreement of seven 25-hydroxy vitamin D3 immunoassays and three high performance liquid chromatography methods with liquid chromatography tandem mass spectrometry
- First trimester pregnancy-associated plasma protein A and human chorionic gonadotropin-beta in early and late pre-eclampsia
- S100B blood level measurement to exclude cerebral lesions after minor head injury: the multicenter STIC-S100 French study
- NGAL, L-FABP, and KIM-1 in comparison to established markers of renal dysfunction
- Value-added reporting of antinuclear antibody testing by automated indirect immunofluorescence analysis
- Cardiovascular Diseases
- A fit-for-purpose approach to analytical sensitivity applied to a cardiac troponin assay: time to escape the ‘highly-sensitive’ trap
- Diabetes
- A simple and precise method for direct measurement of fractional esterification rate of high density lipoprotein cholesterol by high performance liquid chromatography
- Infectious Diseases
- Detection of unamplified HCV RNA in serum using a novel two metallic nanoparticle platform
- Increased plasma arginase activity in human sepsis: association with increased circulating neutrophils
- Corrigendum
- The relationship between estimated average glucose and fasting plasma glucose
- Letter to the Editors
- The obsessive-compulsory clinical pathologist
- Prism effect of specimen receiving – generation of fundamentals for the smooth progress of analytical processing
- Preanalytical errors: the professionals’ perspective
- Corrected reports in laboratory medicine in a Chinese university hospital for 3 years
- Comparison of an enzymatic assay with liquid chromatography-pulsed amperometric detection for the determination of lactulose and mannitol in urine of healthy subjects and patients with active celiac disease
- Effect of freezing-thawing process on neuron specific enolase concentration in severe traumatic brain injury sera samples
- Undetected creatinine levels
- The effect of centrifugation on three urine protein assays: benzethonium chloride, benzalkonium chloride and pyrogallol red
