Startseite Medizin Suppression of IL-2 and IFN-γ production in women with spontaneous preterm labor
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Suppression of IL-2 and IFN-γ production in women with spontaneous preterm labor

  • Harald Renz , Cathrin Wilke , Ismail Tekesin , Lars Hellmeyer , Udo Herz und Stephan Schmidt
Veröffentlicht/Copyright: 11. Januar 2006

Abstract

Aims: To determine the TH-1/TH-2 cytokine pattern in peripheral blood leukocytes (PBL) in late second- and third trimester in normal pregnancies, in comparison to patients with spontaneous preterm delivery (PTD; <37 completed weeks' gestation).

Methods: A cross-sectional retrospective study was performed in a tertiary care obstetric unit with healthy non-pregnant women (n=7); healthy pregnant women (n=25); patients (n=25) with preterm labor (defined as uterine contractions or changes in cervical length). The phenotypic analysis of TH-1/TH-2 immune deviation was examined in PBL.

Results: 26% PTD (n=13) were recorded. Patients delivering at term (n=37, 74%) were characterized by an upregulation of IL-2, IFN-γ and IL-4 production during weeks 20–25, followed by a strong suppression in cytokine production, except for TGF-β. Towards the end of pregnancy cytokine levels returned to normal as observed in non-pregnant women. In contrast, PTD showed an inverse pattern for IL-2 and IFN-γ with marked suppression in IL-2 and IFN-γ production between weeks 20–25, followed by a strong stimulation of these cytokines. No differences were observed in IL-4 and TGF-β production.

Conclusion: An inverse pattern in IL-2 and IFN-γ production in PBLs between weeks 20–30 is seen in PTD as compared to patients delivering at term.

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Corresponding author: Director: Prof. Dr. Harald Renz 35033 Marburg Baldingerstr Germany Tel.: (+49) 6421 28-66234/5 Fax: (+49) 6421 28-65594

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Published Online: 2006-01-11
Published in Print: 2006-02-01

©2006 by Walter de Gruyter Berlin New York

Heruntergeladen am 31.12.2025 von https://www.degruyterbrill.com/document/doi/10.1515/JPM.2006.003/html
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