Cerebral palsy and fetal inflammatory response syndrome: a review
-
Asher Bashiri
, Eliezer Burstein und Moshe Mazor
Abstract
Cerebral palsy (CP) is the most common cause of severe physical disability in childhood. The precise etiological factor for the development of the majority of cases of CP has not been identified, however, prematurity is considered to be the leading identifiable risk factor.
During the last decade, intrauterine infection/inflamation has been identified as the most common cause of preterm delivery and neonatal complications. When microorganisms or their products gain access to the fetus they stimulate the production of cytokines and a systemic response termed FIRS (Fetal Inflammatory Response Syndrome). Subsequently, FIRS was implicated as a cause of fetal or neonatal injury that leads to CP and chronic lung disease.
Several authors found an increase in the risk for CP in infants born to mothers with clinical chorioamnionitis, especially in preterm neonates. A relationship between CP and intra-amniotic inflammation was demonstrated, intrauterine infection may lead to activation of the cytokine network which in turn can cause white matter brain damage and preterm delivery, as well as the future development of CP. This white matter insult is identified clinically as periventricular leucomalacia (PVL) which is associated with the subsequent development of impaired neurological outcomes of variable severity including CP.
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©2006 by Walter de Gruyter Berlin New York
Artikel in diesem Heft
- WAPM-Newsletter No 1/2006 7thWORLD CONGRESS OF PERINATAL MEDICINE in Zagreb, September 21–24, 2005
- Cerebral palsy and fetal inflammatory response syndrome: a review
- A sonographic short cervix as the only clinical manifestation of intra-amniotic infection
- Suppression of IL-2 and IFN-γ production in women with spontaneous preterm labor
- Does practice make perfect? An age-matched study on grand multiparity in Flanders, Belgium
- Efficacy of a strategy to prevent neonatal early-onset group B streptococcal (GBS) sepsis
- Four-dimensional ultrasonography of the fetal heart using a novel Tomographic Ultrasound Imaging display
- Normal standards for fetal neurobehavioral developments – longitudinal quantification by four-dimensional sonography
- Selective surfactant prophylaxis in preterm infants born at ≤31 weeks' gestation using the stable microbubble test in gastric aspirates
- In-line filters in central venous catheters in a neonatal intensive care unit
- Integrating the role of infection in prediction and prevention of preterm delivery
- Studies on the prevalence of human papillomavirus in pregnant women in Japan
- Unilateral pulmonary agenesis
- Posterior reversible leucoencephalopathy syndrome: a rare complication of preeclampsia
- Isolated spontaneous fetal heart rate decelerations: prognostic significance
- Combination of vasa praevia, true umbilical cord knot and a subserosal hemorrhage
- Neonatal pneumopericardium
- Congress Calendar
- Roster of Perinatal Societies
Artikel in diesem Heft
- WAPM-Newsletter No 1/2006 7thWORLD CONGRESS OF PERINATAL MEDICINE in Zagreb, September 21–24, 2005
- Cerebral palsy and fetal inflammatory response syndrome: a review
- A sonographic short cervix as the only clinical manifestation of intra-amniotic infection
- Suppression of IL-2 and IFN-γ production in women with spontaneous preterm labor
- Does practice make perfect? An age-matched study on grand multiparity in Flanders, Belgium
- Efficacy of a strategy to prevent neonatal early-onset group B streptococcal (GBS) sepsis
- Four-dimensional ultrasonography of the fetal heart using a novel Tomographic Ultrasound Imaging display
- Normal standards for fetal neurobehavioral developments – longitudinal quantification by four-dimensional sonography
- Selective surfactant prophylaxis in preterm infants born at ≤31 weeks' gestation using the stable microbubble test in gastric aspirates
- In-line filters in central venous catheters in a neonatal intensive care unit
- Integrating the role of infection in prediction and prevention of preterm delivery
- Studies on the prevalence of human papillomavirus in pregnant women in Japan
- Unilateral pulmonary agenesis
- Posterior reversible leucoencephalopathy syndrome: a rare complication of preeclampsia
- Isolated spontaneous fetal heart rate decelerations: prognostic significance
- Combination of vasa praevia, true umbilical cord knot and a subserosal hemorrhage
- Neonatal pneumopericardium
- Congress Calendar
- Roster of Perinatal Societies