Startseite Medizin Cerebral palsy and fetal inflammatory response syndrome: a review
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Cerebral palsy and fetal inflammatory response syndrome: a review

  • Asher Bashiri , Eliezer Burstein und Moshe Mazor
Veröffentlicht/Copyright: 11. Januar 2006

Abstract

Cerebral palsy (CP) is the most common cause of severe physical disability in childhood. The precise etiological factor for the development of the majority of cases of CP has not been identified, however, prematurity is considered to be the leading identifiable risk factor.

During the last decade, intrauterine infection/inflamation has been identified as the most common cause of preterm delivery and neonatal complications. When microorganisms or their products gain access to the fetus they stimulate the production of cytokines and a systemic response termed FIRS (Fetal Inflammatory Response Syndrome). Subsequently, FIRS was implicated as a cause of fetal or neonatal injury that leads to CP and chronic lung disease.

Several authors found an increase in the risk for CP in infants born to mothers with clinical chorioamnionitis, especially in preterm neonates. A relationship between CP and intra-amniotic inflammation was demonstrated, intrauterine infection may lead to activation of the cytokine network which in turn can cause white matter brain damage and preterm delivery, as well as the future development of CP. This white matter insult is identified clinically as periventricular leucomalacia (PVL) which is associated with the subsequent development of impaired neurological outcomes of variable severity including CP.

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Corresponding author: Asher Bashiri, MD Department of Obst/Gynecol Soroka University Medical Center PO Box, 151 Beer-Sheva Israel Tel.: +972-8-6403551 Fax: +972-8-6403294

References

1 Arias F, P Tomich: Etiology and outcome of low birth weight and preterm infants. Obstet Gynecol60 (1982) 277Suche in Google Scholar

2 Back SA, SA Rivkees: Emerging concepts in periventricular white matter injury. Semin Perinatol28 (2004) 405Suche in Google Scholar

3 Bale JF Jr, JR Murph: Congenital infections and the nervous system. Pediatr Clin North Am39 (1992) 669Suche in Google Scholar

4 Bashiri A, S Horowitz, M Huleihel, R Hackmon, D Dukler, M Mazor: Elevated concentrations of interleukin-6 in intra-amniotic infection with Ureaplasma urealyticum in asymptomatic women during genetic amniocentesis. Acta Obstet Gynecol Scand78 (1999) 379Suche in Google Scholar

5 Benirschke K: Routes and types of infection in the fetus and the newborn. Am J Dis Child28 (1965) 71410.1001/archpedi.1960.02070030716003Suche in Google Scholar

6 Benirschke K, SH Clifford: Intrauterine bacterial infection of the newborn infant: frozen sections of the cord as an aid to early detection. J Pediatr54 (1959) 11Suche in Google Scholar

7 Berry SM, R Gomez, N Athayde, F Ghezzi, M Mazor, BH Yoon, SS Edwin, R Romero: The role of granulocyte colony stimulating factor in the neutrophilia observed in the fetal inflammatory response syndrome. Am J Obstet Gynecol178 (1998) S202Suche in Google Scholar

8 Blackwell S, R Romero, T Chaiworapongsa, YM Kim, E Bujold, J Espinoza, N Camacho, S Hassan, BH Yoon, JS Refuerzo: Maternal and fetal inflammatory responses in unexplained fetal death. J Matern Fetal Neonatal Med14 (2003) 151Suche in Google Scholar

9 Blanc W: Infection amniotique et neonatal. Gynaecologia136 (1956) 10110.1159/000308314Suche in Google Scholar

10 Blanc W: Pathways of fetal and early neonatal infection: Viral placentitis, bacterial and fungal chorioamnionitis. J Pediatr59 (1964) 47310.1016/S0022-3476(61)80232-1Suche in Google Scholar

11 Blickstein I: Cerebral palsy in multifoetal pregnancies. Dev Med Child Neurol44 (2002) 35210.1017/S0012162201002195Suche in Google Scholar PubMed

12 Brown AS, ES Susser: In utero infection and adult schizophrenia. Ment Retard Dev Disabil Res Rev8 (2002) 51Suche in Google Scholar

13 Cassell GH, RO Davis, KB Waites, MB Brown, PA Marriott, S Stagno, JK Davis: Isolation of Mycoplasma hominis and Ureaplasma urealyticum from amniotic fluid at 16–20 weeks of gestation: potential effect on outcome of pregnancy. Sex Transm Dis10 (1983) 294Suche in Google Scholar

14 Cummins SK, KB Nelson, JK Grether, EM Velie: Cerebral palsy in four northern California counties, births 1983 through 1985. J Pediatr123 (1993) 230Suche in Google Scholar

15 D'Alquen D, BW Kramer, S Seidenspinner, A Marx, D Berg, P Groneck, CP Speer: Activation of umbilical cord endothelial cells and fetal inflammatory response in preterm infants with chorioamnionitis and funisitis. Pediatr Res57 (2005) 263Suche in Google Scholar

16 Dammann O, EN Allred, N Veelken: Increased risk of spastic displegia among very low birth weight children after preterm labor or prelabor rupture of membranes. J Pediatr132 (1998) 531Suche in Google Scholar

17 Duggan PJ, EF Maalouf, TL Watts, MH Sullivan, SJ Counsell, J Allsop, L Al-Nakib, MA Rutherford, M Battin, I Roberts, AD Edwards: Intrauterine T-cell activation and increased proinflammatory cytokine concentrations in preterm infants with cerebral lesions. Lancet358 (2001) 1699Suche in Google Scholar

18 Eastman NJ, M DeLeon: The etiology of cerebral palsy. Am J Obstet Gynecol69 (1955) 950Suche in Google Scholar

19 Fatemi SH, J Earle, R Kanodia, D Kist, ES Emamian, PH Patterson, L Shi, R Sidwell: Prenatal viral infection leads to pyramidal cell atrophy and macrocephaly in adulthood: implications for genesis of autism and schizophrenia. Cell Mol Neurobiol22 (2002) 25Suche in Google Scholar

20 Garnier Y, AB Coumans, A Jensen, TH Hasaart, R Berger: Infection-related perinatal brain injury: the pathogenic role of impaired fetal cardiovascular control. J Soc Gynecol Investig10 (2003) 450Suche in Google Scholar

21 Gibson CS, AH MacLennan, WM Hague, EA Hann, K Priest, A Chan, GA Dekker, South Australian Cerebral Palsy Research Group: Associations between inherited thrombophilias, gestational age, and cerebral palsy. Am J Obstet Gynecol193 (2005) 1437Suche in Google Scholar

22 Gomez R, F Ghezzi, R Romero, H Munoz, JE Tolosa, I Rojas: Premature labor and intra-amniotic infection: clinical aspects and role of the cytokines in diagnosis and pathophysiology. Clin Perinatol22 (1995) 281Suche in Google Scholar

23 Gomez R, R Romero, F Ghezzi, BH Yoon, M Mazor, SM Berry: The fetal inflammatory response syndrome. Am J Obstet Gynecol179 (1998) 194Suche in Google Scholar

24 Goncalves LF, T Chaiworapongsa, R Romero: Intrauterine infection and prematurity. Ment Retard Dev Disabil Res Rev8 (2002) 3Suche in Google Scholar

25 Gray DJ, HB Robinson, J Malone, RB Jr Thomson: Adverse outcome in pregnancy following amniotic fluid isolation of Ureaplasma urealyticum. Prenat Diagn12 (1992) 111Suche in Google Scholar

26 Grether JK, KB Nelson, E Walsh, RE Willoughby, RW Redline: Intrauterine exposure to infection and risk of cerebral palsy in very preterm infants. Arch Pediatr Adolesc Med157 (2003) 26Suche in Google Scholar

27 Horowitz S, M Mazor, R Romero, J Horowitz, M Glezerman: Infection of the amniotic cavity with Ureaplasma urealyticum in the midtrimester of pregnancy. J Reprod Med40 (1995) 375Suche in Google Scholar

28 Hutton JL, PO Pharoah: Effects of cognitive, motor, and sensory disabilities on survival in cerebral palsy. Arch Dis Child86 (2002) 84Suche in Google Scholar

29 Jacobsson B, G Hagberg: Antenatal risk factors for cerebral palsy. Best Pract Res Clin Obstet Gynaecol18 (2004) 425Suche in Google Scholar

30 Jacobsson B, G Hagberg, B Hagberg, L Ladfors, A Niklasson, H Hagberg: Cerebral palsy in preterm infants: a population based analysis of antenatal risk factors. Am J Obstet Gynecol182 (Suppl) (2000) S29Suche in Google Scholar

31 Kallapur SG, I Nitsos, TJ Moss, BW Kramer, JP Newnham, M Ikegami, AH Jobe: Chronic endotoxin exposure does not cause sustained structural abnormalities in the fetal sheep lungs. Am J Physiol Lung Cell Mol Physiol288 (2005) 966Suche in Google Scholar

32 Koman LA, BP Smith, JS Shilt: Cerebral palsy. Lancet363 (2004) 619Suche in Google Scholar

33 Krymko H, A Bashiri, A Smolin, E Sheiner, J Bar-David, I Shoham-Vardi, H Vardi, M Mazor: Risk factors for recurrent preterm delivery. Eur J Obstet Gynecol Reprod Biol113 (2004) 160Suche in Google Scholar

34 Kuban KC, A Leviton: Cerebral palsy. N Engl J Med330 (1994) 188Suche in Google Scholar

35 Leviton A: Preterm birth and cerebral palsy: Is tumor necrosis factor the missing link? Dev Med Child Neurol35 (1993) 55310.1111/j.1469-8749.1993.tb11688.xSuche in Google Scholar PubMed

36 Leviton A, N Paneth: White matter damage in preterm newborns: an epidemiologic perspective. Early Hum Dev53 (1990) 407Suche in Google Scholar

37 MacLennan A: A template for defining a causal relationship between acute intrapartum events and cerebral palsy: international consensus statement. International Cerebral Palsy Task Force. BMJ319 (1999) 105410.1136/bmj.319.7216.1054Suche in Google Scholar PubMed PubMed Central

38 Mallard C, AK Welin, D Peebles, H Hagberg, I Kjellmer: White matter injury following systemic endotoxemia or asphyxia in the fetal sheep. Neurochem Res28 (2003) 215Suche in Google Scholar

39 Markenson GR, RK Martin, M Tillotson-Criss, KS Foley, RS Jr Stewart, M Yancey: The use of the polymerase chain reaction to detect bacteria in amniotic fluid in pregnancies complicated by preterm labor. Am J Obstet Gynecol177 (1997) 1471Suche in Google Scholar

40 Moss TJ, I Nitsos, M Ikegami, AH Jobe, JP Newnham: Experimental intrauterine Ureaplasma infection in sheep. Am J Obstet Gynecol192 (2005) 1179Suche in Google Scholar

41 Nelson KB, JH Ellenberg: Antecedents of cerebral palsy. Univariate analysis of risks. Am J Dis Child139 (1985) 1031Suche in Google Scholar

42 Nelson KB, JH Ellenberg: Antecedents of cerebral palsy. Multivariate analysis of risk. N Engl J Med315 (1986) 81Suche in Google Scholar

43 Nelson KB, JK Lynch: Stroke in newborn infants. The Lancet Neurology3 (2004) 150Suche in Google Scholar

44 O'Callaghan E, P Sham, N Takei, G Glover, RM Murray: Schizophrenia after prenatal exposure to 1957 A2 influenza epidemic. Lancet337 (1991) 1248Suche in Google Scholar

45 Offenbacher S, V Katz, G Fertik, J Collins, D Boyd, G Maynor, R McKaig, J Beck: Periodontal infection as a possible risk factor for preterm low birth weight. J Periodontol67 (1996) 1103Suche in Google Scholar

46 Ohlsson A, M Vearncombe: Congenital and nosocomial sepsis in infants born in a regional perinatal unit: cause, outcome, and white blood cell response. Am J Obstet Gynecol156 (1987) 407Suche in Google Scholar

47 O'Shea TM, KL Klinepeter, RG Dillard: Prenatal events and the risk of cerebral palsy in very low birth weight infants. Am J Epidemiol147 (1998) 362Suche in Google Scholar

48 O'Shea TM, JS Preisser, KL Klinepeter, RG Dillard: Trends in mortality and cerebral palsy in a geographically based cohort of very low birth weight neonates born between 1982 to 1994. Pediatrics101 (1998) 642Suche in Google Scholar

49 Pacora P, T Chaiworapongsa, E Maymon, YM Kim, R Gomez, BH Yoon, F Ghezzi, SM Berry, F Qureshi, SM Jacques, JC Kim, N Kadar, R Romero: Funisitis and chorionic vasculitis: the histological counterpart of the fetal inflammatory response syndrome. J Matern Fetal Neonatal Med11 (2002) 18Suche in Google Scholar

50 Peebles DM, S Miller, JP Newman, R Scott, MA Hanson: The effect of systemic administration of lipopolysaccharide on cerebral haemodynamics and oxygenation in the 0.65 gestation ovine fetus in utero. BJOG110 (2003) 735Suche in Google Scholar

51 Romero R, T Chaiworapongsa, J Espinoza: Micronutrients and intrauterine infection, preterm birth and the Fetal Inflammatory Response Syndrome. J Nutr133 (2003) 5SSuche in Google Scholar

52 Romero R, T Chaiworapongsa, J Espinoza, R Gomez, BH Yoon, S Edwin, M Mazor, E Maymon, S Berry. Fetal plasma MMP-9 concentrations are elevated in preterm premature rupture of the membrance. Am J Obstet Gynecol187 (2002) 1125Suche in Google Scholar

53 Romero R, J Espinoza, LF Goncalves, R Gomez, L Medina, M Silva, T Chaiworapongsa, BH Yoon, F Ghezzi, W Lee, M Treadwell, SM Berry, E Maymon, M Mazor, G DeVore. Fetal cardiac dysfunction in preterm premature rupture of membranes. J Matern Fetal Neonatal Med16 (2004) 146Suche in Google Scholar

54 Romero R, R Gomez, F Ghezzi, BH Yoon, M Mazor, SS Edwin, SM Berry. A fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition. Am J Obstet Gynecol179 (1998) 186Suche in Google Scholar

55 Romero R, E Maymon, P Pacora, R Gomez, M Mazor, BH Yoon, SM Berry. Further observations on the fetal inflammatory response syndrome: a Potential homeostatic role for the soluble receptors of tumor necrosis factor alpha. Am J Obstet Gynecol183 (2000) 1070Suche in Google Scholar

56 Romero R, M Mazor: Infection and preterm labor. Clin Obstet Gynecol31 (1988) 553Suche in Google Scholar

57 Romero R, H Munoz, R Gomez, DM Sherer, F Ghezzi, A Ghidini, O Alfi, G Devore, L Randolph: Two thirds of spontaneous abortion/fetal deaths after genetic amniocentesis are the result of a pre-existing sub-clinical inflammatory process of the amniotic cavity. Am J Obstet Gynecol172 (1995) 261Suche in Google Scholar

58 Romero R, M Sirtori, E Oyarzun, C Avila, M Mazor, R Callahan, V Sabo, AP Athanassiadis, JC Hobbins: Infection and labor. Prevalence, microbiology, and clinical significance of intraamniotic infection in women with preterm labor and intact membranes. Am J Obstet Gynecol161 (1989) 817Suche in Google Scholar

59 Sharief MK, EJ Thompson: In vivo relationship of tumor necrosis factor-alpha to blood-brain barrier damage in patients with active multiple sclerosis. J Neuroimmunol38 (1992) 27Suche in Google Scholar

60 Shim SS, R Romero, JS Hong, CW Park, JK Jun, BI Kim, BH Yoon: Clinical significance of intra-amniotic inflammation in patients with preterm premature rupture of membranes. Am J Obstet Gynecol191 (2004) 1339Suche in Google Scholar

61 Stanley FJ, L Watson: The cerebral palsies in Western Australia: trends, 1968 to 1981. Am J Obstet Gynecol158 (1988) 89Suche in Google Scholar

62 Thompson PJ, A Greenough, HR Gamsu, KH Nicolaides, J Philpott-Howard: Congenital bacterial sepsis in very preterm infants. J Med Microbiol36 (1992) 117Suche in Google Scholar

63 Toti P, C De Felice, M Stumpo, K Schurfeld, L Di Leo, R Vatti, G Bianciardi, G Buonocore, TA Seemayer, P Luzi: Acute thymic involution in fetuses and neonates with chorioamnionitis. Hum Pathol31 (2000) 1121Suche in Google Scholar

64 Yoon BH, JW Chang, R Romero. Isolation of Ureaplasma urealyticum from the amniotic cavity and adverse outcome in preterm labor. Obstet Gynecol92 (1998) 77Suche in Google Scholar

65 Yoon BH, JK Jun, R Romero, KH Park, R Gomez, JH Choi, IO Kim: Amniotic fluid inflammatory cytokines (interleukin-6, interleukin-1beta, and tumor necrosis factor-α), neonatal brain white matter lesions, and cerebral palsy. Am J Obstet Gynecol177 (1997) 19Suche in Google Scholar

66 Yoon BH, SY Oh, R Romero, SS Shim, SY Han, JS Park, JK Jun: An elevated amniotic fluid matrix metalloproteinase-8 level at the time of mid-trimester genetic amniocentesis is a risk factor for spontaneous preterm delivery. Am J Obstet Gynecol185 (2001) 1162Suche in Google Scholar

67 Yoon BH, CW Park, T Chaiworapongsa: Intrauterine infection and the development of cerebral palsy. BJOG110 (Suppl 20) (2003) 12410.1046/j.1471-0528.2003.00063.xSuche in Google Scholar

68 Yoon BH, R Romero, JH Lim, SS Shim, JS Hong, JY Shim, JK Jun: The clinical significance of detecting Ureaplasma urealyticum by the polymerase chain reaction in the amniotic fluid of patients with preterm labor Am J Obstet Gynecol189 (2003) 919Suche in Google Scholar

69 Yoon BH, R Romero, JS Park, JW Chang, YA Kim, JC Kim, KS Kim: Microbial invasion of the amniotic cavity with Ureaplasma urealyticum is associated with a robust host response in fetal, amniotic, and maternal compartments. Am J Obstet Gynecol179 (1998) 1254Suche in Google Scholar

70 Yoon BH, R Romero, JS Park, CJ Kim, SH Kim, JH Choi, TR Han: Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years. Am J Obstet Gynecol182 (2000) 675Suche in Google Scholar

71 Yoon BH, R Romero, JS Park, M Kim, SY Oh, CJ Kim, JK Jun: The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis. Am J Obstet Gynecol183 (2000) 1124Suche in Google Scholar

72 Yoon BH, R Romero, SH Yang, JK Jun, IO Kim, JH Choi, HC Syn: Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia. Am J Obstet Gynecol174 (1996) 1433Suche in Google Scholar

73 Watts DH, MA Krohn, SL Hillier, DA Eschenbach: The association of occult amniotic fluid infection with gestational age and neonatal outcome among women in preterm labor. Obstet Gynecol79 (1992) 351Suche in Google Scholar

74 Wharton KN, H Pinar, BS Stonestreet, R Tucker, KR McLean, M Wallach, BR Vohr: Severe umbilical cord inflammation – a predictor of periventricular leukomalacia in very low birth weight infants. Early Hum Dev77 (2004) 77Suche in Google Scholar

Published Online: 2006-01-11
Published in Print: 2006-02-01

©2006 by Walter de Gruyter Berlin New York

Heruntergeladen am 31.12.2025 von https://www.degruyterbrill.com/document/doi/10.1515/JPM.2006.001/html
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